Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Why is a raised serum lactate concerning in a patient with shock?
AIt suggests tissues are short of oxygen and using anaerobic metabolism
BIt shows only that the patient has eaten a large meal in the past hour
CIt confirms a bacterial infection is present
DIt means the kidneys are working harder than normal to clear fluid
2.Med-surg: cardiovascular & respiratoryHard
One hour after cardiac surgery, a mediastinal chest drain has drained 350 mL of bright red blood and the heart rate is rising. What should the nurse do?
AReport it to the surgical team at once
BClamp the drain to stop further blood loss
CStrip the tubing hard every five minutes
DRecord the volume and continue hourly checks
3.Med-surg: neuro, endocrine & renalMedium
Before IV thrombolysis for stroke, which blood pressure limit is commonly used?
AAbove about 200/120 mmHg
BBelow about 90/60 mmHg
CThere is no blood pressure limit
DBelow about 185/110 mmHg
4.Med-surg: neuro, endocrine & renalHard
Two days after surgery, an 80-year-old woman is quiet, sleepy, slow to answer and eating little. Her daughter says she is "not herself". What should the nurse suspect?
ASimple low mood about being in hospital
BNormal tiredness after an operation
CHypoactive delirium
DThe start of Alzheimer's disease
5.Med-surg: GI, perioperative & oncologyMedium
Why is it important when a patient on opioids becomes more sedated?
ARising sedation usually comes before respiratory depression
BSedation is a harmless and expected effect of all opioids
CSedation means that a higher dose is now needed
DSedation means that the pain is now fully and safely controlled
6.Med-surg: GI, perioperative & oncologyHard
Which safety rule applies to vincristine?
AIt can be given by whichever route the prescriber prefers
BIt is best given as a fast IV push into a small vein
CNever intrathecal; supplied in a minibag for IV use only
DIt is usually given intrathecally with other spinal drugs
7.Clinical nursingMedium
A patient with COPD and known carbon dioxide retention needs a nebulised bronchodilator. How should it usually be given?
ADriven by compressed air, with oxygen given separately if needed
BDriven by high-flow oxygen at 15 L/min for as long as possible
CWithout monitoring oxygen saturation
DOnly with the patient lying flat
8.Clinical nursingHard
Which patient should a ward nurse assess first at the start of a shift?
AA patient with new-onset confusion and a respiratory rate of 28/min
BA patient asking for a laxative
CA patient with chronic back pain scored 4/10
DA patient awaiting discharge with stable observations
9.Lab values & electrolytesMedium
How does normal pregnancy usually affect serum creatinine?
AIt rises with every week
BIt falls, because GFR rises
CIt stays exactly the same
DIt rises, because GFR falls
10.Lab values & electrolytesHard
A patient with alcohol use disorder has a potassium of 3.0 mEq/L despite two days of replacement. The magnesium is 0.9 mEq/L. What is the most appropriate next step?
AStop all electrolyte replacement for 24 hours and recheck
BGive a diuretic to remove the excess magnesium
CDouble the potassium dose and leave the magnesium for later
DReplace the magnesium; low magnesium keeps the kidneys losing potassium
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.43, PaCO₂ 58 mmHg (7.7 kPa) and HCO₃⁻ 37 mmol/L. The primary disorder is metabolic alkalosis. How far is it compensated? Click your answer.
pH 7.43PaCO₂ 58 mmHg (7.7 kPa)HCO₃⁻ 37 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
Practice values: Na⁺ 135, Cl⁻ 88 and HCO₃⁻ 9 mmol/L. Calculate the delta ratio (AG − 12)/(24 − HCO₃⁻), using AG = Na⁺ − (Cl⁻ + HCO₃⁻). Give two decimals.
Na⁺ 135 mmol/LCl⁻ 88 mmol/LHCO₃⁻ 9 mmol/L
delta ratio =
13.ECG rhythm strip interpretationMedium
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1sinus bradycardia
2atrial fibrillation
3first-degree AV block
4junctional rhythm
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1junctional rhythm
2sinus bradycardia
3asystole
4third-degree (complete) AV block
15.Prioritization & delegationMedium
A patient receives hemodialysis this morning. Which type of medication is often held before dialysis, as prescribed?
AAntihypertensive drugs
BInhaled bronchodilators
CTopical skin creams
DEye drops for glaucoma
16.Prioritization & delegationHard
A nurse has a needlestick injury from a used needle. What should the nurse do first?
AScrub the area with bleach
BWash the area with soap and water
CFinish the shift and report it tomorrow
DSqueeze the wound hard and suck it
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: A · It suggests tissues are short of oxygen and using anaerobic metabolism
Why this is the answer
When tissues are poorly perfused, cells switch to anaerobic metabolism and produce lactate. A raised lactate is a marker of tissue hypoperfusion and severity in sepsis and shock. Repeated measurements show whether treatment is working.
Answer
A · It suggests tissues are short of oxygen and using anaerobic metabolism
2.Med-surg: cardiovascular & respiratory
Answer: A · Report it to the surgical team at once
Why this is the answer
Drainage of more than about 100–200 mL/h (or a sudden large volume of fresh blood), especially with tachycardia or hypotension, may indicate surgical bleeding and needs urgent review. Clamping could cause cardiac tamponade. A sudden stop in drainage with falling blood pressure can also signal tamponade.
Answer
A · Report it to the surgical team at once
3.Med-surg: neuro, endocrine & renal
Answer: D · Below about 185/110 mmHg
Why this is the answer
Many guidelines require blood pressure below 185/110 mmHg before thrombolysis and below 180/105 mmHg for 24 hours afterwards, because very high pressure increases the risk of haemorrhagic transformation. Higher readings are lowered carefully first.
Answer
D · Below about 185/110 mmHg
4.Med-surg: neuro, endocrine & renal
Answer: C · Hypoactive delirium
Why this is the answer
Hypoactive delirium presents with drowsiness, withdrawal and slowness rather than agitation, so it is often missed. It has a worse prognosis than the hyperactive form. A family report of a sudden change is important, and a screening tool such as the 4AT or the CAM (Confusion Assessment Method) can be used.
Answer
C · Hypoactive delirium
5.Med-surg: GI, perioperative & oncology
Answer: A · Rising sedation usually comes before respiratory depression
Why this is the answer
Sedation scores often worsen before the respiratory rate falls. Monitoring sedation (for example with a sedation scale) as well as respiratory rate and oxygen saturation helps detect opioid toxicity early. Increasing sedation means the next dose should be held and the patient reviewed.
Answer
A · Rising sedation usually comes before respiratory depression
6.Med-surg: GI, perioperative & oncology
Answer: C · Never intrathecal; supplied in a minibag for IV use only
Why this is the answer
Intrathecal vincristine is almost always fatal. To prevent wrong-route errors, it is diluted in a minibag for IV use, labelled "for intravenous use only, fatal if given by other routes" and kept separate from intrathecal drugs.
Answer
C · Never intrathecal; supplied in a minibag for IV use only
7.Clinical nursing
Answer: A · Driven by compressed air, with oxygen given separately if needed
Why this is the answer
Nebulisers driven by high-flow oxygen can raise PaCO2 in patients at risk. Air-driven nebulisers are used, with supplementary oxygen via nasal cannulae to keep saturation in the target range.
Answer
A · Driven by compressed air, with oxygen given separately if needed
8.Clinical nursing
Answer: A · A patient with new-onset confusion and a respiratory rate of 28/min
Why this is the answer
New confusion with tachypnoea suggests acute deterioration, such as sepsis or hypoxia. Patients with stable chronic problems can wait.
Answer
A · A patient with new-onset confusion and a respiratory rate of 28/min
9.Lab values & electrolytes
Answer: B · It falls, because GFR rises
Why this is the answer
In pregnancy, kidney blood flow and GFR rise by about 50%, so creatinine falls below non-pregnant values. A creatinine that looks "normal" for a non-pregnant adult may indicate reduced kidney function in pregnancy.
Answer
B · It falls, because GFR rises
10.Lab values & electrolytes
Answer: D · Replace the magnesium; low magnesium keeps the kidneys losing potassium
Why this is the answer
Low magnesium makes the kidneys lose potassium, so hypokalemia does not correct until the magnesium is replaced. Both are common in alcohol use disorder.Checked against:Low blood potassium · MedlinePlus (NIH) (2025); Magnesium Blood Test · MedlinePlus (NIH) (2023)
Answer
D · Replace the magnesium; low magnesium keeps the kidneys losing potassium
11.Arterial blood gas interpretation
Answer: fully compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.43: within 7.35–7.45
PaCO₂ 58 mmHg: high (35–45)
HCO₃⁻ 37 mmol/L: high (22–26)
Compensation
Clinically, also check the expected compensation: for a metabolic alkalosis PaCO₂ ≈ 0.7·HCO₃⁻ + 21 = 44.9–48.9 mmHg, so the measured 58 mmHg points to an additional respiratory acidosis (a mixed disorder). The answer above is the ROME exam classification.
fully compensated
Answer
fully compensated
12.Arterial blood gas interpretation
Answer: delta ratio = 1.733
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 135 − (88 + 9) = 38
Delta ratio
(38 − 12)/(24 − 9) = 26/15 = 1.733
Answer
delta ratio = 1.733
Between 1 and 2: a pure high anion gap acidosis.
13.ECG rhythm strip interpretation
Answer: junctional rhythm
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 30 small boxes, 1500 ÷ 30 ≈ 50 per minute.
2. Rhythm: regular, every R–R is 1.20 s.
3. P waves: none visible.
4. PR interval: not measurable.
5. QRS: 0.06 s, narrow (below 0.12 s).
Interpretation
junctional rhythm
Answer
junctional rhythm
14.ECG rhythm strip interpretation
Answer: asystole
Ventricular rhythms: ventricular tachycardia is a run of three or more wide (0.12 s or more) complexes in a row at more than 100/min, usually 150–250/min, regular, without related P waves. Ventricular fibrillation is a chaotic, irregular waveform with no identifiable P waves, QRS complexes or T waves and no countable rate. Asystole is an almost flat line with no ventricular activity; a flat line is always confirmed by checking the patient, the leads and the gain and a second lead. In resuscitation guidelines VF and pulseless VT are the shockable rhythms and asystole is not.
Five steps
1. Rate: no countable ventricular rate.
2. Rhythm: none; an almost flat line.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: no QRS complexes.
Interpretation
asystole
Answer
asystole
A flat line is always checked: look at the patient, the leads and the gain, and view a second lead, because a loose electrode or fine VF can look like asystole.
15.Prioritization & delegation
Answer: A · Antihypertensive drugs
Why this is the answer
Removing fluid during dialysis can cause hypotension, so blood pressure drugs are often held before treatment as prescribed. Some drugs are also removed by dialysis and given afterwards.
Answer
A · Antihypertensive drugs
16.Prioritization & delegation
Answer: B · Wash the area with soap and water
Why this is the answer
The wound is washed with soap and water at once. The nurse then reports the injury immediately so the source patient can be tested and post-exposure treatment considered.