Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Which foot care advice is correct for a patient with peripheral arterial disease?
AUse a hot water bottle on the feet at night
BCheck the feet daily and wear well-fitting shoes
CCut corns with a razor blade to prevent pressure
DWalk barefoot at home to strengthen the feet
2.Med-surg: cardiovascular & respiratoryHard
On day 2 after a surgical tracheostomy, the tube falls out. The patient is breathing but distressed. What should the nurse do first?
ALeave the patient alone while fetching a new tube
BCover the stoma completely with a sealed dressing and wait for help
CForce the tube back through the stoma immediately with firm pressure
DCall for expert help and give oxygen to both the face and the stoma
3.Med-surg: neuro, endocrine & renalMedium
After a change in the levothyroxine dose, when is the TSH usually rechecked?
AAfter about 2 years of treatment
BAfter 24 hours
CAfter 3 days
DAfter about 6–8 weeks
4.Med-surg: neuro, endocrine & renalHard
A patient in thyroid storm has a temperature of 40 °C (104 °F). Which measure for the fever is usually avoided?
AAspirin
BCooling blankets
CParacetamol (acetaminophen)
DFanning with cool air
5.Med-surg: GI, perioperative & oncologyMedium
What is the main clinical difference between small and large bowel obstruction?
AThere is no clinical difference; only a CT scan can tell them apart
BSmall bowel: marked distension only; large bowel: no pain, no vomiting and no distension at all
CSmall bowel: no vomiting at all; large bowel: early profuse vomiting with no distension
DSmall bowel: early vomiting, less distension; large bowel: later vomiting, marked distension
6.Med-surg: GI, perioperative & oncologyHard
A patient with advanced cancer who has capacity decides to stop chemotherapy. The family insists that treatment must continue. What should the nurse do?
ATell the patient that stopping is not allowed
BAsk the family to sign a new consent form
CSupport the patient's decision and help the team talk with the family
DContinue treatment because the family has asked for it
7.Clinical nursingMedium
An arterial blood gas shows a low pH, a high PaCO2 and a normal bicarbonate. What does this show?
AMetabolic acidosis
BRespiratory alkalosis
CMetabolic alkalosis
DRespiratory acidosis
8.Clinical nursingHard
A patient on metformin with reduced kidney function is due a CT scan with IV contrast. Why might metformin be withheld?
AMetformin reacts with the contrast to cause severe hyperglycaemia
BMetformin makes the images blurry
CMetformin causes severe bleeding during scans
DThere is a risk of lactic acidosis if kidney function worsens
9.Lab values & electrolytesMedium
A nurse completed the hepatitis B vaccine series. Which result shows protective immunity?
AA positive IgM anti-HBc
BA positive HBsAg test
CAnti-HBs of 10 mIU/mL or more
DA raised ALT level
10.Lab values & electrolytesHard
A patient with ongoing hemolytic anemia has an HbA1c of 4.6%, but home glucose readings are often 180–220 mg/dL (10–12 mmol/L). What best explains the gap?
AThe home glucose meter is reading falsely high
BShort red cell life span lowers the HbA1c falsely
CHemolysis makes the HbA1c test read too high
DThe patient has true, well-controlled diabetes
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 6 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 6 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.21, PaCO₂ 18 mmHg (2.4 kPa), HCO₃⁻ 7 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.21PaCO₂ 18 mmHg (2.4 kPa)HCO₃⁻ 7 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Fridericia’s formula QTc = QT/∛RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1supraventricular tachycardia (SVT)
2ventricular fibrillation
3idioventricular rhythm
4torsades de pointes
15.Prioritization & delegationMedium
A patient arrives in the recovery room after general anesthesia. What does the nurse assess first?
AThe surgical dressing and the drains
BThe pain score
CAirway patency and breathing
DUrine output
16.Prioritization & delegationHard
At the end of a shift, the nurse’s relief has not arrived and the patients are acutely ill. What should the nurse do?
ALeave on time, because the shift has officially ended
BLeave a written note at the station and go home
CAsk a nursing assistant to watch the patients until someone comes
DStay and tell the charge nurse, and hand over before leaving
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · Check the feet daily and wear well-fitting shoes
Why this is the answer
Reduced blood flow slows healing, so minor injuries can become ulcers or gangrene. Patients inspect their feet daily, keep them clean and moisturised, wear well-fitting footwear and see a podiatrist for nails and corns. Direct heat can burn ischaemic skin.
Answer
B · Check the feet daily and wear well-fitting shoes
2.Med-surg: cardiovascular & respiratory
Answer: D · Call for expert help and give oxygen to both the face and the stoma
Why this is the answer
In the first days after a tracheostomy, the tract is immature and the tube can easily be misplaced into the tissues. Emergency guidance is to call for an airway expert, apply oxygen to face and stoma and assess breathing. Reinsertion is done only by trained staff.
Answer
D · Call for expert help and give oxygen to both the face and the stoma
3.Med-surg: neuro, endocrine & renal
Answer: D · After about 6–8 weeks
Why this is the answer
Levothyroxine has a half-life of about a week, so it takes several weeks to reach a new steady state. TSH is usually rechecked about 6–8 weeks after a dose change.
Answer
D · After about 6–8 weeks
4.Med-surg: neuro, endocrine & renal
Answer: A · Aspirin
Why this is the answer
Aspirin (salicylates) displaces thyroid hormone from binding proteins, raising free hormone levels. Paracetamol (acetaminophen) and external cooling are used instead, together with treatment for the storm itself.
Answer
A · Aspirin
5.Med-surg: GI, perioperative & oncology
Answer: D · Small bowel: early vomiting, less distension; large bowel: later vomiting, marked distension
Why this is the answer
In proximal small bowel obstruction, vomiting is early and prominent and distension mild. In large bowel obstruction, distension is marked, constipation early and vomiting later (and may be faeculent). Imaging confirms the level and cause.
Answer
D · Small bowel: early vomiting, less distension; large bowel: later vomiting, marked distension
6.Med-surg: GI, perioperative & oncology
Answer: C · Support the patient's decision and help the team talk with the family
Why this is the answer
A competent adult can refuse treatment. The nurse advocates for the patient, supports communication with the family and team, and helps plan symptom control and palliative care.
Answer
C · Support the patient's decision and help the team talk with the family
7.Clinical nursing
Answer: D · Respiratory acidosis
Why this is the answer
A raised PaCO2 with a low pH means the lungs are not removing enough CO2, for example from hypoventilation. A normal bicarbonate suggests it is acute.
Answer
D · Respiratory acidosis
8.Clinical nursing
Answer: D · There is a risk of lactic acidosis if kidney function worsens
Why this is the answer
Iodinated contrast can worsen kidney function, and metformin can then accumulate and cause lactic acidosis. Local policy guides when to stop and restart it.
Answer
D · There is a risk of lactic acidosis if kidney function worsens
9.Lab values & electrolytes
Answer: C · Anti-HBs of 10 mIU/mL or more
Why this is the answer
An anti-HBs level of at least 10 mIU/mL after vaccination indicates protection. HBsAg and IgM anti-HBc indicate infection, not immunity. Health care workers are often tested after vaccination.Checked against:Hepatitis virus panel · MedlinePlus (NIH) (2024)
Answer
C · Anti-HBs of 10 mIU/mL or more
10.Lab values & electrolytes
Answer: B · Short red cell life span lowers the HbA1c falsely
Why this is the answer
HbA1c reflects glucose attached to hemoglobin over the red cell life span. In hemolysis, red cells are younger and have less time to bind glucose, so HbA1c is falsely low. Glucose monitoring or other markers are used instead.Checked against:The A1C Test & Diabetes · NIDDK (NIH) (2018); Hemoglobin A1C (HbA1c) Test · MedlinePlus (NIH) (2025)
Answer
B · Short red cell life span lowers the HbA1c falsely
11.Arterial blood gas interpretation
Answer: PaCO₂ = 17 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·6 + 8 = 17 mmHg
range: 15–19 mmHg
Answer
PaCO₂ = 17 mmHg
12.Arterial blood gas interpretation
Answer: appropriate compensation
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·7 + 8 = 18.5 → 16.5–20.5 mmHg
Compare
measured: 18 mmHg → appropriate compensation
Answer
appropriate compensation
13.ECG rhythm strip interpretation
Answer: QTc = 0.405 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 10 × 0.04 = 0.40 s
RR = 24 × 0.04 = 0.96 s
Fridericia’s formula
QTc = 0.40/∛0.96 = 0.40/0.9865 = 0.405 s
Answer
QTc = 0.405 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (405 ms)
14.ECG rhythm strip interpretation
Answer: torsades de pointes
More ventricular rhythms: torsades de pointes is a polymorphic ventricular tachycardia, usually 150–250/min, in which the wide complexes change in height and twist around the baseline, pointing up for a few beats and then down. Textbooks link it to a prolonged QT interval, and magnesium sulfate is the drug resuscitation guidelines name for it. An idioventricular rhythm is a ventricular escape rhythm: regular, wide QRS (0.12 s or more), no P waves, at 20–40/min (an accelerated idioventricular rhythm runs at 40–100/min). Monomorphic VT has identical wide complexes at more than 100/min. VF is chaotic, without any repeating complex.
Five steps
1. Rate: very fast, the complexes are about 6 small boxes apart (about 250 per minute).
2. Rhythm: fast and roughly regular, but the height and direction of the complexes change in a repeating spindle pattern.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: wide and polymorphic; the complexes twist around the baseline, pointing up for a few beats and then down.
Interpretation
torsades de pointes
Answer
torsades de pointes
Torsades de pointes is a polymorphic VT linked to a prolonged QT interval. This is identification practice only.
15.Prioritization & delegation
Answer: C · Airway patency and breathing
Why this is the answer
After anesthesia, the airway can be blocked by the tongue or secretions, and breathing may be depressed. The airway and breathing are checked first, followed by circulation and the wound.
Answer
C · Airway patency and breathing
16.Prioritization & delegation
Answer: D · Stay and tell the charge nurse, and hand over before leaving
Why this is the answer
The nurse must not leave patients without handing over to another qualified nurse. Telling the charge nurse allows staffing to be arranged safely.
Answer
D · Stay and tell the charge nurse, and hand over before leaving