Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Why should a long-acting beta-2 agonist (LABA) never be used alone in asthma?
AIt works only when it is taken together with a course of antibiotics
BWithout an inhaled steroid, it is linked with severe and fatal attacks
CIt always causes immediate severe bronchospasm when used on its own
DIt cannot be inhaled without a nebuliser
2.Med-surg: cardiovascular & respiratoryHard
A patient receiving weeks of IV antibiotics through a PICC line in the left arm develops swelling and aching of that arm and neck veins that look fuller on the left. What should the nurse suspect?
AA local skin allergy to the dressing
BA catheter-related deep vein thrombosis
CLymphoedema from lying in bed
DAn expected effect of the antibiotic
3.Med-surg: neuro, endocrine & renalMedium
How do DPP-4 inhibitors such as sitagliptin work?
AThey prolong the action of gut incretin hormones
BThey replace insulin that the pancreas cannot make
CThey block glucose reabsorption in the kidney
DThey stop the gut from absorbing fat
4.Med-surg: neuro, endocrine & renalHard
A patient taking an SGLT2 inhibitor is booked for major surgery. Which statement is correct?
ASurgery is not possible in patients taking this drug
BIt is usually paused in the days before surgery
CThe drug must be taken right up until the operation starts
DThe dose is usually doubled on the morning of surgery
5.Med-surg: GI, perioperative & oncologyMedium
Which statement about pain relief in acute pancreatitis is correct?
AOpioids can be used, and good analgesia is a priority
BPain relief should be withheld until the diagnosis is certain
COpioids must never be used in pancreatitis
DOnly paracetamol may be given
6.Med-surg: GI, perioperative & oncologyHard
Two days after surgery, a patient on regular ibuprofen has a low urine output and a rising creatinine, and intake has been poor. What should the nurse do?
AWithhold the next dose and report to the prescriber
BChange to a higher-strength NSAID tablet
CGive the next dose with extra food
DIncrease the dose to treat the pain better and encourage fluids
7.Clinical nursingMedium
Which is a major risk factor for Clostridioides difficile infection?
AA diet high in fibre and fresh fruit
BRecent broad-spectrum antibiotic use
CTaking regular paracetamol
DRegular exercise
8.Clinical nursingHard
Four call bells ring at the same time. Which patient should the nurse see first?
AA patient asking what time they will be discharged
BA patient who needs help to go to the toilet and has rung twice
CA patient who has just become breathless after starting an IV antibiotic
DA patient asking for pain relief for chronic back pain that they rate as 3/10
9.Lab values & electrolytesMedium
A urine culture is ordered for a patient with an indwelling urinary catheter. How should the nurse collect the sample?
ARemove the catheter and culture the catheter tip
BPour urine from the drainage bag into a sterile cup
CAspirate from the sampling port with a sterile syringe
DDisconnect the catheter from the tubing and let it drain
10.Lab values & electrolytesHard
Why can a normal creatinine be misleading in a frail older adult with low muscle mass?
ACreatinine levels do not depend on muscle mass at all
BOlder adults always have a higher creatinine than younger adults do
CA normal creatinine always proves normal kidney function
DLess muscle makes less creatinine, hiding reduced kidney function
11.Arterial blood gas interpretationMedium
A practice gas shows PaCO₂ 25 mmHg (3.3 kPa). Use the rule that in chronic respiratory alkalosis HCO₃⁻ falls by 5 mmol/L for every 10 mmHg that PaCO₂ is below 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
A practice gas shows pH 7.32, PaCO₂ 28 mmHg (3.7 kPa) and HCO₃⁻ 14 mmol/L, with Na⁺ 144 and Cl⁻ 106 mmol/L. Use the anion gap and the delta ratio to click the best interpretation.
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1ventricular fibrillation
2supraventricular tachycardia (SVT)
3ventricular tachycardia
4atrial flutter, 2:1 conduction
15.Prioritization & delegationMedium
Which patient is at the highest risk of falling?
AA 45-year-old with asthma who is alert and independent
BAn 84-year-old taking a diuretic who has fallen before and gets up at night
CA 30-year-old after an appendectomy who walks with steady steps
DA 60-year-old admitted for chest pain that has since been ruled out by tests
16.Prioritization & delegationHard
A chemical cleaning fluid splashes into a patient’s eye. What should the nurse do first?
AGive antibiotic eye drops first
BCover the eye with a dry patch and wait for the provider
CFlush the eye with plenty of water or saline straight away
DRub the eye gently with a clean tissue to remove the chemical
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · Without an inhaled steroid, it is linked with severe and fatal attacks
Why this is the answer
LABA monotherapy in asthma is linked with severe attacks and asthma deaths because it relieves symptoms while airway inflammation continues. In asthma, LABAs are always given with an inhaled corticosteroid, often in one combination inhaler.
Answer
B · Without an inhaled steroid, it is linked with severe and fatal attacks
2.Med-surg: cardiovascular & respiratory
Answer: B · A catheter-related deep vein thrombosis
Why this is the answer
Upper-limb DVT is a recognised complication of PICCs and other central lines. Arm swelling, pain and distended veins should be reported, and an ultrasound arranged. The line is not flushed forcefully, and treatment usually involves anticoagulation.
Answer
B · A catheter-related deep vein thrombosis
3.Med-surg: neuro, endocrine & renal
Answer: A · They prolong the action of gut incretin hormones
Why this is the answer
DPP-4 inhibitors slow the breakdown of incretins such as GLP-1, so more insulin is released and less glucagon after meals. They rarely cause hypoglycaemia on their own and are weight-neutral.
Answer
A · They prolong the action of gut incretin hormones
4.Med-surg: neuro, endocrine & renal
Answer: B · It is usually paused in the days before surgery
Why this is the answer
Fasting, surgery and dehydration increase the risk of euglycaemic DKA with SGLT2 inhibitors. Guidance usually advises stopping them in the days before major surgery and restarting when the patient is eating and drinking normally.
Answer
B · It is usually paused in the days before surgery
5.Med-surg: GI, perioperative & oncology
Answer: A · Opioids can be used, and good analgesia is a priority
Why this is the answer
Acute pancreatitis is very painful, and opioids are used as part of multimodal analgesia. There is no good evidence that they worsen the condition. Sedation and breathing are monitored.
Answer
A · Opioids can be used, and good analgesia is a priority
6.Med-surg: GI, perioperative & oncology
Answer: A · Withhold the next dose and report to the prescriber
Why this is the answer
NSAIDs can cause acute kidney injury, particularly with hypovolaemia, older age or other nephrotoxic drugs. The nurse withholds and reports, and fluid status and other analgesia are reviewed.
Answer
A · Withhold the next dose and report to the prescriber
7.Clinical nursing
Answer: B · Recent broad-spectrum antibiotic use
Why this is the answer
Broad-spectrum antibiotics disrupt normal gut flora, letting C. difficile overgrow. Older age, hospital stay and proton pump inhibitors also increase the risk.
Answer
B · Recent broad-spectrum antibiotic use
8.Clinical nursing
Answer: C · A patient who has just become breathless after starting an IV antibiotic
Why this is the answer
Breathlessness soon after a new IV antibiotic suggests possible anaphylaxis, an airway and breathing emergency. The infusion should be stopped and the patient assessed immediately.
Answer
C · A patient who has just become breathless after starting an IV antibiotic
9.Lab values & electrolytes
Answer: C · Aspirate from the sampling port with a sterile syringe
Why this is the answer
The catheter sampling port is cleaned and urine is aspirated with a sterile syringe, keeping the system closed. Urine in the drainage bag has been standing and can contain bacteria that multiplied there; opening the system raises the risk of infection.
Answer
C · Aspirate from the sampling port with a sterile syringe
10.Lab values & electrolytes
Answer: D · Less muscle makes less creatinine, hiding reduced kidney function
Why this is the answer
Creatinine is made by muscle. A person with little muscle makes little creatinine, so the value can look normal even when kidney function is reduced. Creatinine-based eGFR can overestimate function in the same way, so a measured creatinine clearance or a cystatin C–based estimate may be used when dosing drugs cleared by the kidneys.Checked against:Creatinine blood test · MedlinePlus (NIH) (2025)
Answer
D · Less muscle makes less creatinine, hiding reduced kidney function
11.Arterial blood gas interpretation
Answer: HCO₃⁻ = 16.5 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|25 − 40| = 15 mmHg → 1.5 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 − 5·1.5 = 16.5 mmol/L
Answer
HCO₃⁻ = 16.5 mmol/L
12.Arterial blood gas interpretation
Answer: pure high-gap acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 144 − (106 + 14) = 24
Delta ratio
(24 − 12)/(24 − 14) = 1.2
pure high-gap acidosis
Answer
pure high-gap acidosis
13.ECG rhythm strip interpretation
Answer: QTc = 0.49 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 12.5 × 0.04 = 0.50 s
RR = 26 × 0.04 = 1.04 s
Bazett’s formula
QTc = 0.50/√1.04 = 0.50/1.02 = 0.49 s
Answer
QTc = 0.49 s
Above the usual limits for both men (about 0.45 s) and women (about 0.46 s): prolonged. (490 ms)
14.ECG rhythm strip interpretation
Answer: ventricular tachycardia
Ventricular rhythms: ventricular tachycardia is a run of three or more wide (0.12 s or more) complexes in a row at more than 100/min, usually 150–250/min, regular, without related P waves. Ventricular fibrillation is a chaotic, irregular waveform with no identifiable P waves, QRS complexes or T waves and no countable rate. Asystole is an almost flat line with no ventricular activity; a flat line is always confirmed by checking the patient, the leads and the gain and a second lead. In resuscitation guidelines VF and pulseless VT are the shockable rhythms and asystole is not.
Five steps
1. Rate: R–R = 10 small boxes, 1500 ÷ 10 ≈ 150 per minute.
2. Rhythm: regular, every R–R is 0.40 s.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: 0.14 s, wide (0.12 s or more).
Interpretation
ventricular tachycardia
Answer
ventricular tachycardia
In resuscitation guidelines VF and pulseless VT are the shockable rhythms. This is identification practice only.
15.Prioritization & delegation
Answer: B · An 84-year-old taking a diuretic who has fallen before and gets up at night
Why this is the answer
A previous fall is one of the strongest risk factors. Older age, diuretics and getting up at night to urinate add further risk, so this patient needs fall precautions.
Answer
B · An 84-year-old taking a diuretic who has fallen before and gets up at night
16.Prioritization & delegation
Answer: C · Flush the eye with plenty of water or saline straight away
Why this is the answer
Chemical eye injuries are treated by immediate, continuous irrigation with large amounts of water or saline. Delay, rubbing or a patch allows more damage.
Answer
C · Flush the eye with plenty of water or saline straight away