Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient uses a glyceryl trinitrate (nitroglycerin) patch for angina. Why is it usually removed for several hours each day?
AA nitrate-free interval prevents tolerance
BIt lowers the risk of a high potassium level
CThe skin needs a break to absorb a larger dose
DThe patch works only during the night
2.Med-surg: cardiovascular & respiratoryHard
A patient's chest drain tubing disconnects from the drainage unit. What should the nurse do first?
ARemove the drain from the chest and cover the site
BLeave it open to air until the doctor arrives to review it
CClamp the tube for several hours and recheck the patient later
DReconnect it, or put the tube end in sterile water, then assess
3.Med-surg: neuro, endocrine & renalMedium
Why is metformin usually withheld during acute kidney injury or around iodinated contrast in at-risk patients?
AIt blocks the contrast so the scan cannot be read
BIt causes severe hypoglycaemia when given together with contrast
CIt can accumulate and raise the risk of lactic acidosis
DIt causes hyperkalaemia when the kidneys are injured
4.Med-surg: neuro, endocrine & renalHard
A man who takes tamsulosin for BPH is listed for cataract surgery. Which statement is correct?
AIt should be swapped for oxybutynin the night before to protect the eye
BThe dose should be doubled before surgery to prevent urinary retention
CTamsulosin has no effects outside the urinary tract, so nothing changes
DThe eye surgeon must be told, as it can cause floppy iris during surgery
5.Med-surg: GI, perioperative & oncologyMedium
Which measures help prevent tumour lysis syndrome in high-risk patients?
AIV hydration with allopurinol or rasburicase
BStopping all IV and oral fluids during the chemotherapy
CFluid restriction with potassium tablets
DCalcium and phosphate supplements daily
6.Med-surg: GI, perioperative & oncologyHard
A patient with breast cancer becomes confused, thirsty and constipated, with polyuria. Which oncological emergency should be considered?
ASuperior vena cava obstruction
BHypoglycaemia
CHypercalcaemia of malignancy
DTumour lysis syndrome
7.Clinical nursingMedium
A patient with liver cirrhosis becomes confused and drowsy, with a flapping tremor of the hands. Which complication is likely?
AHepatic encephalopathy
BStroke
CAlcohol intoxication only
DHypoglycaemia caused by insulin
8.Clinical nursingHard
Which sign is often a late finding in hypovolaemic shock in a young, previously fit adult?
AA fall in blood pressure
BA rise in heart rate
CA slightly raised respiratory rate
DCool peripheries
9.Lab values & electrolytesMedium
A healthy woman at 28 weeks of pregnancy has a mildly lower hemoglobin than before pregnancy, with a normal MCV and ferritin. What is the most likely explanation?
AIron is being lost through the kidneys during the pregnancy
BPregnancy hormones stop the bone marrow from making red cells
CPlasma volume rises more than red cell mass, diluting the blood
DThe fetus is destroying the mother's red cells in the circulation
10.Lab values & electrolytesHard
A patient with jaundice and nausea has a positive IgM antibody to hepatitis A virus (IgM anti-HAV). What does this show?
AA current or recent hepatitis A infection
BPast hepatitis B infection that has cleared
CChronic hepatitis A lasting many years
DImmunity from hepatitis A vaccine long ago
11.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.15, PaCO₂ 21 mmHg (2.8 kPa) and HCO₃⁻ 7 mmol/L. The primary disorder is metabolic acidosis. How far is it compensated? Click your answer.
pH 7.15PaCO₂ 21 mmHg (2.8 kPa)HCO₃⁻ 7 mmol/L
1uncompensated
2partially compensated
3fully compensated
12.Arterial blood gas interpretationHard
A practice gas shows a metabolic alkalosis with HCO₃⁻ 46 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 46 mmol/L
PaCO₂ = mmHg
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
This lead II strip shows a conduction problem between the atria and the ventricles. Which rhythm is it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1second-degree AV block type I (Wenckebach)
2third-degree (complete) AV block
3junctional rhythm
4second-degree AV block type II
15.Prioritization & delegationMedium
A patient uses patient-controlled analgesia (PCA) after surgery. Which statement by a family member shows a need for further teaching?
A“The pump has limits set by the nurse so she cannot get too much at once.”
B“I will press the button for her while she is asleep so she stays comfortable.”
C“I will tell the nurse if she becomes very sleepy or hard to wake.”
D“Only she should press the button when she needs pain relief.”
16.Prioritization & delegationHard
A patient on airborne precautions for suspected tuberculosis must go to the radiology department. What should the patient wear during transport?
AA surgical mask
BNothing, if the trip is short
CA fit-tested N95 respirator
DGloves and a gown only
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: A · A nitrate-free interval prevents tolerance
Why this is the answer
Continuous nitrate use leads to tolerance within days. A daily nitrate-free period (often overnight, when angina is least likely) keeps the drug effective. Patients are taught to rotate patch sites.
Answer
A · A nitrate-free interval prevents tolerance
2.Med-surg: cardiovascular & respiratory
Answer: D · Reconnect it, or put the tube end in sterile water, then assess
Why this is the answer
A disconnected tube lets atmospheric air enter the pleural space. Reconnecting quickly, or submerging the tube end 2–3 cm in sterile water as a temporary seal, restores the one-way valve. Then assess for respiratory distress and inform the team. Prolonged clamping risks tension pneumothorax.
Answer
D · Reconnect it, or put the tube end in sterile water, then assess
3.Med-surg: neuro, endocrine & renal
Answer: C · It can accumulate and raise the risk of lactic acidosis
Why this is the answer
Metformin is excreted by the kidneys. In AKI, or when contrast could worsen kidney function, it may accumulate and increase the risk of lactic acidosis. It is withheld according to kidney function and local guidance and restarted when renal function is stable.
Answer
C · It can accumulate and raise the risk of lactic acidosis
4.Med-surg: neuro, endocrine & renal
Answer: D · The eye surgeon must be told, as it can cause floppy iris during surgery
Why this is the answer
Tamsulosin blocks alpha-1A receptors in the iris dilator muscle as well as in the prostate, which can cause intraoperative floppy iris syndrome during cataract surgery. The effect can persist after the drug is stopped, so the surgeon must know in advance to plan the operation. Whether to pause it is a decision for the team.
Answer
D · The eye surgeon must be told, as it can cause floppy iris during surgery
5.Med-surg: GI, perioperative & oncology
Answer: A · IV hydration with allopurinol or rasburicase
Why this is the answer
Prevention includes aggressive hydration to maintain high urine output, allopurinol (reduces uric acid production) or rasburicase (breaks down uric acid) and close monitoring of electrolytes, renal function and urine output.
Answer
A · IV hydration with allopurinol or rasburicase
6.Med-surg: GI, perioperative & oncology
Answer: C · Hypercalcaemia of malignancy
Why this is the answer
Hypercalcaemia of malignancy causes thirst, polyuria, dehydration, constipation, nausea, confusion and arrhythmias. Treatment is IV fluids followed by a bisphosphonate, with monitoring of calcium and renal function. Tumour lysis causes low calcium.
Answer
C · Hypercalcaemia of malignancy
7.Clinical nursing
Answer: A · Hepatic encephalopathy
Why this is the answer
Hepatic encephalopathy causes confusion and asterixis. Lactulose is commonly used to reduce ammonia absorption and treat precipitants such as infection or bleeding.
Answer
A · Hepatic encephalopathy
8.Clinical nursing
Answer: A · A fall in blood pressure
Why this is the answer
Young adults compensate for blood loss with tachycardia and vasoconstriction, so blood pressure may stay normal until a large volume is lost. Hypotension is therefore a late and serious sign.
Answer
A · A fall in blood pressure
9.Lab values & electrolytes
Answer: C · Plasma volume rises more than red cell mass, diluting the blood
Why this is the answer
In pregnancy, plasma volume increases by more than red cell mass, so the hemoglobin falls slightly (physiologic or dilutional anemia). Iron deficiency is still common in pregnancy and is checked with the MCV and ferritin.Checked against:Anemia · StatPearls (NCBI Bookshelf) (2026)
Answer
C · Plasma volume rises more than red cell mass, diluting the blood
10.Lab values & electrolytes
Answer: A · A current or recent hepatitis A infection
Why this is the answer
IgM antibodies appear early, so IgM anti-HAV indicates acute hepatitis A. IgG anti-HAV alone shows past infection or vaccination and lifelong immunity. Hepatitis A does not become chronic and spreads by the fecal-oral route, so hand hygiene is essential.Checked against:Hepatitis A · MedlinePlus (NIH) (2025)
Answer
A · A current or recent hepatitis A infection
11.Arterial blood gas interpretation
Answer: partially compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.15: acidaemia (below 7.35)
PaCO₂ 21 mmHg: low (35–45)
HCO₃⁻ 7 mmol/L: low (22–26)
Compensation
Clinically, also check the expected compensation: Winter’s formula expects PaCO₂ 16.5–20.5 mmHg, so the measured 21 mmHg points to an additional respiratory acidosis (a mixed disorder). The answer above is the ROME exam classification.
partially compensated
Answer
partially compensated
12.Arterial blood gas interpretation
Answer: PaCO₂ = 53.2 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·46 + 21 = 53.2 mmHg
Answer
PaCO₂ = 53.2 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
13.ECG rhythm strip interpretation
Answer: QTc = 0.402 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 9 × 0.04 = 0.36 s
RR = 20 × 0.04 = 0.80 s
Bazett’s formula
QTc = 0.36/√0.80 = 0.36/0.8944 = 0.402 s
Answer
QTc = 0.402 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (402 ms)
14.ECG rhythm strip interpretation
Answer: third-degree (complete) AV block
AV blocks: march out the P waves and check which ones are followed by a QRS. First-degree: every P conducted, PR constant and above 0.20 s. Second-degree type I (Mobitz I, Wenckebach): the PR lengthens from beat to beat until one P wave is not conducted, then the cycle starts again (group beating). Second-degree type II (Mobitz II): the PR of the conducted beats stays constant, and P waves are suddenly not conducted; the QRS is often wide. Third-degree (complete) block: P waves and QRS complexes are each regular but independent, the PR varies at random and the atrial rate is faster than the escape rate (junctional 40–60/min with a narrow QRS, ventricular 20–40/min with a wide QRS). A 2:1 block cannot be called type I or type II from one strip.
Five steps
1. Rate: R–R = 51 small boxes, 1500 ÷ 51 ≈ 29 per minute.
2. Rhythm: R–R regular (2.04 s) and P–P regular (0.76 s), but the two are independent.
3. P waves: upright and regular at 79 per minute, but not linked to the QRS complexes; some hide in a QRS or a T wave.
4. PR interval: varies from beat to beat; there is no fixed relation.
5. QRS: 0.14 s, wide (0.12 s or more).
Interpretation
third-degree (complete) AV block
Answer
third-degree (complete) AV block
Type II and third-degree blocks are the ones that can suddenly progress, so textbooks rank them as more serious than type I.
15.Prioritization & delegation
Answer: B · “I will press the button for her while she is asleep so she stays comfortable.”
Why this is the answer
PCA is safe because a sleepy patient cannot press the button. If someone else presses it, the patient can receive too much opioid and develop respiratory depression.
Answer
B · “I will press the button for her while she is asleep so she stays comfortable.”
16.Prioritization & delegation
Answer: A · A surgical mask
Why this is the answer
A patient with an airborne infection wears a surgical mask outside the isolation room to contain respiratory particles. Staff caring for the patient wear fit-tested respirators, and the receiving department is told in advance.