Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
How do clopidogrel and ticagrelor work?
AThey directly inhibit thrombin in the plasma
BThey inhibit the vitamin K-dependent clotting factors in the liver
CThey block the platelet ADP (P2Y12) receptor
DThey dissolve fibrin in existing clots
2.Med-surg: cardiovascular & respiratoryHard
A patient with infective endocarditis is on IV gentamicin with another antibiotic. Which monitoring is most important?
ADrug levels, renal function and hearing or balance changes
BBlood glucose only
CLiver size by daily palpation and weekly abdominal ultrasound
DPeak flow readings and spirometry before and after each dose
3.Med-surg: neuro, endocrine & renalMedium
A seizure has lasted five minutes and is continuing. What is the usual first-line drug treatment?
AA benzodiazepine such as IV lorazepam or buccal midazolam
BIM adrenaline into the outer thigh
CAn IV loading dose of phenytoin before anything else
DIV glucose 50% in every patient, then reassess
4.Med-surg: neuro, endocrine & renalHard
A patient with a severe head injury does not open the eyes, and in response to pain the arms extend and rotate inwards with the legs extended. What does this indicate?
AFlexor (decorticate) posturing, a sign of mild cortical injury
BA focal seizure that will stop without any treatment
CExtensor (decerebrate) posturing: severe brainstem injury
DA normal withdrawal response to a painful stimulus
5.Med-surg: GI, perioperative & oncologyMedium
Why is IV hydration given with cisplatin?
ATo prevent hair loss
BTo make the drug less effective
CTo raise the blood pressure during treatment
DTo protect the kidneys from damage
6.Med-surg: GI, perioperative & oncologyHard
On day 3 after surgery, a patient has a temperature of 38.6 °C, respiratory rate 24/min, pulse 118/min, BP 92/58 mmHg and new confusion. What should the nurse do?
AGive paracetamol and recheck in four hours
BEscalate urgently and start the sepsis pathway
CEncourage oral fluids and wait for the doctor's round
DRecord the observations and continue routine care
7.Clinical nursingMedium
What is the most common cause of hypernatraemia in frail older inpatients?
AToo much exercise
BTaking too many vitamins
CEating too much salt in one meal
DNot drinking enough water
8.Clinical nursingHard
Which action is correct when caring for a chest drain with an underwater seal?
AKeep the drainage bottle below the level of the chest
BClamp the tube routinely during every transfer or bed move
CLift the bottle above the patient to empty it
DRemove the water from the bottle to prevent spills
9.Lab values & electrolytesMedium
In the US, when is a pregnant woman without known risk factors usually screened for gestational diabetes?
AAt about 38–40 weeks of pregnancy
BAt about 24–28 weeks of pregnancy
COnly after the baby is born
DAt about 6–8 weeks of pregnancy
10.Lab values & electrolytesHard
A patient with diabetes and chronic kidney disease had a CT scan with IV contrast. Two days later, the creatinine has risen from 1.4 to 2.0 mg/dL (124 to 177 µmol/L). Which action is most appropriate?
AIgnore it, because contrast never affects kidney function
BReport it, monitor urine output and hold metformin until reviewed
CGive extra metformin, because the glucose rises after contrast
DRestrict all fluids to protect the kidneys from more contrast
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 14 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 14 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.23, PaCO₂ 22 mmHg (2.9 kPa), HCO₃⁻ 9 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.23PaCO₂ 22 mmHg (2.9 kPa)HCO₃⁻ 9 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This lead II strip shows an AV block, so the atria and the ventricles beat at different rates. Measure the P–P interval and find the atrial rate in beats per minute (1500 method, whole number).
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
atrial rate = bpm
15.Prioritization & delegationMedium
During an IV vancomycin infusion, a patient develops flushing and itching of the face and neck. What should the nurse do first?
AApply a warm compress to the face and neck
BIgnore it, because flushing is always harmless and passes
CStop or slow the infusion and inform the provider
DSpeed up the infusion to finish it quickly
16.Prioritization & delegationHard
Which patient is the best choice to move out of intensive care to make room for a new admission?
AOn a norepinephrine infusion whose dose was increased this morning
BIntubated 1 hour ago for respiratory failure, still sedated
CAdmitted overnight with a GI bleed and still receiving blood
DExtubated 2 days ago, stable on 2 L/min nasal oxygen, no vasoactive infusions
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · They block the platelet ADP (P2Y12) receptor
Why this is the answer
Clopidogrel, prasugrel and ticagrelor block the P2Y12 ADP receptor on platelets, reducing aggregation. With aspirin, they form dual antiplatelet therapy after acute coronary syndromes and stents. Warfarin inhibits vitamin K-dependent factors; dabigatran inhibits thrombin.
Answer
C · They block the platelet ADP (P2Y12) receptor
2.Med-surg: cardiovascular & respiratory
Answer: A · Drug levels, renal function and hearing or balance changes
Why this is the answer
Gentamicin is nephrotoxic and ototoxic. Levels are measured to guide dosing, renal function is checked regularly and patients are asked about tinnitus, hearing loss and dizziness. Risk is greater with loop diuretics, older age and longer courses.
Answer
A · Drug levels, renal function and hearing or balance changes
3.Med-surg: neuro, endocrine & renal
Answer: A · A benzodiazepine such as IV lorazepam or buccal midazolam
Why this is the answer
A seizure lasting five minutes or more (or repeated seizures without recovery) is treated as status epilepticus. A benzodiazepine is given first (IV lorazepam if access is available; buccal or intranasal midazolam or rectal diazepam if not), then a second-line antiseizure drug such as levetiracetam, phenytoin or valproate if the seizure continues. Glucose is checked and given only if low.
Answer
A · A benzodiazepine such as IV lorazepam or buccal midazolam
4.Med-surg: neuro, endocrine & renal
Answer: C · Extensor (decerebrate) posturing: severe brainstem injury
Why this is the answer
Abnormal extension to pain (GCS motor score 2) indicates severe injury at or near the brainstem and carries a worse prognosis than abnormal flexion (decorticate posturing, motor score 3). Any new abnormal posturing needs immediate escalation.
Answer
C · Extensor (decerebrate) posturing: severe brainstem injury
5.Med-surg: GI, perioperative & oncology
Answer: D · To protect the kidneys from damage
Why this is the answer
Cisplatin is nephrotoxic, so hydration and electrolyte replacement (especially magnesium) are given. It can also cause ototoxicity, neuropathy and severe nausea.
Answer
D · To protect the kidneys from damage
6.Med-surg: GI, perioperative & oncology
Answer: B · Escalate urgently and start the sepsis pathway
Why this is the answer
These findings suggest sepsis with poor perfusion. Urgent medical review and a sepsis bundle, including blood cultures, antibiotics within an hour, lactate, fluids and urine output monitoring, improve survival.
Answer
B · Escalate urgently and start the sepsis pathway
7.Clinical nursing
Answer: D · Not drinking enough water
Why this is the answer
Hypernatraemia usually reflects water deficit, often in patients who are confused, unable to drink independently or losing fluid through fever or diarrhoea. Supporting fluid intake prevents it.
Answer
D · Not drinking enough water
8.Clinical nursing
Answer: A · Keep the drainage bottle below the level of the chest
Why this is the answer
The bottle stays below chest level so fluid and air cannot return to the pleural space. Routine clamping can cause a tension pneumothorax.
Answer
A · Keep the drainage bottle below the level of the chest
9.Lab values & electrolytes
Answer: B · At about 24–28 weeks of pregnancy
Why this is the answer
Placental hormones increase insulin resistance in the second half of pregnancy, so US guidance recommends screening all women at 24–28 weeks, with earlier testing for those with risk factors. In the UK, NICE recommends an oral glucose tolerance test at 24–28 weeks only for women with risk factors.Checked against:Glucose screening tests during pregnancy · MedlinePlus (NIH) (2026); Gestational diabetes · MedlinePlus (NIH) (2026)
Answer
B · At about 24–28 weeks of pregnancy
10.Lab values & electrolytes
Answer: B · Report it, monitor urine output and hold metformin until reviewed
Why this is the answer
A creatinine rise of 0.3 mg/dL or more within 48 hours meets the criteria for AKI, and contrast is a recognized risk factor, especially in CKD and diabetes. The nurse reports it, monitors fluid balance and holds metformin until kidney function is reviewed, as metformin can accumulate.Checked against:Acute Kidney Injury · StatPearls (NCBI Bookshelf) (2026); Abdominal CT scan · MedlinePlus (NIH) (2024); Acute kidney failure · MedlinePlus (NIH) (2026)
Answer
B · Report it, monitor urine output and hold metformin until reviewed
11.Arterial blood gas interpretation
Answer: PaCO₂ = 29 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·14 + 8 = 29 mmHg
range: 27–31 mmHg
Answer
PaCO₂ = 29 mmHg
12.Arterial blood gas interpretation
Answer: appropriate compensation
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·9 + 8 = 21.5 → 19.5–23.5 mmHg
Compare
measured: 22 mmHg → appropriate compensation
Answer
appropriate compensation
13.ECG rhythm strip interpretation
Answer: QTc = 0.431 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 11 × 0.04 = 0.44 s
RR = 26 × 0.04 = 1.04 s
Bazett’s formula
QTc = 0.44/√1.04 = 0.44/1.02 = 0.431 s
Answer
QTc = 0.431 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (431 ms)
14.ECG rhythm strip interpretation
Answer: atrial rate = 79 bpm
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Atrial rate
P–P = 19 small boxes = 0.76 s → 1500 ÷ 19 = 78.95 ≈ 79 per minute
Ventricular rate
6 QRS complexes in 6 s × 10 = 60 per minute
Answer
atrial rate = 79 bpm
Answer
atrial rate = 79 bpm
Second-degree type II: 4 P waves for every 3 QRS complexes, with a constant PR.
15.Prioritization & delegation
Answer: C · Stop or slow the infusion and inform the provider
Why this is the answer
Flushing of the upper body during vancomycin is usually an infusion reaction related to the rate. The nurse stops or slows the infusion, assesses for anaphylaxis and informs the provider.
Answer
C · Stop or slow the infusion and inform the provider
16.Prioritization & delegation
Answer: D · Extubated 2 days ago, stable on 2 L/min nasal oxygen, no vasoactive infusions
Why this is the answer
The extubated patient on low-flow oxygen with no vasoactive drugs is stable and improving. Recent intubation, rising vasopressor needs and an active bleed all need ICU-level care.
Answer
D · Extubated 2 days ago, stable on 2 L/min nasal oxygen, no vasoactive infusions