A woman at 41 weeks has a Bishop score of 3 and is booked for induction. What is the most likely first step?
AAn immediate amniotomy at the bedside
BA high-dose oxytocin infusion straight away
CCervical ripening with a prostaglandin
DAn emergency caesarean
3.Dosage calculationsMedium
A vial contains 2 g of powder. The label says: add 9.2 mL of water for injection to give a total volume of 10 mL. The prescription is 160 mg. What volume V of the reconstituted solution do you give?
2 g+ 9.2 mL → 10 mL160 mg
V = mL
4.Dosage calculationsHard
You must prepare 1000 mL of a 0.5% (w/v) solution from a 50% (w/v) stock solution. How much water W must be added to the stock?
C₁ = 50%C₂ = 0.5%V₂ = 1000 mL
W = mL
5.IV infusion ratesMedium
A drip runs at 40 gtt/min through a set of 20 gtt/mL. How many millilitres V does the patient receive in 12 hours?
40 gtt/min20 gtt/mL12 h
V = mL
6.IV infusion ratesHard
1000 mg of a drug is diluted in 250 mL and given by gravity through a set of 60 gtt/mL. The order is 80 mg per hour. Find the drip rate R in drops per minute.
1000 mg/250 mL80 mg/h60 gtt/mL
R = gtt/min
3Solutions
1.Maternity & obstetric nursing
Answer: C · Haemolysis, elevated liver enzymes, low platelets
Why this is the answer
HELLP syndrome is a serious complication of pre-eclampsia. Right upper quadrant or epigastric pain, nausea and malaise are typical, and blood pressure is not always very high.
Answer
C · Haemolysis, elevated liver enzymes, low platelets
2.Maternity & obstetric nursing
Answer: C · Cervical ripening with a prostaglandin
Why this is the answer
A low Bishop score means the cervix is not ready. Cervical ripening with prostaglandins or a balloon catheter is done before oxytocin or amniotomy, which may not be possible with a closed cervix.
Answer
C · Cervical ripening with a prostaglandin
3.Dosage calculations
Answer: V = 0.8 mL
Dose calculation: the amount to give equals what is prescribed divided by what you have, times the quantity it comes in: amount = (desired dose/stock strength) × stock volume. Always keep the units the same (convert g to mg, mg to mcg first) and check that the answer is sensible.
Concentration after mixing
2000 mg/10 mL = 200 mg/mL
Volume
V = 160/200 = 0.8 mL
Answer
V = 0.8 mL
4.Dosage calculations
Answer: W = 990 mL
Solution strengths: a percentage strength is grams per 100 mL, so 1% = 1 g/100 mL = 10 mg/mL. A ratio strength 1:1000 means 1 g in 1000 mL = 1 mg/mL; 1:10 000 is 0.1 mg/mL. For a dilution the amount of drug stays the same: C₁·V₁ = C₂·V₂.
Volume of stock
V₁ = 0.5·1000/50 = 10 mL
Water to add
W = 1000 − 10 = 990 mL
Answer
W = 990 mL
5.IV infusion rates
Answer: V = 1440 mL
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.
Rate in mL/h
40·60/20 = 120 mL/h
Volume
V = 120·12 = 1440 mL
Answer
V = 1440 mL
6.IV infusion rates
Answer: R = 20 gtt/min
Dose-based infusions: concentration = amount of drug in the bag/bag volume. Pump rate (mL/h) = dose per hour/concentration, and dose per hour = mL/h × concentration. Convert per-minute doses to per-hour (× 60) and keep the mass units the same (1 g = 1000 mg, 1 mg = 1000 mcg).