Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
Which statement about direct oral anticoagulants such as apixaban and rivaroxaban is correct?
AMissed doses do not matter because they act for weeks
BNo routine INR checks, but doses depend on kidney function
CTheir effect is reversed by giving vitamin K
DWeekly INR checks are needed, as with warfarin
2.Med-surg: cardiovascular & respiratoryHard
One hour after cardiac surgery, a mediastinal chest drain has drained 350 mL of bright red blood and the heart rate is rising. What should the nurse do?
AStrip the tubing hard every five minutes
BRecord the volume and continue hourly checks
CReport it to the surgical team at once
DClamp the drain to stop further blood loss
3.Med-surg: neuro, endocrine & renalMedium
Fifteen minutes after treatment with glucose tablets, a patient's glucose has risen from 3.2 to 5.1 mmol/L. Their next meal is in two hours. What should happen next?
ANo further action is needed until the next meal is served later
BGive the usual dose of rapid-acting insulin straight away
CGive another dose of glucose tablets to push it higher
DGive a longer-acting carbohydrate snack, such as a sandwich
4.Med-surg: neuro, endocrine & renalHard
Six weeks after a kidney transplant, a patient has a fever, tenderness over the graft, less urine and a rising creatinine. What is most likely?
AAcute rejection, needing urgent transplant team review
BDehydration that needs only more oral fluids and rest
CA side effect of sun exposure
DA normal finding as the kidney settles in
5.Med-surg: GI, perioperative & oncologyMedium
How is an uncomplicated sigmoid volvulus often first treated?
AHigh-dose laxatives taken by mouth
BA barium meal given by mouth to untwist the bowel slowly
CEating a large high-fibre meal
DDecompression with a flexible sigmoidoscope and flatus tube
6.Med-surg: GI, perioperative & oncologyHard
A patient with bone metastases is starting regular zoledronic acid. Which advice is important?
AStop drinking all fluids on the day of each infusion
BTake extra calcium only on the day of infusion
CHave a dental check and report jaw pain or loose teeth
DAvoid all physical activity for six months
7.Clinical nursingMedium
Which instruction is correct for taking weekly alendronic acid (alendronate)?
ATake it with a glass of milk at bedtime and then lie down straight away
BTake it with plain water on an empty stomach and stay upright for 30 minutes
CChew the tablet with breakfast and a cup of milky tea
DTake it with an antacid to protect the stomach
8.Clinical nursingHard
A patient on IV vancomycin develops flushing and an itchy red rash on the face and neck during a fast infusion. What is the most likely cause and response?
ALiver failure; stop all medicines permanently
BNormal response; increase the infusion rate
CInfusion-related reaction; stop or slow the infusion and inform the prescriber
DSunburn; apply cream and continue
9.Lab values & electrolytesMedium
A patient with central diabetes insipidus starts desmopressin. Which laboratory result is most important to monitor for an adverse effect?
ASerum glucose, which may rise very high
BSerum sodium, which may fall too low
CSerum potassium, which may rise too high
DSerum calcium, which may rise too high
10.Lab values & electrolytesHard
A young woman with frequent self-induced vomiting has swollen salivary glands. Which laboratory pattern is most likely?
AHigh calcium, high phosphate and high glucose
BHigh potassium, low bicarbonate and low amylase
CLow sodium, low bicarbonate and high lipase
DLow potassium, high bicarbonate and high amylase
11.Arterial blood gas interpretationMedium
A practice gas shows PaCO₂ 58 mmHg (7.7 kPa). Use the rule that in acute respiratory acidosis HCO₃⁻ rises by 1 mmol/L for every 10 mmHg that PaCO₂ is above 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
A practice gas shows a respiratory acidosis: pH 7.29, PaCO₂ 65 mmHg (8.7 kPa), HCO₃⁻ 30 mmol/L. Use the rules ‘HCO₃⁻ rises 1 mmol/L per 10 mmHg (acute) or 3.5 mmol/L per 10 mmHg (chronic)’ to classify it. Click your answer.
pH 7.29PaCO₂ 65 mmHg (8.7 kPa)HCO₃⁻ 30 mmol/L
1acute
2chronic
3acute on chronic
13.ECG rhythm strip interpretationMedium
Interpret this lead II rhythm strip. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1sinus bradycardia
2junctional rhythm
3atrial fibrillation
4first-degree AV block
14.ECG rhythm strip interpretationHard
Identify the rhythm on this lead II strip. Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1idioventricular rhythm
2atrial flutter, 2:1 conduction
3ventricular fibrillation
4torsades de pointes
15.Prioritization & delegationMedium
A patient’s urinary catheter has drained no urine for two hours, and the lower abdomen is swollen. What should the nurse do first?
AEncourage the patient to drink more water
BRemove the catheter and wait for the patient to void
CGive a prescribed diuretic straight away
DCheck the tubing for kinks or obstruction
16.Prioritization & delegationHard
A patient with known abdominal aortic aneurysm suddenly has severe back pain, a pulsing mass in the abdomen and a falling blood pressure. What should the nurse do?
AGive an oral analgesic and reassess the patient in about one hour
BPalpate the mass firmly to check its size and spread
CEncourage the patient to walk to ease the back pain
DCall for emergency help at once and prepare for urgent surgery
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: B · No routine INR checks, but doses depend on kidney function
Why this is the answer
DOACs have predictable effects, so routine coagulation monitoring is not required. Renal function, weight, age and interacting drugs guide dosing. Because the effect wears off within a day or two, missed doses matter. Vitamin K does not reverse them; specific reversal agents exist.
Answer
B · No routine INR checks, but doses depend on kidney function
2.Med-surg: cardiovascular & respiratory
Answer: C · Report it to the surgical team at once
Why this is the answer
Drainage of more than about 100–200 mL/h (or a sudden large volume of fresh blood), especially with tachycardia or hypotension, may indicate surgical bleeding and needs urgent review. Clamping could cause cardiac tamponade. A sudden stop in drainage with falling blood pressure can also signal tamponade.
Answer
C · Report it to the surgical team at once
3.Med-surg: neuro, endocrine & renal
Answer: D · Give a longer-acting carbohydrate snack, such as a sandwich
Why this is the answer
Once glucose is above 4 mmol/L, a longer-acting carbohydrate (or the next meal if it is due) prevents a recurrence. The cause of the hypoglycaemia should be identified and documented, and the treatment plan reviewed if episodes recur.
Answer
D · Give a longer-acting carbohydrate snack, such as a sandwich
4.Med-surg: neuro, endocrine & renal
Answer: A · Acute rejection, needing urgent transplant team review
Why this is the answer
Fever, graft tenderness, falling urine output and rising creatinine suggest acute rejection, although infection must also be ruled out. Early treatment, often with high-dose steroids, can save the graft, so the transplant team is contacted urgently.
Answer
A · Acute rejection, needing urgent transplant team review
5.Med-surg: GI, perioperative & oncology
Answer: D · Decompression with a flexible sigmoidoscope and flatus tube
Why this is the answer
Endoscopic decompression often untwists a sigmoid volvulus. Recurrence is common, so elective surgery may follow. Signs of ischaemia or perforation need emergency surgery.
Answer
D · Decompression with a flexible sigmoidoscope and flatus tube
6.Med-surg: GI, perioperative & oncology
Answer: C · Have a dental check and report jaw pain or loose teeth
Why this is the answer
Bisphosphonates can cause osteonecrosis of the jaw, especially after dental extractions. A dental check before starting, good oral hygiene and reporting jaw symptoms are advised. Kidney function and calcium are also monitored.
Answer
C · Have a dental check and report jaw pain or loose teeth
7.Clinical nursing
Answer: B · Take it with plain water on an empty stomach and stay upright for 30 minutes
Why this is the answer
Alendronic acid must be taken with plain water before food, and the patient must stay upright to reduce oesophageal irritation. Food, milk and antacids reduce absorption.
Answer
B · Take it with plain water on an empty stomach and stay upright for 30 minutes
8.Clinical nursing
Answer: C · Infusion-related reaction; stop or slow the infusion and inform the prescriber
Why this is the answer
Rapid vancomycin infusion can release histamine and cause flushing and rash ("vancomycin infusion reaction"). Slowing the rate usually prevents it, but anaphylaxis must be excluded.
Answer
C · Infusion-related reaction; stop or slow the infusion and inform the prescriber
9.Lab values & electrolytes
Answer: B · Serum sodium, which may fall too low
Why this is the answer
Desmopressin acts like ADH, so the kidneys retain water. If the patient drinks too much, water retention can cause hyponatremia, which may lead to confusion and seizures. Sodium, weight and fluid balance are monitored.
Answer
B · Serum sodium, which may fall too low
10.Lab values & electrolytes
Answer: D · Low potassium, high bicarbonate and high amylase
Why this is the answer
Repeated vomiting causes hypokalemia and metabolic alkalosis (high bicarbonate) from the loss of stomach acid. Enlarged salivary glands can raise salivary amylase. Hypokalemia can cause dangerous arrhythmias, so it is monitored and corrected.Checked against:Bulimia · MedlinePlus (NIH) (2026)
Answer
D · Low potassium, high bicarbonate and high amylase
11.Arterial blood gas interpretation
Answer: HCO₃⁻ = 25.8 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|58 − 40| = 18 mmHg → 1.8 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 + 1·1.8 = 25.8 mmol/L
Answer
HCO₃⁻ = 25.8 mmol/L
12.Arterial blood gas interpretation
Answer: acute on chronic
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected HCO₃⁻
acute: 24 + 1·2.5 = 26.5 mmol/L
chronic: 24 + 3.5·2.5 = 32.75 mmol/L
Compare
measured: 30 mmol/L → acute on chronic
Answer
acute on chronic
13.ECG rhythm strip interpretation
Answer: junctional rhythm
Rhythm criteria (lead II): sinus rhythm has an upright P wave before every QRS, a constant PR of 0.12–0.20 s and a narrow QRS: normal sinus rhythm at 60–100/min, sinus bradycardia below 60, sinus tachycardia above 100. Atrial fibrillation: no P waves, a fibrillatory baseline and an irregularly irregular R–R. Atrial flutter: sawtooth flutter waves at about 250–350/min with a fixed conduction ratio such as 2:1 or 4:1. First-degree AV block: sinus rhythm with a constant PR above 0.20 s. Junctional rhythm: narrow QRS at 40–60/min with absent or inverted P waves (PR below 0.12 s, or P after the QRS). A PVC is an early, wide (0.12 s or more), bizarre QRS without a P wave, with the T wave in the opposite direction and usually a full compensatory pause; in bigeminy every second beat is a PVC.
Five steps
1. Rate: R–R = 35 small boxes, 1500 ÷ 35 ≈ 43 per minute.
2. Rhythm: regular, every R–R is 1.40 s.
3. P waves: none visible.
4. PR interval: not measurable.
5. QRS: 0.10 s, narrow (below 0.12 s).
Interpretation
junctional rhythm
Answer
junctional rhythm
14.ECG rhythm strip interpretation
Answer: torsades de pointes
More ventricular rhythms: torsades de pointes is a polymorphic ventricular tachycardia, usually 150–250/min, in which the wide complexes change in height and twist around the baseline, pointing up for a few beats and then down. Textbooks link it to a prolonged QT interval, and magnesium sulfate is the drug resuscitation guidelines name for it. An idioventricular rhythm is a ventricular escape rhythm: regular, wide QRS (0.12 s or more), no P waves, at 20–40/min (an accelerated idioventricular rhythm runs at 40–100/min). Monomorphic VT has identical wide complexes at more than 100/min. VF is chaotic, without any repeating complex.
Five steps
1. Rate: very fast, the complexes are about 7 small boxes apart (about 214 per minute).
2. Rhythm: fast and roughly regular, but the height and direction of the complexes change in a repeating spindle pattern.
3. P waves: none identifiable.
4. PR interval: not measurable.
5. QRS: wide and polymorphic; the complexes twist around the baseline, pointing up for a few beats and then down.
Interpretation
torsades de pointes
Answer
torsades de pointes
Torsades de pointes is a polymorphic VT linked to a prolonged QT interval. This is identification practice only.
15.Prioritization & delegation
Answer: D · Check the tubing for kinks or obstruction
Why this is the answer
Sudden lack of drainage with a full bladder usually means a kinked or blocked catheter. The nurse checks the tubing and position first, then follows the policy for irrigation or replacement.
Answer
D · Check the tubing for kinks or obstruction
16.Prioritization & delegation
Answer: D · Call for emergency help at once and prepare for urgent surgery
Why this is the answer
Sudden severe back or abdominal pain with hypotension in a patient with an aneurysm suggests rupture, which is fatal without urgent surgery. The mass should not be palpated firmly.
Answer
D · Call for emergency help at once and prepare for urgent surgery