Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Which feature of a COPD exacerbation most suggests that antibiotics are needed?
AA dry, tickly cough with no sputum at all for a day
BA mild sore throat that lasted for one day only
CA clear runny nose
DAn increase in purulent (green or yellow) sputum
2.Med-surg: cardiovascular & respiratoryHard
A patient taking warfarin for AF falls and hits their head. An hour later they are drowsy and have vomited. What is the priority?
AWithhold tonight's warfarin and review tomorrow
BEncourage sleep and check observations at the next routine time
CUrgent escalation for CT of the head and anticoagulant reversal
DGive paracetamol (acetaminophen) and a light meal
3.Med-surg: neuro, endocrine & renalMedium
Why must Parkinson's medicines be given on time in hospital?
AGiving them on time prevents the disease from getting worse
BLate doses build up in the blood and cause an overdose
CLate doses cause the patient to develop high blood glucose
DLate doses can soon cause stiffness, falls and poor swallowing
4.Med-surg: neuro, endocrine & renalHard
A patient's chronic hyponatraemia was corrected from 115 to 132 mmol/L in 24 hours. Two days later they develop slurred speech, difficulty swallowing and limb weakness. What is the most likely cause?
AOsmotic demyelination syndrome
BA new stroke unrelated to the sodium
CHypoglycaemia from poor intake
DNormal recovery from hyponatraemia
5.Med-surg: GI, perioperative & oncologyMedium
Which long-term effect must be monitored in patients receiving anthracyclines such as doxorubicin?
AExcess growth of body hair
BDamage to the heart muscle
CLoss of the sense of smell
DPermanent high blood glucose
6.Med-surg: GI, perioperative & oncologyHard
After a fall, a patient with advanced dementia is agitated, grimacing and guarding the hip, and cannot rate the pain. What should the nurse do?
AGive a sedative to treat the agitation and avoid giving any analgesia
BWait until a relative can confirm the pain
CAssume there is no pain because none is reported
DUse an observational pain tool, give analgesia and reassess
7.Clinical nursingMedium
When giving insulin, which statement is correct?
ARotate injection sites to avoid lipohypertrophy
BInsulin should be shaken hard before use
CRapid-acting insulin is given only at bedtime
DAlways inject into the same spot for consistent absorption
8.Clinical nursingHard
A patient with full mental capacity decides against a treatment that the team thinks is best. What does the Mental Capacity Act 2005 (England and Wales) say?
AThe patient must be assessed by a psychiatrist before refusing
BThe team may override any decision that it disagrees with if it is serious
CA person is not treated as lacking capacity just because they make an unwise decision
DThe family may make the decision instead if they disagree with the patient's choice
9.Lab values & electrolytesMedium
A patient with suspected pulmonary TB needs sputum samples for acid-fast bacilli. Which instruction is correct?
AGive several samples of nasal mucus blown into a tissue
BGive several deep-cough samples, often first thing in the morning
CGive one sample of saliva collected from the mouth at any time of day
DGive one sample after brushing with mouthwash so it is clean
10.Lab values & electrolytesHard
A patient started methimazole for hyperthyroidism 6 weeks ago and now has a fever and a severe sore throat. Which action is most important?
AHold the drug and arrange an urgent white cell and neutrophil count
BGive the next dose and suggest warm salt-water gargles for comfort
CCheck the TSH and double the dose if it is still low
DAdvise the patient to continue the drug and drink more fluid
11.Arterial blood gas interpretationMedium
Practice values: Na⁺ 135 mmol/L, glucose 5.1 mmol/L and urea 17.9 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 135 mmol/Lglucose 5.1 mmol/Lurea 17.9 mmol/L
Osm = mOsm/kg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic alkalosis with HCO₃⁻ 34 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 34 mmol/L
PaCO₂ = mmHg
13.ECG rhythm strip interpretationMedium
Measure the QT interval on this lead II strip, in seconds.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QT = s
14.ECG rhythm strip interpretationHard
This lead II strip shows a conduction problem between the atria and the ventricles. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1second-degree AV block type I (Wenckebach)
2third-degree (complete) AV block
3junctional rhythm
4first-degree AV block
15.Prioritization & delegationMedium
An Rh-negative mother has just given birth to an Rh-positive baby. What does the nurse expect to give the mother?
AA dose of the hepatitis B vaccine instead
BVitamin K to the mother
CNo treatment is needed
DRh immunoglobulin within 72 hours
16.Prioritization & delegationHard
A patient with COPD on 2 L/min oxygen becomes drowsy and hard to wake. The SpO₂ is 93%. What is the priority?
ALet the patient sleep, because the saturation is above target
BAssess breathing and escalate for a blood gas, as carbon dioxide may be rising
CGive the as-needed sedative so the patient rests comfortably
DIncrease the oxygen to 6 L/min so that the saturation goes even higher than now
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: D · An increase in purulent (green or yellow) sputum
Why this is the answer
Antibiotics are usually considered when sputum becomes more purulent, especially with more breathlessness or sputum volume, or signs of pneumonia. Many exacerbations are viral. Oral corticosteroids and increased bronchodilators are also used.
Answer
D · An increase in purulent (green or yellow) sputum
2.Med-surg: cardiovascular & respiratory
Answer: C · Urgent escalation for CT of the head and anticoagulant reversal
Why this is the answer
Head injury in an anticoagulated patient with drowsiness or vomiting suggests intracranial haemorrhage. Urgent CT, neurological observations, an INR and rapid reversal (for warfarin, prothrombin complex concentrate and IV vitamin K) are needed.
Answer
C · Urgent escalation for CT of the head and anticoagulant reversal
3.Med-surg: neuro, endocrine & renal
Answer: D · Late doses can soon cause stiffness, falls and poor swallowing
Why this is the answer
People with Parkinson's disease often take doses at exact times. A delay of even 30 minutes or so can cause rigidity, immobility, falls and unsafe swallowing. Many hospitals treat these drugs as time-critical.
Answer
D · Late doses can soon cause stiffness, falls and poor swallowing
4.Med-surg: neuro, endocrine & renal
Answer: A · Osmotic demyelination syndrome
Why this is the answer
Rapid correction of chronic hyponatraemia shrinks brain cells and can damage the myelin of the pons and other areas. Symptoms (dysarthria, dysphagia, quadriparesis, "locked-in" state) appear days later. This is why correction rates are limited and sodium is monitored closely.
Answer
A · Osmotic demyelination syndrome
5.Med-surg: GI, perioperative & oncology
Answer: B · Damage to the heart muscle
Why this is the answer
Anthracyclines can cause cumulative, dose-related cardiomyopathy and heart failure. Cardiac function is checked before and during treatment, and a lifetime dose limit is applied.
Answer
B · Damage to the heart muscle
6.Med-surg: GI, perioperative & oncology
Answer: D · Use an observational pain tool, give analgesia and reassess
Why this is the answer
In dementia, pain often appears as agitation or guarding. An observational tool supports assessment; analgesia is given and effect reassessed. The hip is also assessed for injury such as a fracture.
Answer
D · Use an observational pain tool, give analgesia and reassess
7.Clinical nursing
Answer: A · Rotate injection sites to avoid lipohypertrophy
Why this is the answer
Rotating sites prevents fatty lumps that make absorption unpredictable. Cloudy insulins are mixed by gentle rolling, not shaking.
Answer
A · Rotate injection sites to avoid lipohypertrophy
8.Clinical nursing
Answer: C · A person is not treated as lacking capacity just because they make an unwise decision
Why this is the answer
One of the Act's principles is that making an unwise decision is not, on its own, evidence of incapacity. The team should check understanding, explore reasons and document the discussion.
Answer
C · A person is not treated as lacking capacity just because they make an unwise decision
9.Lab values & electrolytes
Answer: B · Give several deep-cough samples, often first thing in the morning
Why this is the answer
Usually a series of three sputum samples is collected, at least one in the early morning, when secretions have pooled overnight. The patient rinses with water (not mouthwash), takes deep breaths and coughs deeply to bring up sputum, not saliva. Airborne precautions are used.Checked against:Sputum Culture · MedlinePlus (NIH) (2024); Acid-Fast Bacillus (AFB) Tests · MedlinePlus (NIH) (2025)
Answer
B · Give several deep-cough samples, often first thing in the morning
10.Lab values & electrolytes
Answer: A · Hold the drug and arrange an urgent white cell and neutrophil count
Why this is the answer
Methimazole and propylthiouracil can cause agranulocytosis, often in the first months of therapy. Fever or sore throat must be reported at once; the drug is held and a CBC with differential is checked. Infection is treated urgently if neutrophils are low.
Answer
A · Hold the drug and arrange an urgent white cell and neutrophil count
11.Arterial blood gas interpretation
Answer: Osm = 293 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·135 + 5.1 + 17.9 = 293 ≈ 293 mOsm/kg
Answer
Osm = 293 mOsm/kg
12.Arterial blood gas interpretation
Answer: PaCO₂ = 44.8 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·34 + 21 = 44.8 mmHg
Answer
PaCO₂ = 44.8 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
13.ECG rhythm strip interpretation
Answer: QT = 0.4 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
10 small boxes from the start of the QRS to the end of the T wave
Convert
QT = 10 × 0.04 s = 0.4 s
Answer
QT = 0.4 s
A rough rule: at normal rates the QT should be less than half the R–R interval (here R–R = 0.76 s).
14.ECG rhythm strip interpretation
Answer: third-degree (complete) AV block
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Five steps
1. Rate: R–R = 42 small boxes, 1500 ÷ 42 ≈ 36 per minute.
2. Rhythm: R–R regular (1.68 s) and P–P regular (0.76 s), but the two are independent.
3. P waves: upright and regular at 79 per minute, but not linked to the QRS complexes; some hide in a QRS or a T wave.
4. PR interval: varies from beat to beat; there is no fixed relation.
5. QRS: 0.14 s, wide (0.12 s or more).
Interpretation
third-degree (complete) AV block
Answer
third-degree (complete) AV block
Type II and third-degree blocks are the ones that can suddenly progress, so textbooks rank them as more serious than type I.
15.Prioritization & delegation
Answer: D · Rh immunoglobulin within 72 hours
Why this is the answer
Rh immunoglobulin given within 72 hours of birth prevents the mother from forming anti-D antibodies, which could harm a future Rh-positive baby.
Answer
D · Rh immunoglobulin within 72 hours
16.Prioritization & delegation
Answer: B · Assess breathing and escalate for a blood gas, as carbon dioxide may be rising
Why this is the answer
In COPD, drowsiness can be a sign of carbon dioxide retention (hypercapnia), even when the saturation is acceptable. The nurse assesses breathing, escalates and avoids extra oxygen or sedatives that could worsen it.
Answer
B · Assess breathing and escalate for a blood gas, as carbon dioxide may be rising