Genetics
- Monohybrid cross (Aa × Aa)
- genotypes 1 : 2 : 1, phenotypes 3 : 1
- Dihybrid cross
- phenotypes 9 : 3 : 3 : 1
- Hardy–Weinberg
- p + q = 1, p² + 2pq + q² = 1
- Independent genes
- multiply the probabilities
Formula sheets, the key method steps for every topic and 4 practice problems, with full solutions at the back.
haemophilia is X-linked recessive (allele h). A carrier mother, XHXh, has children with an unaffected father, XHY. The mother's gametes run down the side. Click the cell for an unaffected son.
Two AaBb parents are crossed. Gene A gives yellow seeds (dominant) or green seeds; gene B gives black fur (dominant) or white fur. Click the one cell for an offspring that is homozygous for yellow seeds and shows white fur.
Which cell junction seals neighbouring epithelial cells together and stops fluid leaking between them?
In Tay–Sachs disease, a ganglioside builds up in nerve cells because of a missing enzyme. In which organelle does the build-up occur?
Answer: XH × Y
Punnett square: one parent's gametes run along the top, the other's down the side. Each cell joins the gamete above it with the gamete beside it, and every cell is equally likely. A recessive trait only shows when both alleles are recessive; for an X-linked trait, sons get their only X from the mother.
Answer: Ab × Ab
Punnett square: one parent's gametes run along the top, the other's down the side. Each cell joins the gamete above it with the gamete beside it, and every cell is equally likely. A recessive trait only shows when both alleles are recessive; for an X-linked trait, sons get their only X from the mother.
A homozygous genotype needs the same gamete from both parents, so only one cell in the 16 fits.
Answer: A · Tight junction
Tight junctions join membranes of adjacent cells closely, blocking the paracellular route, for example in the gut lining and the blood–brain barrier.
Answer: B · Lysosome
Tay–Sachs is a lysosomal storage disease. Lack of hexosaminidase A means GM2 ganglioside cannot be broken down and accumulates in neuronal lysosomes.
ExamProblems · examproblems.com/courses/biology