Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
ECG rhythm strip interpretation
Paper (25 mm/s, 10 mm/mV)
1 small box = 0.04 s, 1 large box = 0.20 s, 10 mm = 1 mV
Heart rate, regular rhythm
300 ÷ large boxes = 1500 ÷ small boxes = 60 ÷ RR (s)
Heart rate, irregular rhythm
QRS complexes in 6 s × 10
Normal PR interval
0.12–0.20 s
Normal QRS duration
< 0.12 s
QTc (Bazett)
QT/√RR
QTc (Fridericia)
QT/∛RR
QTc (Framingham)
QT + 154·(1 − RR)
Sinus rates
bradycardia < 60, normal 60–100, tachycardia > 100 /min
Escape rates
junctional 40–60, ventricular 20–40 /min
Fast rhythms
SVT 150–250 /min (narrow), VT > 100 /min (wide)
Method
Rate: for a regular rhythm divide 300 by the large boxes or 1500 by the small boxes between two R waves; for an irregular rhythm count the QRS complexes in 6 seconds and multiply by 10.
Rhythm: compare the R–R intervals. Equal is regular; a repeating pattern is regularly irregular; no pattern at all is irregularly irregular.
P waves: is there an upright P wave in lead II before every QRS, all alike? Look for fibrillatory or sawtooth waves, inverted P waves and P waves without a QRS.
PR interval: from the start of P to the start of the QRS, normally 0.12–0.20 s and constant. Watch whether it lengthens, stays fixed before a dropped beat, or varies at random.
QRS duration: below 0.12 s is narrow; 0.12 s or more is wide. Then name the rhythm, and for the QT use QTc = QT/√RR (Bazett) with times in seconds.
Prioritization & delegation
Method
Ask what will harm the patient soonest if nothing is done.
Apply ABC (C-A-B in cardiac arrest), then Maslow: physiological needs before safety, safety before psychological needs.
Compare the options: acute before chronic, unstable before stable, unexpected before expected, systemic before local, and check each finding against the patient’s baseline.
Assess before you act unless it is an emergency; then choose the step the others depend on.
For delegation, check the five rights: task, circumstance, person, directions and supervision. Assessment, teaching and evaluation stay with the RN.
2Practice problems
1.Med-surg: cardiovascular & respiratoryMedium
A patient with asthma uses their reliever inhaler more than three times a week. What does this suggest?
AAsthma is well controlled with the current plan
BThe preventer inhaler is no longer needed
CAsthma control is poor and treatment needs review
DThe reliever no longer works and should be stopped
2.Med-surg: cardiovascular & respiratoryHard
A patient with pneumonia has a temperature of 39 °C, pain and a sinus tachycardia of 122/min. BP is normal. What is the best way to manage the heart rate?
AArrange urgent electrical cardioversion to restore a normal rate
BTreat the fever, pain and possible dehydration, then reassess
CGive IV adenosine
DGive a beta-blocker to bring the heart rate below 100/min
3.Med-surg: neuro, endocrine & renalMedium
Which nursing action helps prevent a rise in intracranial pressure?
AEncouraging hard coughing every hour
BDoing all care and suctioning in one long session
CLying the patient flat with the hips bent sharply
DPreventing constipation and spacing out care
4.Med-surg: neuro, endocrine & renalHard
A haemodialysis patient with a tunnelled central venous catheter develops fever and rigors soon after dialysis starts. What should the nurse suspect and do?
ACatheter-related bloodstream infection; stop, take cultures and escalate
BDialysis disequilibrium; speed up dialysis to finish sooner
CAir embolism; tilt the patient head-up and continue
DNormal reaction to dialysis; continue and give paracetamol only
5.Med-surg: GI, perioperative & oncologyMedium
During the first infusion of a monoclonal antibody such as rituximab, which problem is most important to watch for?
ASudden hair loss during the infusion
BAn infusion reaction, such as fever, rigors or breathlessness
CA rise in platelet count above normal
DSevere constipation within the first hour of starting the infusion
6.Med-surg: GI, perioperative & oncologyHard
During preoperative assessment, a patient says their brother had a "very high fever" during an anaesthetic. What is the most important action?
AReassure the patient that fevers after anaesthesia are always harmless
BInform the anaesthetist, as malignant hyperthermia may run in the family
CRecord it as a family allergy to paracetamol
DGive paracetamol before surgery to prevent fever
7.Clinical nursingMedium
Why are patients with atrial fibrillation often given anticoagulants?
ATo convert the rhythm back to normal
BTo lower the blood pressure
CTo slow the heart rate directly and prevent palpitations
DTo reduce the risk of stroke from clots in the atria
8.Clinical nursingHard
Why is hypokalaemia particularly dangerous in a patient taking digoxin?
ALow potassium makes digoxin work too slowly
BLow potassium increases the risk of digoxin toxicity
CDigoxin raises potassium to dangerous levels when it is already low
DLow potassium stops digoxin from being absorbed
9.Lab values & electrolytesMedium
An older adult with chronic kidney disease takes glyburide (glibenclamide, a sulfonylurea) and has repeated low glucose readings. Why is this a concern?
AThe drug causes high potassium that lowers the glucose
BThe drug and its metabolites build up and cause long lows
CThe drug makes the glucose meter read falsely low
DThe drug stops working entirely when the kidneys fail
10.Lab values & electrolytesHard
A patient with severe hypertriglyceridemia has a measured sodium of 128 mEq/L, but a measured serum osmolality is normal, and the patient has no symptoms. What is the most likely explanation?
AHyponatremia caused by drinking far too much water
BTrue hyponatremia from SIADH that needs fluid restriction
CHyponatremia caused by severe hyperglycemia in diabetes
DPseudohyponatremia, an artifact caused by very high lipids
11.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 12 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 12 mmol/L
PaCO₂ = mmHg
12.Arterial blood gas interpretationHard
Practice values: Na⁺ 139, Cl⁻ 92 and HCO₃⁻ 9 mmol/L. Calculate the delta ratio (AG − 12)/(24 − HCO₃⁻), using AG = Na⁺ − (Cl⁻ + HCO₃⁻). Give two decimals.
Na⁺ 139 mmol/LCl⁻ 92 mmol/LHCO₃⁻ 9 mmol/L
delta ratio =
13.ECG rhythm strip interpretationMedium
Measure the QT interval and the R–R interval on this regular lead II strip, then calculate the rate-corrected QTc with Bazett’s formula QTc = QT/√RR (both in seconds). Give the answer in seconds to three decimals.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
QTc = s
14.ECG rhythm strip interpretationHard
A patient without a palpable pulse has this organised rhythm on the monitor (pulseless electrical activity). Which treatment do adult resuscitation guidelines name for it? Click your answer.
lead II, 25 mm/s, 10 mm/mV1 small box = 0.04 s, 1 large box = 0.20 sstrip length 6 s
1CPR (non-shockable rhythm)
2synchronised cardioversion
3immediate defibrillation
4transcutaneous pacing
15.Prioritization & delegationMedium
A patient at 35 weeks of pregnancy with high blood pressure calls the clinic. Which symptom needs urgent assessment?
AMild ankle swelling at the end of the day
BNeeding to pass urine more often
CBackache after a long walk
DA severe headache with blurred vision
16.Prioritization & delegationHard
Two weeks after birth, a mother says she hears voices telling her the baby is evil. What is the priority?
ALeave her alone with the baby to bond
BAdvise more sleep and book a routine follow-up visit for next month
CReassure her that this is normal “baby blues”
DKeep the mother and baby safe and arrange urgent psychiatric care
3Solutions
1.Med-surg: cardiovascular & respiratory
Answer: C · Asthma control is poor and treatment needs review
Why this is the answer
Needing a reliever often, waking at night with symptoms or limiting activity indicates poorly controlled asthma. Inhaler technique, adherence and triggers should be checked and the regular preventer treatment stepped up.
Answer
C · Asthma control is poor and treatment needs review
2.Med-surg: cardiovascular & respiratory
Answer: B · Treat the fever, pain and possible dehydration, then reassess
Why this is the answer
Sinus tachycardia is usually a physiological response to fever, pain, hypovolaemia, anxiety, hypoxia or sepsis. Treating the cause (antipyretics, analgesia, fluids, oxygen if needed) is appropriate, while watching for sepsis. Rate-slowing drugs can be harmful by masking compensation.
Answer
B · Treat the fever, pain and possible dehydration, then reassess
3.Med-surg: neuro, endocrine & renal
Answer: D · Preventing constipation and spacing out care
Why this is the answer
Straining, coughing, prolonged suctioning, hip flexion, pain and agitation raise ICP. Stool softeners, adequate analgesia and spacing care so that ICP can recover between activities help keep it down.
Answer
D · Preventing constipation and spacing out care
4.Med-surg: neuro, endocrine & renal
Answer: A · Catheter-related bloodstream infection; stop, take cultures and escalate
Why this is the answer
Fever and rigors when dialysis starts through a central catheter strongly suggest a catheter-related bloodstream infection. Dialysis is stopped or adjusted per protocol, blood cultures are taken (from the catheter and peripherally), the team is informed and IV antibiotics are started as prescribed. The exit site is inspected.
Answer
A · Catheter-related bloodstream infection; stop, take cultures and escalate
5.Med-surg: GI, perioperative & oncology
Answer: B · An infusion reaction, such as fever, rigors or breathlessness
Why this is the answer
Infusion-related reactions are most common with the first dose. Premedication, a slow starting rate, close monitoring and readiness to stop the infusion and treat anaphylaxis are standard.
Answer
B · An infusion reaction, such as fever, rigors or breathlessness
6.Med-surg: GI, perioperative & oncology
Answer: B · Inform the anaesthetist, as malignant hyperthermia may run in the family
Why this is the answer
Malignant hyperthermia susceptibility is inherited. The anaesthetist plans a trigger-free anaesthetic, avoiding volatile agents and suxamethonium, and the family may be referred for testing.
Answer
B · Inform the anaesthetist, as malignant hyperthermia may run in the family
7.Clinical nursing
Answer: D · To reduce the risk of stroke from clots in the atria
Why this is the answer
In AF the atria do not contract effectively, so blood can pool and clot, especially in the left atrial appendage. A clot can travel to the brain, so anticoagulation reduces stroke risk.
Answer
D · To reduce the risk of stroke from clots in the atria
8.Clinical nursing
Answer: B · Low potassium increases the risk of digoxin toxicity
Why this is the answer
Digoxin binds to the sodium–potassium ATPase at the site potassium normally uses. When potassium is low, digoxin binds more, raising the risk of toxicity and arrhythmias.
Answer
B · Low potassium increases the risk of digoxin toxicity
9.Lab values & electrolytes
Answer: B · The drug and its metabolites build up and cause long lows
Why this is the answer
Glyburide and its active metabolites are cleared by the kidneys, so they accumulate in CKD and can cause severe, prolonged hypoglycemia. Older adults are at greater risk. The prescriber is informed, and a different drug is usually chosen.
Answer
B · The drug and its metabolites build up and cause long lows
10.Lab values & electrolytes
Answer: D · Pseudohyponatremia, an artifact caused by very high lipids
Why this is the answer
Very high lipids or proteins take up part of the plasma volume, so some laboratory methods report a falsely low sodium. The osmolality and the sodium measured by direct methods are normal. Treating this "hyponatremia" would be harmful.
Answer
D · Pseudohyponatremia, an artifact caused by very high lipids
11.Arterial blood gas interpretation
Answer: PaCO₂ = 26 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·12 + 8 = 26 mmHg
range: 24–28 mmHg
Answer
PaCO₂ = 26 mmHg
12.Arterial blood gas interpretation
Answer: delta ratio = 1.733
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 139 − (92 + 9) = 38
Delta ratio
(38 − 12)/(24 − 9) = 26/15 = 1.733
Answer
delta ratio = 1.733
Between 1 and 2: a pure high anion gap acidosis.
13.ECG rhythm strip interpretation
Answer: QTc = 0.436 s
QT and QTc: the QT interval runs from the start of the QRS complex to the end of the T wave. It shortens as the heart rate rises, so it is corrected for rate with the R–R interval in seconds: Bazett QTc = QT/√RR and Fridericia QTc = QT/∛RR. Bazett is the formula most textbooks use; it over-corrects at fast rates, where Fridericia is preferred. Limits differ between references: a QTc above about 0.45 s in men or 0.46 s in women is usually called prolonged, and above 0.50 s markedly prolonged.
Measure
QT = 9.5 × 0.04 = 0.38 s
RR = 19 × 0.04 = 0.76 s
Bazett’s formula
QTc = 0.38/√0.76 = 0.38/0.8718 = 0.436 s
Answer
QTc = 0.436 s
Within the usual limits (about 0.45 s for men, 0.46 s for women). (436 ms)
14.ECG rhythm strip interpretation
Answer: CPR (non-shockable rhythm)
Pulseless electrical activity (PEA): PEA cannot be seen on a strip. The monitor shows organised electrical activity (a rhythm other than VF, VT or asystole) but the patient has no palpable pulse, so it is recognised by checking the patient. In adult resuscitation guidelines PEA and asystole are the non-shockable cardiac arrest rhythms: high-quality CPR, epinephrine as soon as possible and a search for reversible causes (the Hs and Ts, such as hypovolaemia, hypoxia, tension pneumothorax and cardiac tamponade). VF and pulseless VT are the shockable rhythms.
What the strip shows
1. Rate: R–R = 29 small boxes, 1500 ÷ 29 ≈ 52 per minute.
2. Rhythm: regular, every R–R is 1.16 s.
3. P waves: inverted, just after each QRS.
4. PR interval: not measurable.
5. QRS: 0.08 s, narrow (below 0.12 s).
junctional rhythm
What the patient shows
no pulse despite organised electrical activity: pulseless electrical activity (PEA), a non-shockable cardiac arrest rhythm
Answer
CPR (non-shockable rhythm)
Answer
CPR (non-shockable rhythm)
PEA is recognised at the bedside, never from the strip alone. This is exam practice, not clinical guidance.
15.Prioritization & delegation
Answer: D · A severe headache with blurred vision
Why this is the answer
A severe headache and visual changes can be signs of severe pre-eclampsia and a risk of eclampsia. Mild ankle swelling, backache and frequent urination are common in late pregnancy.
Answer
D · A severe headache with blurred vision
16.Prioritization & delegation
Answer: D · Keep the mother and baby safe and arrange urgent psychiatric care
Why this is the answer
Hallucinations and delusions after birth suggest postpartum psychosis, a psychiatric emergency with risk to mother and baby. Safety and urgent specialist care are the priorities.
Answer
D · Keep the mother and baby safe and arrange urgent psychiatric care