Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Which combination of drug classes improves survival in heart failure with reduced ejection fraction?
AAn NSAID, aspirin, a statin and a thiazide diuretic
BLoop diuretic, digoxin, nitrate and a calcium channel blocker
CACE inhibitor or ARNI, beta-blocker, MRA and SGLT2 inhibitor
DA loop diuretic alone at the highest tolerated dose
2.Med-surg: cardiovascular & respiratoryHard
After cardiac catheterisation via the radial artery, which assessment is most important?
APupil size and reaction to light every 15 minutes
BUrine specific gravity every four hours
CCirculation, sensation and movement of the hand, and the site
DBowel sounds and abdominal girth every hour after the test
3.Med-surg: neuro, endocrine & renalMedium
A patient with severe vomiting and diarrhoea takes ramipril, furosemide and metformin. Which advice is correct?
ADouble the furosemide to prevent fluid retention
BPause these medicines until eating and drinking again
CAdd ibuprofen to treat the abdominal cramps
DKeep taking everything as normal and drink less
4.Med-surg: neuro, endocrine & renalHard
A patient in a halo vest for a cervical spine fracture has a cardiac arrest. What must be immediately available?
AA pillow to raise the head and shoulders
BScissors to cut through the skull pins
CA hard board to slide under the vest
DThe tool to open the front of the vest for CPR
5.Med-surg: GI, perioperative & oncologyMedium
During the first infusion of a monoclonal antibody such as rituximab, which problem is most important to watch for?
ASevere constipation within the first hour of starting the infusion
BAn infusion reaction, such as fever, rigors or breathlessness
CSudden hair loss during the infusion
DA rise in platelet count above normal
6.Med-surg: GI, perioperative & oncologyHard
Which management is generally recommended for stable, dry, intact black eschar on the heel of a patient with poor circulation?
ARemove it with sharp debridement at the bedside today
BLeave it intact, offload the heel and refer for review
CCover it with a tight compression bandage
DSoak it in water every day to soften it
7.Clinical nursingMedium
Before giving a beta-blocker, which observation is most important to check?
ATemperature only
BBowel movements
CHeart rate and blood pressure
DBlood glucose only
8.Clinical nursingHard
An older patient's blood pressure is 142/80 mmHg lying and 116/72 mmHg after standing for three minutes, and they feel dizzy. What does this show?
ANormal blood pressure variation
BWhite coat hypertension
CHypertensive emergency
DPostural hypotension
9.Lab values & electrolytesMedium
A healthy patient's result is slightly outside the laboratory reference range, and all other results are normal. Which statement best explains why this can happen?
AReference ranges include every healthy person without exception
BAny result outside the range always means disease is present
CReference ranges are the same in every laboratory worldwide
DRanges cover about 95% of healthy people, so some fall outside
10.Lab values & electrolytesHard
A patient has a sodium of 150 mEq/L, a glucose of 180 mg/dL and a BUN of 28 mg/dL. Using the formula 2 × Na + glucose/18 + BUN/2.8, what is the calculated serum osmolality?
AAbout 285 mOsm/kg, which is normal
BAbout 358 mOsm/kg, which is high
CAbout 300 mOsm/kg, which is normal
DAbout 320 mOsm/kg, which is high
11.Arterial blood gas interpretationMedium
A practice gas shows PaCO₂ 78 mmHg (10.4 kPa). Use the rule that in chronic respiratory acidosis HCO₃⁻ rises by 3.5 mmol/L for every 10 mmHg that PaCO₂ is above 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
Practice values: Na⁺ 142, Cl⁻ 91 and HCO₃⁻ 14 mmol/L. Calculate the delta ratio (AG − 12)/(24 − HCO₃⁻), using AG = Na⁺ − (Cl⁻ + HCO₃⁻). Give two decimals.
Na⁺ 142 mmol/LCl⁻ 91 mmol/LHCO₃⁻ 14 mmol/L
delta ratio =
13.ECG rhythm strip interpretationMedium
This lead II strip shows sinus rhythm with one pause. Measure the pause, the R–R interval across it, in seconds.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
pause = s
14.ECG rhythm strip interpretationHard
This lead II strip shows a conduction problem between the atria and the ventricles. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1sinus bradycardia
2second-degree AV block type II
3third-degree (complete) AV block
4second-degree AV block type I (Wenckebach)
15.Prioritization & delegationMedium
When making patient assignments, what should the charge nurse consider first?
ALetting staff choose the patients they prefer
BGiving each nurse patients in rooms next to each other
CGiving the newest staff the most complex patients
DMatching each patient’s needs to staff competence
16.Prioritization & delegationHard
Which patient needs the nurse’s attention first?
AA patient with chronic back pain asking for a heat pack
BA patient with known migraines who has a headache like their usual ones
CA patient with long-standing hypertension whose blood pressure is 158/94 mmHg and who has no symptoms
DA patient who says this is “the worst headache of my life” that started suddenly, with a blood pressure of 170/100 mmHg
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · ACE inhibitor or ARNI, beta-blocker, MRA and SGLT2 inhibitor
Why this is the answer
Current guidelines recommend four disease-modifying classes for HFrEF: ACE inhibitor, ARB or ARNI (sacubitril/valsartan); an evidence-based beta-blocker; an MRA (spironolactone or eplerenone); and an SGLT2 inhibitor. Loop diuretics and digoxin improve symptoms but not survival. NSAIDs worsen heart failure.
Answer
C · ACE inhibitor or ARNI, beta-blocker, MRA and SGLT2 inhibitor
2.Med-surg: cardiovascular & respiratory
Answer: C · Circulation, sensation and movement of the hand, and the site
Why this is the answer
After radial access, the compression device and puncture site are checked for bleeding or haematoma, and the hand for colour, warmth, capillary refill, sensation and movement. Radial artery occlusion and forearm compartment syndrome are possible complications.
Answer
C · Circulation, sensation and movement of the hand, and the site
3.Med-surg: neuro, endocrine & renal
Answer: B · Pause these medicines until eating and drinking again
Why this is the answer
During dehydrating illness, ACE inhibitors, diuretics and metformin can worsen AKI or its complications. Sick-day guidance usually advises pausing them until the person is eating and drinking normally, and NSAIDs are avoided.
Answer
B · Pause these medicines until eating and drinking again
4.Med-surg: neuro, endocrine & renal
Answer: D · The tool to open the front of the vest for CPR
Why this is the answer
The tool to release the anterior vest is kept attached to the vest so it can be opened quickly for CPR or airway management. Pin sites need regular care to prevent infection, and the patient needs teaching about skin care under the vest.
Answer
D · The tool to open the front of the vest for CPR
5.Med-surg: GI, perioperative & oncology
Answer: B · An infusion reaction, such as fever, rigors or breathlessness
Why this is the answer
Infusion-related reactions are most common with the first dose. Premedication, a slow starting rate, close monitoring and readiness to stop the infusion and treat anaphylaxis are standard.
Answer
B · An infusion reaction, such as fever, rigors or breathlessness
6.Med-surg: GI, perioperative & oncology
Answer: B · Leave it intact, offload the heel and refer for review
Why this is the answer
Stable, dry eschar on an ischaemic heel acts as a biological barrier and should usually not be debrided. The heel is offloaded and the circulation assessed. If it becomes soft, boggy, red or draining, infection should be suspected and specialist review sought.
Answer
B · Leave it intact, offload the heel and refer for review
7.Clinical nursing
Answer: C · Heart rate and blood pressure
Why this is the answer
Beta-blockers lower heart rate and blood pressure, so bradycardia or hypotension may require withholding the dose and informing the prescriber.
Answer
C · Heart rate and blood pressure
8.Clinical nursing
Answer: D · Postural hypotension
Why this is the answer
A fall in systolic pressure of 20 mmHg or more (here 26 mmHg) on standing, especially with symptoms, indicates postural hypotension. Causes include medicines, dehydration and autonomic problems.
Answer
D · Postural hypotension
9.Lab values & electrolytes
Answer: D · Ranges cover about 95% of healthy people, so some fall outside
Why this is the answer
A reference range is usually the central 95% of results from a healthy population, so about 1 in 20 healthy people will have a value just outside it. The result is interpreted with the clinical picture and previous values, and repeated if needed.Checked against:How to Understand Your Lab Results · MedlinePlus (NIH) (2025)
Answer
D · Ranges cover about 95% of healthy people, so some fall outside
10.Lab values & electrolytes
Answer: D · About 320 mOsm/kg, which is high
Why this is the answer
Osmolality = 300 + 10 + 10 = 320 mOsm/kg, above the typical range of about 275–295 mOsm/kg. The high sodium is the main cause, which points to water loss or too little water intake.Checked against:Osmolality blood test · MedlinePlus (NIH) (2025)
Answer
D · About 320 mOsm/kg, which is high
11.Arterial blood gas interpretation
Answer: HCO₃⁻ = 37.3 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|78 − 40| = 38 mmHg → 3.8 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 + 3.5·3.8 = 37.3 mmol/L
Answer
HCO₃⁻ = 37.3 mmol/L
12.Arterial blood gas interpretation
Answer: delta ratio = 2.5
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 142 − (91 + 14) = 37
Delta ratio
(37 − 12)/(24 − 14) = 25/10 = 2.5
Answer
delta ratio = 2.5
Above 2: an added metabolic alkalosis.
13.ECG rhythm strip interpretation
Answer: pause = 1.8 s
Narrow-complex tachycardia and pauses: supraventricular tachycardia (SVT) is a regular tachycardia at about 150–250/min with narrow QRS complexes; the P waves are usually not visible because they are hidden in the QRS complex or the T wave. Sinus tachycardia in an adult at rest is usually below about 150/min and has a visible P wave before every QRS; atrial flutter with 2:1 conduction often runs at about 150/min and shows sawtooth waves. In sinus arrest the sinus node stops firing for a moment: a pause with no P wave and no QRS whose length is not a whole number of P–P cycles (a pause of exactly two or three cycles points to sinus exit block instead).
Measure
45 small boxes from R to R across the pause
Convert
pause = 45 × 0.04 s = 1.8 s
Compare with P–P
1.80 ÷ 0.80 ≈ 2.3 P–P cycles, not a whole number
Answer
pause = 1.8 s
No P wave appears in the pause, and the pause is not a whole number of P–P cycles: sinus arrest. A pause of exactly two or three cycles would point to sinus exit block.
14.ECG rhythm strip interpretation
Answer: second-degree AV block type II
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Five steps
1. Rate: 4 QRS complexes in 6 s, × 10 = 40 per minute.
2. Rhythm: the P waves are regular; R–R is regular except for a long pause where a QRS is missing.
3. P waves: upright and regular (P–P 0.92 s, 65 per minute); one P in every 3 is not followed by a QRS.
4. PR interval: constant at 0.20 s in the conducted beats.
5. QRS: 0.12 s, wide (0.12 s or more).
Interpretation
second-degree AV block type II
Answer
second-degree AV block type II
Type II and third-degree blocks are the ones that can suddenly progress, so textbooks rank them as more serious than type I.
15.Prioritization & delegation
Answer: D · Matching each patient’s needs to staff competence
Why this is the answer
Assignments are based mainly on patient acuity and needs and on each staff member’s skills and scope. Geography and continuity of care help, but they come after safety.
Answer
D · Matching each patient’s needs to staff competence
16.Prioritization & delegation
Answer: D · A patient who says this is “the worst headache of my life” that started suddenly, with a blood pressure of 170/100 mmHg
Why this is the answer
A sudden, severe “thunderclap” headache can mean a bleed in the brain, such as a subarachnoid hemorrhage, and is an emergency. The other patients have known, stable problems that match their history.
Answer
D · A patient who says this is “the worst headache of my life” that started suddenly, with a blood pressure of 170/100 mmHg