Pediatric and Critical-Care Dosing: cram pack

Formula sheets, the key method steps for every topic and 6 practice problems, with full solutions at the back.

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1Formulas and methods

Pediatric & critical-care dosing

Daily dose
mg/day = mg/kg/day × weight (kg)
Doses per day
number = 24 h / dosing interval (h)
Pounds to kilograms
kg = lb / 2.2
Infusion concentration
units/mL = units in bag / bag volume
Pump rate
mL/h = dose per hour / concentration
Titrated drip
mL/h = mcg/kg/min × kg × 60 / (mcg/mL)
Dose from pump rate
mcg/kg/min = mL/h × (mcg/mL) / (60 × kg)
Units
1 mg = 1000 mcg

Dosage calculations

Dose from strength
volume = dose / strength
Weight-based dose
dose = mg/kg × body weight
Tablets
number = dose / tablet strength
Units
1 g = 1000 mg, 1 mg = 1000 mcg

Method

  1. Convert the ordered dose and the stock strength to the same unit.
  2. Use desired over have times quantity: (D/H) × Q.
  3. For weight-based doses, multiply by the weight in kg first, then divide the daily dose by the number of doses.
  4. Estimate first and check that the answer is reasonable.

IV infusion rates

Pump rate
mL/h = volume (mL)/time (h)
Drip rate
drops/min = volume (mL) × drop factor / time (min)
Infusion time
time (h) = volume (mL)/rate (mL/h)

Method

  1. Pump rate in mL/h: volume divided by time in hours.
  2. Drip rate in drops/min: volume × drop factor divided by time in minutes.
  3. For time remaining: volume left divided by the rate.
  4. Round as the question or the equipment requires.

2Practice problems

1.Pediatric & critical-care dosingMedium
250 units250 mLregular insulin12 mL/h? units/h

Practice exercise (made-up values, not clinical guidance). An infusion of 250 units of regular insulin in 250 mL runs at 12 mL/h. How many units per hour D does the patient receive?

250 units/250 mL12 mL/h
D = units/h
2.Pediatric & critical-care dosingHard
8 mg250 mLnorepinephrine? mL/h83 kg12 mcg/min

Practice exercise (made-up values, not clinical guidance). A patient who weighs 83 kg has an order for norepinephrine at 12 mcg/min. The bag contains 8 mg in 250 mL. Find the pump rate R in mL/h. Round to one decimal place.

8 mg/250 mL12 mcg/min83 kg
R = mL/h
3.Dosage calculationsMedium
024681010 mL

A child weighing 8 kg is prescribed 20 mg/kg of a drug. The stock solution contains 25 mg/mL. Draw up the dose: what volume V do you give?

8 kg20 mg/kg25 mg/mL
V = mL
4.Dosage calculationsHard
25k units250 mL? mL/h500 units/h

An infusion contains 25000 units of a drug in 250 mL. The prescription is 500 units per hour. At what rate R do you set the pump, in mL/h?

25000 units/250 mL500 units/h
R = mL/h
5.IV infusion ratesMedium
1500 mL20 gtt/mL12 h? gtt/min

Infuse 1500 mL over 12 hours with a giving set of 20 gtt/mL. Find the drip rate R in drops per minute. Round to the nearest whole number.

1500 mL12 h20 gtt/mL
R = gtt/min
6.IV infusion ratesHard
570 mLleft? mL/h3 h left

1000 mL was ordered over 6 hours. After 3 hours you find that 570 mL is still in the bag, and the order must still finish on time. By what percentage Δ must the original pump rate be increased?

1000 mL / 6 hafter 3 h: 570 mL
Δ = %

3Solutions

1.Pediatric & critical-care dosing

Answer: D = 12 units/h

Heparin and insulin infusions: concentration = units in the bag/bag volume (units/mL). Pump rate (mL/h) = units per hour/concentration, and units per hour = mL/h × concentration. For a weight-based order, units/h = units/kg/h × weight first. A bolus volume = units needed/vial strength. The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.

Concentration

250/250 = 1 units/mL

Units per hour

D = 12·1 = 12 units/h

Answer

D = 12 units/h
2.Pediatric & critical-care dosing

Answer: R = 22.5 mL/h

Titrated drips: first find the concentration in mcg/mL (mg × 1000/mL). For a weight-based order, mcg/min = mcg/kg/min × weight. Then mL/h = mcg/min × 60/concentration. Working backwards, mcg/kg/min = mL/h × concentration/(60 × weight). The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.

Concentration

8 000/250 = 32 mcg/mL

Dose per hour

The order is per minute for the whole patient, so the weight is not needed.

12·60 = 720 mcg/h

Pump rate

R = 720/32 = 22.5 mL/h

Answer

R = 22.5 mL/h
3.Dosage calculations

Answer: V = 6.4 mL

Drawing up a dose: volume = (prescribed dose/stock strength) × stock volume. Convert to the same units first, then check that the volume fits the syringe and lands on one of its graduations.

Dose from body weight

D = 20·8 = 160 mg

Volume

V = 160/25 = 6.4 mL

On the syringe

On this 10 mL syringe every small line is 0.2 mL.

Answer

V = 6.4 mL
4.Dosage calculations

Answer: R = 5 mL/h

Dose calculation: the amount to give equals what is prescribed divided by what you have, times the quantity it comes in: amount = (desired dose/stock strength) × stock volume. Always keep the units the same (convert g to mg, mg to mcg first) and check that the answer is sensible.

Concentration

25000/250 = 100 units/mL

Pump rate

R = 500/100 = 5 mL/h

Answer

R = 5 mL/h
5.IV infusion rates

Answer: R = 42 gtt/min

Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.

Time in minutes

12·60 = 720 min

Drip rate

R = 1500·20/720 = 41.67 ≈ 42 gtt/min

Answer

R = 42 gtt/min

At the bedside you round to the nearest whole drop: 42 gtt/min.

6.IV infusion rates

Answer: Δ = 14 %

Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.

Original rate

1000/6 = 166.7 mL/h

New rate

R = 570/3 = 190 mL/h

Percentage change

Δ = (190 − 166.7)/166.7·100% = 14%

Answer

Δ = 14%

Many hospitals allow such an adjustment up to 25% without a new order; check local policy.

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