Pediatric and Critical-Care Dosing: cram pack

Formula sheets, the key method steps for every topic and 6 practice problems, with full solutions at the back.

New problemsBack to the course

In the print window, choose “Save as PDF” to keep a copy on your device.

1Formulas and methods

Pediatric & critical-care dosing

Daily dose
mg/day = mg/kg/day × weight (kg)
Doses per day
number = 24 h / dosing interval (h)
Pounds to kilograms
kg = lb / 2.2
Infusion concentration
units/mL = units in bag / bag volume
Pump rate
mL/h = dose per hour / concentration
Titrated drip
mL/h = mcg/kg/min × kg × 60 / (mcg/mL)
Dose from pump rate
mcg/kg/min = mL/h × (mcg/mL) / (60 × kg)
Units
1 mg = 1000 mcg

Dosage calculations

Dose from strength
volume = dose / strength
Weight-based dose
dose = mg/kg × body weight
Tablets
number = dose / tablet strength
Units
1 g = 1000 mg, 1 mg = 1000 mcg

Method

  1. Convert the ordered dose and the stock strength to the same unit.
  2. Use desired over have times quantity: (D/H) × Q.
  3. For weight-based doses, multiply by the weight in kg first, then divide the daily dose by the number of doses.
  4. Estimate first and check that the answer is reasonable.

IV infusion rates

Pump rate
mL/h = volume (mL)/time (h)
Drip rate
drops/min = volume (mL) × drop factor / time (min)
Infusion time
time (h) = volume (mL)/rate (mL/h)

Method

  1. Pump rate in mL/h: volume divided by time in hours.
  2. Drip rate in drops/min: volume × drop factor divided by time in minutes.
  3. For time remaining: volume left divided by the rate.
  4. Round as the question or the equipment requires.

2Practice problems

1.Pediatric & critical-care dosingMedium
250 units250 mLregular insulin? mL/h90 kg0.05 units/kg/h

Practice exercise (made-up values, not clinical guidance). An infusion contains 250 units of regular insulin in 250 mL. The order is 0.05 units/kg/h for a patient who weighs 90 kg. Find the pump rate R in mL/h. Round to one decimal place.

250 units/250 mL0.05 units/kg/h90 kg
R = mL/h
2.Pediatric & critical-care dosingHard
500 mg250 mLdobutamine? mL/h91 kg10 mcg/kg/min

Practice exercise (made-up values, not clinical guidance). A bag contains dobutamine 500 mg in 250 mL. The order is 10 mcg/kg/min for a patient who weighs 91 kg. At what rate R do you set the pump, in mL/h? Round to one decimal place.

500 mg/250 mL10 mcg/kg/min91 kg
R = mL/h
3.Dosage calculationsMedium
024681010 mL

A child weighing 34 kg is prescribed 10 mg/kg of a drug. The stock solution contains 50 mg/mL. Draw up the dose: what volume V do you give?

34 kg10 mg/kg50 mg/mL
V = mL
4.Dosage calculationsHard
10 mg/1 mLV = ? mL

A patient weighs 143 lb. The prescription is 0.5 mg/kg as a single dose, and the stock contains 10 mg in 1 mL. Using 1 kg = 2.2 lb, what volume V do you give? Round to one decimal place.

143 lb0.5 mg/kg10 mg/1 mL1 kg = 2.2 lb
V = mL
5.IV infusion ratesMedium
1500 mL20 gtt/mL5 h? gtt/min

Infuse 1500 mL over 5 hours with a giving set of 20 gtt/mL. Find the drip rate R in drops per minute.

1500 mL5 h20 gtt/mL
R = gtt/min
6.IV infusion ratesHard
600 mL60 gtt/mL28 gtt/mint = ? h

A drip runs at 28 gtt/min through a set of 60 gtt/mL. There are 600 mL left in the bag. How many hours t until it is empty? Round to one decimal place.

28 gtt/min60 gtt/mL600 mL
t = h

3Solutions

1.Pediatric & critical-care dosing

Answer: R = 4.5 mL/h

Heparin and insulin infusions: concentration = units in the bag/bag volume (units/mL). Pump rate (mL/h) = units per hour/concentration, and units per hour = mL/h × concentration. For a weight-based order, units/h = units/kg/h × weight first. A bolus volume = units needed/vial strength. The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.

Units per hour

0.05·90 = 4.5 units/h

Concentration

250/250 = 1 units/mL

Pump rate

R = 4.5/1 = 4.5 mL/h

Answer

R = 4.5 mL/h
2.Pediatric & critical-care dosing

Answer: R = 27.3 mL/h

Titrated drips: first find the concentration in mcg/mL (mg × 1000/mL). For a weight-based order, mcg/min = mcg/kg/min × weight. Then mL/h = mcg/min × 60/concentration. Working backwards, mcg/kg/min = mL/h × concentration/(60 × weight). The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.

Concentration

500 mg = 500 000 mcg
500 000/250 = 2000 mcg/mL

Dose per minute and per hour

10·91 = 910 mcg/min
910·60 = 54600 mcg/h

Pump rate

R = 54600/2000 = 27.3 mL/h

Answer

R = 27.3 mL/h
3.Dosage calculations

Answer: V = 6.8 mL

Drawing up a dose: volume = (prescribed dose/stock strength) × stock volume. Convert to the same units first, then check that the volume fits the syringe and lands on one of its graduations.

Dose from body weight

D = 10·34 = 340 mg

Volume

V = 340/50 = 6.8 mL

On the syringe

On this 10 mL syringe every small line is 0.2 mL.

Answer

V = 6.8 mL
4.Dosage calculations

Answer: V = 3.3 mL

Dose calculation: the amount to give equals what is prescribed divided by what you have, times the quantity it comes in: amount = (desired dose/stock strength) × stock volume. Always keep the units the same (convert g to mg, mg to mcg first) and check that the answer is sensible.

Weight in kg

143/2.2 = 65 kg

Dose

0.5·65 = 32.5 mg

Volume

V = (32.5/10)·1 = 3.25 ≈ 3.3 mL

Answer

V = 3.3 mL
5.IV infusion rates

Answer: R = 100 gtt/min

Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.

Time in minutes

5·60 = 300 min

Drip rate

R = 1500·20/300 = 100 gtt/min

Answer

R = 100 gtt/min
6.IV infusion rates

Answer: t = 21.4 h

Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.

Rate in mL/h

28·60/60 = 28 mL/h

Time left

t = 600/28 = 21.43 ≈ 21.4 h

Answer

t = 21.4 h

ExamProblems · examproblems.com/courses/pediatric-and-critical-care-dosing