Biology: Genetics and Cell Biology: cram pack

Formula sheets, the key method steps for every topic and 4 practice problems, with full solutions at the back.

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1Formulas and methods

Genetics

Monohybrid cross (Aa × Aa)
genotypes 1 : 2 : 1, phenotypes 3 : 1
Dihybrid cross
phenotypes 9 : 3 : 3 : 1
Hardy–Weinberg
p + q = 1, p² + 2pq + q² = 1
Independent genes
multiply the probabilities

2Practice problems

1.GeneticsMedium
♂♀YXh​XH​Xh​

haemophilia is X-linked recessive (allele h). A carrier mother, XHXh, has children with an affected father, XhY. The mother's gametes run down the side. Click the cell for a carrier daughter.

♀ XHXh♂ XhY
  1. 1XH × Y
  2. 2XH × Xh
  3. 3Xh × Y
  4. 4Xh × Xh
2.GeneticsHard
♂ AaBb♀ AaBbaBABAbabABabAbaB

Two AaBb parents are crossed. Gene A gives black fur (dominant) or white fur; gene B gives round seeds (dominant) or wrinkled seeds. Click the one cell for an offspring that is homozygous for black fur and shows wrinkled seeds.

AaBb × AaBb
  1. 1AB × aB
  2. 2AB × AB
  3. 3AB × Ab
  4. 4AB × ab
  5. 5ab × aB
  6. 6ab × AB
  7. 7ab × Ab
  8. 8ab × ab
  9. 9Ab × aB
  10. 10Ab × AB
  11. 11Ab × Ab
  12. 12Ab × ab
  13. 13aB × aB
  14. 14aB × AB
  15. 15aB × Ab
  16. 16aB × ab
3.Cell biologyMedium

What role does cholesterol play in animal cell membranes?

  1. AIt forms channels for ions
  2. BIt helps keep membrane fluidity stable across temperatures
  3. CIt makes the membrane completely rigid at every temperature
  4. DIt is the main carrier of glucose
4.Cell biologyHard

A signal molecule that cannot cross the membrane, such as adrenaline, acts by:

  1. ADiffusing into the nucleus and binding DNA to change gene transcription
  2. BBinding a surface receptor that triggers a second-messenger cascade
  3. CBeing converted into ATP
  4. DDissolving the membrane

3Solutions

1.Genetics

Answer: XH × Xh

Punnett square: one parent's gametes run along the top, the other's down the side. Each cell joins the gamete above it with the gamete beside it, and every cell is equally likely. A recessive trait only shows when both alleles are recessive; for an X-linked trait, sons get their only X from the mother.

Fill the square

XHY, XHXh, XhY, XhXh

Find the cell

XH × Xh = XHXh

Answer

Cell XH × Xh → XHXh
2.Genetics

Answer: Ab × Ab

Punnett square: one parent's gametes run along the top, the other's down the side. Each cell joins the gamete above it with the gamete beside it, and every cell is equally likely. A recessive trait only shows when both alleles are recessive; for an X-linked trait, sons get their only X from the mother.

Genotype asked for

AAbb

Gametes

A homozygous genotype needs the same gamete from both parents, so only one cell in the 16 fits.

Ab × Ab = AAbb

Answer

Cell Ab × Ab → AAbb
3.Cell biology

Answer: B · It helps keep membrane fluidity stable across temperatures

Why this is the answer

Cholesterol reduces fluidity at high temperatures and prevents tight packing at low temperatures, buffering membrane fluidity.

Answer

B · It helps keep membrane fluidity stable across temperatures
4.Cell biology

Answer: B · Binding a surface receptor that triggers a second-messenger cascade

Why this is the answer

Hydrophilic signals bind membrane receptors (e.g. G-protein-coupled receptors), activating intracellular messengers; steroid hormones instead cross the membrane.

Answer

B · Binding a surface receptor that triggers a second-messenger cascade

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