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1Formulas and methods
Pediatric & critical-care dosing
Daily dose
mg/day = mg/kg/day × weight (kg)
Doses per day
number = 24 h / dosing interval (h)
Pounds to kilograms
kg = lb / 2.2
Infusion concentration
units/mL = units in bag / bag volume
Pump rate
mL/h = dose per hour / concentration
Titrated drip
mL/h = mcg/kg/min × kg × 60 / (mcg/mL)
Dose from pump rate
mcg/kg/min = mL/h × (mcg/mL) / (60 × kg)
Units
1 mg = 1000 mcg
Dosage calculations
Dose from strength
volume = dose / strength
Weight-based dose
dose = mg/kg × body weight
Tablets
number = dose / tablet strength
Units
1 g = 1000 mg, 1 mg = 1000 mcg
Method
Convert the ordered dose and the stock strength to the same unit.
Use desired over have times quantity: (D/H) × Q.
For weight-based doses, multiply by the weight in kg first, then divide the daily dose by the number of doses.
Estimate first and check that the answer is reasonable.
IV infusion rates
Pump rate
mL/h = volume (mL)/time (h)
Drip rate
drops/min = volume (mL) × drop factor / time (min)
Infusion time
time (h) = volume (mL)/rate (mL/h)
Method
Pump rate in mL/h: volume divided by time in hours.
Drip rate in drops/min: volume × drop factor divided by time in minutes.
For time remaining: volume left divided by the rate.
Round as the question or the equipment requires.
2Practice problems
1.Pediatric & critical-care dosingMedium
Practice exercise (made-up values, not clinical guidance). An infusion contains 250 units of regular insulin in 250 mL. The order is 0.05 units/kg/h for a patient who weighs 90 kg. Find the pump rate R in mL/h. Round to one decimal place.
250 units/250 mL0.05 units/kg/h90 kg
R = mL/h
2.Pediatric & critical-care dosingHard
Practice exercise (made-up values, not clinical guidance). A bag contains dobutamine 500 mg in 250 mL. The order is 10 mcg/kg/min for a patient who weighs 91 kg. At what rate R do you set the pump, in mL/h? Round to one decimal place.
500 mg/250 mL10 mcg/kg/min91 kg
R = mL/h
3.Dosage calculationsMedium
A child weighing 34 kg is prescribed 10 mg/kg of a drug. The stock solution contains 50 mg/mL. Draw up the dose: what volume V do you give?
34 kg10 mg/kg50 mg/mL
V = mL
4.Dosage calculationsHard
A patient weighs 143 lb. The prescription is 0.5 mg/kg as a single dose, and the stock contains 10 mg in 1 mL. Using 1 kg = 2.2 lb, what volume V do you give? Round to one decimal place.
143 lb0.5 mg/kg10 mg/1 mL1 kg = 2.2 lb
V = mL
5.IV infusion ratesMedium
Infuse 1500 mL over 5 hours with a giving set of 20 gtt/mL. Find the drip rate R in drops per minute.
1500 mL5 h20 gtt/mL
R = gtt/min
6.IV infusion ratesHard
A drip runs at 28 gtt/min through a set of 60 gtt/mL. There are 600 mL left in the bag. How many hours t until it is empty? Round to one decimal place.
28 gtt/min60 gtt/mL600 mL
t = h
3Solutions
1.Pediatric & critical-care dosing
Answer: R = 4.5 mL/h
Heparin and insulin infusions: concentration = units in the bag/bag volume (units/mL). Pump rate (mL/h) = units per hour/concentration, and units per hour = mL/h × concentration. For a weight-based order, units/h = units/kg/h × weight first. A bolus volume = units needed/vial strength. The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.
Units per hour
0.05·90 = 4.5 units/h
Concentration
250/250 = 1 units/mL
Pump rate
R = 4.5/1 = 4.5 mL/h
Answer
R = 4.5 mL/h
2.Pediatric & critical-care dosing
Answer: R = 27.3 mL/h
Titrated drips: first find the concentration in mcg/mL (mg × 1000/mL). For a weight-based order, mcg/min = mcg/kg/min × weight. Then mL/h = mcg/min × 60/concentration. Working backwards, mcg/kg/min = mL/h × concentration/(60 × weight). The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.
Concentration
500 mg = 500 000 mcg
500 000/250 = 2000 mcg/mL
Dose per minute and per hour
10·91 = 910 mcg/min
910·60 = 54600 mcg/h
Pump rate
R = 54600/2000 = 27.3 mL/h
Answer
R = 27.3 mL/h
3.Dosage calculations
Answer: V = 6.8 mL
Drawing up a dose: volume = (prescribed dose/stock strength) × stock volume. Convert to the same units first, then check that the volume fits the syringe and lands on one of its graduations.
Dose from body weight
D = 10·34 = 340 mg
Volume
V = 340/50 = 6.8 mL
On the syringe
On this 10 mL syringe every small line is 0.2 mL.
Answer
V = 6.8 mL
4.Dosage calculations
Answer: V = 3.3 mL
Dose calculation: the amount to give equals what is prescribed divided by what you have, times the quantity it comes in: amount = (desired dose/stock strength) × stock volume. Always keep the units the same (convert g to mg, mg to mcg first) and check that the answer is sensible.
Weight in kg
143/2.2 = 65 kg
Dose
0.5·65 = 32.5 mg
Volume
V = (32.5/10)·1 = 3.25 ≈ 3.3 mL
Answer
V = 3.3 mL
5.IV infusion rates
Answer: R = 100 gtt/min
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.
Time in minutes
5·60 = 300 min
Drip rate
R = 1500·20/300 = 100 gtt/min
Answer
R = 100 gtt/min
6.IV infusion rates
Answer: t = 21.4 h
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.