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1Formulas and methods
Pediatric & critical-care dosing
Daily dose
mg/day = mg/kg/day × weight (kg)
Doses per day
number = 24 h / dosing interval (h)
Pounds to kilograms
kg = lb / 2.2
Infusion concentration
units/mL = units in bag / bag volume
Pump rate
mL/h = dose per hour / concentration
Titrated drip
mL/h = mcg/kg/min × kg × 60 / (mcg/mL)
Dose from pump rate
mcg/kg/min = mL/h × (mcg/mL) / (60 × kg)
Units
1 mg = 1000 mcg
Dosage calculations
Dose from strength
volume = dose / strength
Weight-based dose
dose = mg/kg × body weight
Tablets
number = dose / tablet strength
Units
1 g = 1000 mg, 1 mg = 1000 mcg
Method
Convert the ordered dose and the stock strength to the same unit.
Use desired over have times quantity: (D/H) × Q.
For weight-based doses, multiply by the weight in kg first, then divide the daily dose by the number of doses.
Estimate first and check that the answer is reasonable.
IV infusion rates
Pump rate
mL/h = volume (mL)/time (h)
Drip rate
drops/min = volume (mL) × drop factor / time (min)
Infusion time
time (h) = volume (mL)/rate (mL/h)
Method
Pump rate in mL/h: volume divided by time in hours.
Drip rate in drops/min: volume × drop factor divided by time in minutes.
For time remaining: volume left divided by the rate.
Round as the question or the equipment requires.
2Practice problems
1.Pediatric & critical-care dosingMedium
Practice exercise (made-up values, not clinical guidance). An infusion contains 100 units of regular insulin in 100 mL. The order is 0.05 units/kg/h for a patient who weighs 86 kg. Find the pump rate R in mL/h. Round to one decimal place.
100 units/100 mL0.05 units/kg/h86 kg
R = mL/h
2.Pediatric & critical-care dosingHard
Practice exercise (made-up values, not clinical guidance). A patient who weighs 61 kg has an order for norepinephrine at 16 mcg/min. The bag contains 8 mg in 250 mL. Find the pump rate R in mL/h. Round to one decimal place.
8 mg/250 mL16 mcg/min61 kg
R = mL/h
3.Dosage calculationsMedium
A patient weighs 70 kg. The prescribed dose is 30 mg/kg per day, given in 2 equal doses. How many milligrams D are given per dose?
70 kg30 mg/kg/day2× per day
D = mg
4.Dosage calculationsHard
A child weighing 18 kg is prescribed 20 mg/kg per dose of an oral suspension that contains 250 mg in 5 mL. What volume V do you give?
18 kg20 mg/kg250 mg/5 mL
V = mL
5.IV infusion ratesMedium
500 mL was ordered over 6 hours. After 3 hours you find that 270 mL is still in the bag, and the order must still finish on time. To what rate R in mL/h must the pump be reset?
500 mL / 6 hafter 3 h: 270 mL
R = mL/h
6.IV infusion ratesHard
A drip runs at 28 gtt/min through a set of 15 gtt/mL. There are 200 mL left in the bag. How many hours t until it is empty? Round to one decimal place.
28 gtt/min15 gtt/mL200 mL
t = h
3Solutions
1.Pediatric & critical-care dosing
Answer: R = 4.3 mL/h
Heparin and insulin infusions: concentration = units in the bag/bag volume (units/mL). Pump rate (mL/h) = units per hour/concentration, and units per hour = mL/h × concentration. For a weight-based order, units/h = units/kg/h × weight first. A bolus volume = units needed/vial strength. The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.
Units per hour
0.05·86 = 4.3 units/h
Concentration
100/100 = 1 units/mL
Pump rate
R = 4.3/1 = 4.3 mL/h
Answer
R = 4.3 mL/h
2.Pediatric & critical-care dosing
Answer: R = 30 mL/h
Titrated drips: first find the concentration in mcg/mL (mg × 1000/mL). For a weight-based order, mcg/min = mcg/kg/min × weight. Then mL/h = mcg/min × 60/concentration. Working backwards, mcg/kg/min = mL/h × concentration/(60 × weight). The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.
Concentration
8 000/250 = 32 mcg/mL
Dose per hour
The order is per minute for the whole patient, so the weight is not needed.
16·60 = 960 mcg/h
Pump rate
R = 960/32 = 30 mL/h
Answer
R = 30 mL/h
3.Dosage calculations
Answer: D = 1050 mg
Dose calculation: the amount to give equals what is prescribed divided by what you have, times the quantity it comes in: amount = (desired dose/stock strength) × stock volume. Always keep the units the same (convert g to mg, mg to mcg first) and check that the answer is sensible.
Total per day
30·70 = 2100 mg
Per dose
D = 2100/2 = 1050 mg
Answer
D = 1050 mg
4.Dosage calculations
Answer: V = 7.2 mL
Dose calculation: the amount to give equals what is prescribed divided by what you have, times the quantity it comes in: amount = (desired dose/stock strength) × stock volume. Always keep the units the same (convert g to mg, mg to mcg first) and check that the answer is sensible.
Dose from weight
20·18 = 360 mg
Volume
V = (360/250)·5 = 7.2 mL
Answer
V = 7.2 mL
5.IV infusion rates
Answer: R = 90 mL/h
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.
Original rate
500/6 = 83.33 mL/h
New rate
R = 270/3 = 90 mL/h
Answer
R = 90 mL/h
Many hospitals allow such an adjustment up to 25% without a new order; check local policy.
6.IV infusion rates
Answer: t = 1.8 h
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.