Pediatric and Critical-Care Dosing: cram pack

Formula sheets, the key method steps for every topic and 6 practice problems, with full solutions at the back.

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1Formulas and methods

Pediatric & critical-care dosing

Daily dose
mg/day = mg/kg/day × weight (kg)
Doses per day
number = 24 h / dosing interval (h)
Pounds to kilograms
kg = lb / 2.2
Infusion concentration
units/mL = units in bag / bag volume
Pump rate
mL/h = dose per hour / concentration
Titrated drip
mL/h = mcg/kg/min × kg × 60 / (mcg/mL)
Dose from pump rate
mcg/kg/min = mL/h × (mcg/mL) / (60 × kg)
Units
1 mg = 1000 mcg

Dosage calculations

Dose from strength
volume = dose / strength
Weight-based dose
dose = mg/kg × body weight
Tablets
number = dose / tablet strength
Units
1 g = 1000 mg, 1 mg = 1000 mcg

Method

  1. Convert the ordered dose and the stock strength to the same unit.
  2. Use desired over have times quantity: (D/H) × Q.
  3. For weight-based doses, multiply by the weight in kg first, then divide the daily dose by the number of doses.
  4. Estimate first and check that the answer is reasonable.

IV infusion rates

Pump rate
mL/h = volume (mL)/time (h)
Drip rate
drops/min = volume (mL) × drop factor / time (min)
Infusion time
time (h) = volume (mL)/rate (mL/h)

Method

  1. Pump rate in mL/h: volume divided by time in hours.
  2. Drip rate in drops/min: volume × drop factor divided by time in minutes.
  3. For time remaining: volume left divided by the rate.
  4. Round as the question or the equipment requires.

2Practice problems

1.Pediatric & critical-care dosingMedium
12 500 units250 mLheparin? mL/h75 kg15 units/kg/h

Practice exercise (made-up values, not clinical guidance). A bag contains 12 500 units of heparin in 250 mL. The order is 15 units/kg/h for a patient who weighs 75 kg. At what rate R do you set the pump, in mL/h? Round to one decimal place.

12 500 units/250 mL15 units/kg/h75 kg
R = mL/h
2.Pediatric & critical-care dosingHard
25 mg250 mLnitroglycerin? mL/h76 kg5 mcg/min

Practice exercise (made-up values, not clinical guidance). A patient who weighs 76 kg has an order for nitroglycerin at 5 mcg/min. The bag contains 25 mg in 250 mL. Find the pump rate R in mL/h. Round to one decimal place.

25 mg/250 mL5 mcg/min76 kg
R = mL/h
3.Dosage calculationsMedium
024681010 mL

A child weighing 20 kg is prescribed 2 mg/kg of a drug. The stock solution contains 10 mg/mL. Draw up the dose: what volume V do you give?

20 kg2 mg/kg10 mg/mL
V = mL
4.Dosage calculationsHard
00.10.20.30.40.50.60.70.80.911 mL

The prescription is 220 units of a drug that comes as 1000 units/mL. Draw up the dose in the 1 mL syringe: what volume V do you give?

220 units1000 units/mL
V = mL
5.IV infusion ratesMedium
15 gtt/mL60 mL/h? gtt/min

An infusion is ordered at 60 mL/h, but no pump is available. It runs by gravity through a giving set of 15 gtt/mL. Find the drip rate R in drops per minute.

60 mL/h15 gtt/mL
R = gtt/min
6.IV infusion ratesHard
200 mL60 gtt/mL25 gtt/mint = ? h

A drip runs at 25 gtt/min through a set of 60 gtt/mL. There are 200 mL left in the bag. How many hours t until it is empty?

25 gtt/min60 gtt/mL200 mL
t = h

3Solutions

1.Pediatric & critical-care dosing

Answer: R = 22.5 mL/h

Heparin and insulin infusions: concentration = units in the bag/bag volume (units/mL). Pump rate (mL/h) = units per hour/concentration, and units per hour = mL/h × concentration. For a weight-based order, units/h = units/kg/h × weight first. A bolus volume = units needed/vial strength. The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.

Units per hour

15·75 = 1 125 units/h

Concentration

12 500/250 = 50 units/mL

Pump rate

R = 1125/50 = 22.5 mL/h

Answer

R = 22.5 mL/h
2.Pediatric & critical-care dosing

Answer: R = 3 mL/h

Titrated drips: first find the concentration in mcg/mL (mg × 1000/mL). For a weight-based order, mcg/min = mcg/kg/min × weight. Then mL/h = mcg/min × 60/concentration. Working backwards, mcg/kg/min = mL/h × concentration/(60 × weight). The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.

Concentration

25 000/250 = 100 mcg/mL

Dose per hour

The order is per minute for the whole patient, so the weight is not needed.

5·60 = 300 mcg/h

Pump rate

R = 300/100 = 3 mL/h

Answer

R = 3 mL/h
3.Dosage calculations

Answer: V = 4 mL

Drawing up a dose: volume = (prescribed dose/stock strength) × stock volume. Convert to the same units first, then check that the volume fits the syringe and lands on one of its graduations.

Dose from body weight

D = 2·20 = 40 mg

Volume

V = 40/10 = 4 mL

On the syringe

On this 10 mL syringe every small line is 0.2 mL.

Answer

V = 4 mL
4.Dosage calculations

Answer: V = 0.22 mL

Drawing up a dose: volume = (prescribed dose/stock strength) × stock volume. Convert to the same units first, then check that the volume fits the syringe and lands on one of its graduations.

Volume

V = 220/1000 = 0.22 mL

On the syringe

On this 1 mL syringe every small line is 0.01 mL.

Answer

V = 0.22 mL
5.IV infusion rates

Answer: R = 15 gtt/min

Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.

Millilitres per minute

60/60 = 1 mL/min

Drip rate

R = 1·15 = 15 gtt/min

Answer

R = 15 gtt/min
6.IV infusion rates

Answer: t = 8 h

Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.

Rate in mL/h

25·60/60 = 25 mL/h

Time left

t = 200/25 = 8 h

Answer

t = 8 h

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