Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient has exercise-induced asthma. Which advice is most appropriate?
AExercise only in cold, dry air to toughen the airways
BAvoid all forms of exercise permanently to prevent attacks
CUse the reliever inhaler shortly before exercise and warm up
DTake a beta-blocker before exercise
2.Med-surg: cardiovascular & respiratoryHard
A 25-year-old non-smoker has wheeze and cough that come and go, worse at night and after exercise. Spirometry improves markedly after a bronchodilator. Which diagnosis is most likely?
AHeart failure
BAsthma
CIdiopathic pulmonary fibrosis
DCOPD
3.Med-surg: neuro, endocrine & renalMedium
A patient taking a GLP-1 receptor agonist has severe, constant upper abdominal pain spreading to the back, with vomiting. What should the nurse suspect?
ANormal nausea from the drug
BA simple urinary tract infection
CAcute pancreatitis
DLow blood glucose
4.Med-surg: neuro, endocrine & renalHard
The night after hip surgery, an 84-year-old becomes suddenly confused and tries to pull out their IV line. What is the most appropriate first step?
ATell the family that this is the start of dementia
BLook for causes such as low oxygen, pain, retention or infection
CAsk for a strong sedative so that the patient can sleep
DApply wrist restraints to protect the IV line
5.Med-surg: GI, perioperative & oncologyMedium
Which wound drain observation should be reported immediately?
AA little dried blood around the drain site
BDrainage slowly falling each day
CA sudden large volume of fresh red blood
DSmall amounts of pink serous fluid
6.Med-surg: GI, perioperative & oncologyHard
A patient taking oral capecitabine reports red, painful, peeling palms and soles. What should the nurse do?
ATell the patient to take a double dose next time
BAdvise hot soaks for the hands and feet
CReassure that it is a sign of an unrelated allergy to washing powder
DReport it; this is hand-foot syndrome and treatment may need changing
7.Clinical nursingMedium
Which side effect is common when a patient starts taking metformin?
ANausea, abdominal discomfort or diarrhoea
BSevere headache
CRapid weight gain
DHypoglycaemia in most patients who take it
8.Clinical nursingHard
Shortly after starting a transfusion, a patient becomes breathless, wheezy and hypotensive with facial swelling. What should the nurse do first?
ASlow the transfusion rate and recheck the observations in an hour
BStop the transfusion, keep IV access and call for urgent help
CGive paracetamol and an antihistamine and continue the transfusion
DFinish the unit quickly so the exposure time is as short as possible
9.Lab values & electrolytesMedium
A patient has IV fluids running into the left forearm. Where should the nurse take a blood sample?
AFrom just above the IV site in the same arm
BFrom any vein, since the fluid does not affect results
CFrom the IV cannula while the fluid is running
DFrom the opposite arm
10.Lab values & electrolytesHard
A patient with alcohol use disorder has a potassium of 3.0 mEq/L despite two days of replacement. The magnesium is 0.9 mEq/L. What is the most appropriate next step?
ADouble the potassium dose and leave the magnesium for later
BReplace the magnesium; low magnesium keeps the kidneys losing potassium
CGive a diuretic to remove the excess magnesium
DStop all electrolyte replacement for 24 hours and recheck
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 134 mmol/L, glucose 27.9 mmol/L and urea 10.4 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 134 mmol/Lglucose 27.9 mmol/Lurea 10.4 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic alkalosis with HCO₃⁻ 38 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 38 mmol/L
PaCO₂ = mmHg
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Interpret this lead II strip with the five steps in order: rate, rhythm, P waves, PR interval, QRS duration. At which step do you find the first abnormal finding? Click it.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1rate
2rhythm
3P waves
4PR interval
5QRS duration
15.Prioritization & delegationMedium
A nurse teaches foot care to a patient with diabetes. Which statement shows a need for further teaching?
A“I will wear shoes that fit well, even at home.”
B“I will soak my feet in hot water every evening.”
C“I will dry well between my toes after washing.”
D“I will check the soles of my feet every day with a mirror.”
16.Prioritization & delegationHard
A patient with Guillain-Barré syndrome has weakness that is spreading up from the legs. Which assessment has the highest priority?
ASkin condition over the heels
BMuscle strength in the feet and ankles at the start of each morning
CThe patient’s mood and coping
DBreathing strength, such as vital capacity and the ability to cough
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Use the reliever inhaler shortly before exercise and warm up
Why this is the answer
A short-acting bronchodilator taken shortly before exercise, a gradual warm-up and covering the mouth in cold air help prevent symptoms. Frequent exercise symptoms may mean asthma is poorly controlled and preventer treatment needs review.
Answer
C · Use the reliever inhaler shortly before exercise and warm up
2.Med-surg: cardiovascular & respiratory
Answer: B · Asthma
Why this is the answer
Asthma typically causes variable symptoms with reversible airflow obstruction. COPD usually affects older people with a smoking history and causes persistent, poorly reversible obstruction. Fibrosis gives a restrictive pattern.
Answer
B · Asthma
3.Med-surg: neuro, endocrine & renal
Answer: C · Acute pancreatitis
Why this is the answer
GLP-1 receptor agonists have been linked to acute pancreatitis. Severe persistent abdominal pain radiating to the back needs urgent assessment, and the drug is stopped if pancreatitis is suspected.
Answer
C · Acute pancreatitis
4.Med-surg: neuro, endocrine & renal
Answer: B · Look for causes such as low oxygen, pain, retention or infection
Why this is the answer
Acute confusion after surgery is often delirium. The nurse first looks for causes: hypoxia, pain, retention, constipation, infection, low glucose, dehydration and drugs. Sedation and restraints can make it worse and are a last resort.
Answer
B · Look for causes such as low oxygen, pain, retention or infection
5.Med-surg: GI, perioperative & oncology
Answer: C · A sudden large volume of fresh red blood
Why this is the answer
A sudden increase in bright red drainage suggests active haemorrhage. The nurse checks vital signs and informs the surgical team urgently. Gradually decreasing serosanguinous drainage is expected.
Answer
C · A sudden large volume of fresh red blood
6.Med-surg: GI, perioperative & oncology
Answer: D · Report it; this is hand-foot syndrome and treatment may need changing
Why this is the answer
Palmar-plantar erythrodysaesthesia (hand-foot syndrome) is common with capecitabine and fluorouracil. It is graded and may need a treatment break or dose reduction; emollients and avoiding heat and friction help.
Answer
D · Report it; this is hand-foot syndrome and treatment may need changing
7.Clinical nursing
Answer: A · Nausea, abdominal discomfort or diarrhoea
Why this is the answer
Gastrointestinal upset is common at the start, so metformin is started at a low dose with food and increased gradually. It rarely causes hypoglycaemia when used alone.
Answer
A · Nausea, abdominal discomfort or diarrhoea
8.Clinical nursing
Answer: B · Stop the transfusion, keep IV access and call for urgent help
Why this is the answer
Severe transfusion reactions, including anaphylaxis, require immediately stopping the transfusion, keeping venous access, following the ABCDE approach and treating anaphylaxis with IM adrenaline.
Answer
B · Stop the transfusion, keep IV access and call for urgent help
9.Lab values & electrolytes
Answer: D · From the opposite arm
Why this is the answer
Blood taken near a running infusion is mixed with the IV fluid, causing false results, such as a high glucose or a low hemoglobin. The sample is taken from the other arm, or according to policy if that is not possible.
Answer
D · From the opposite arm
10.Lab values & electrolytes
Answer: B · Replace the magnesium; low magnesium keeps the kidneys losing potassium
Why this is the answer
Low magnesium makes the kidneys lose potassium, so hypokalemia does not correct until the magnesium is replaced. Both are common in alcohol use disorder.Checked against:Low blood potassium · MedlinePlus (NIH) (2025); Magnesium Blood Test · MedlinePlus (NIH) (2023)
Answer
B · Replace the magnesium; low magnesium keeps the kidneys losing potassium
11.Arterial blood gas interpretation
Answer: Osm = 306 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·134 + 27.9 + 10.4 = 306.3 ≈ 306 mOsm/kg
Answer
Osm = 306 mOsm/kg
12.Arterial blood gas interpretation
Answer: PaCO₂ = 47.6 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·38 + 21 = 47.6 mmHg
Answer
PaCO₂ = 47.6 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
13.ECG rhythm strip interpretation
Answer: QTc = 0.393 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 9 × 0.04 = 0.36 s
RR = 21 × 0.04 = 0.84 s
Bazett’s formula
QTc = 0.36/√0.84 = 0.36/0.9165 = 0.393 s
Answer
QTc = 0.393 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (393 ms)
14.ECG rhythm strip interpretation
Answer: QRS duration
Five steps for every strip: 1. rate (300 or 1500 method, or the 6-second method if irregular); 2. rhythm: are the R–R intervals equal; 3. P waves: present, upright in lead II, one before every QRS and all alike; 4. PR interval: 0.12–0.20 s and constant; 5. QRS duration: below 0.12 s. Only after the five steps name the rhythm. Normal sinus rhythm passes all five: 60–100/min, regular, upright P before every QRS, PR 0.12–0.20 s, QRS below 0.12 s.
Five steps
1. Rate: R–R = 19 small boxes, 1500 ÷ 19 ≈ 79 per minute.
2. Rhythm: regular, every R–R is 0.76 s.
3. P waves: upright, one before every QRS, all alike.
4. PR interval: 0.14 s, constant, within 0.12–0.20 s.
5. QRS: 0.12 s, wide (0.12 s or more).
First abnormal step
QRS duration → sinus rhythm with wide QRS
Answer
QRS duration
15.Prioritization & delegation
Answer: B · “I will soak my feet in hot water every evening.”
Why this is the answer
Neuropathy can stop the patient feeling heat, so hot soaks can cause burns, and long soaking dries the skin. Daily checks, careful drying and well-fitting shoes are correct.
Answer
B · “I will soak my feet in hot water every evening.”
16.Prioritization & delegation
Answer: D · Breathing strength, such as vital capacity and the ability to cough
Why this is the answer
Guillain-Barré syndrome causes ascending weakness that can involve the respiratory muscles. Falling vital capacity or a weak cough can mean the patient needs ventilation, so breathing is monitored closely.
Answer
D · Breathing strength, such as vital capacity and the ability to cough