In the print window, choose “Save as PDF” to keep a copy on your device.
1Formulas and methods
Pediatric & critical-care dosing
Daily dose
mg/day = mg/kg/day × weight (kg)
Doses per day
number = 24 h / dosing interval (h)
Pounds to kilograms
kg = lb / 2.2
Infusion concentration
units/mL = units in bag / bag volume
Pump rate
mL/h = dose per hour / concentration
Titrated drip
mL/h = mcg/kg/min × kg × 60 / (mcg/mL)
Dose from pump rate
mcg/kg/min = mL/h × (mcg/mL) / (60 × kg)
Units
1 mg = 1000 mcg
Dosage calculations
Dose from strength
volume = dose / strength
Weight-based dose
dose = mg/kg × body weight
Tablets
number = dose / tablet strength
Units
1 g = 1000 mg, 1 mg = 1000 mcg
Method
Convert the ordered dose and the stock strength to the same unit.
Use desired over have times quantity: (D/H) × Q.
For weight-based doses, multiply by the weight in kg first, then divide the daily dose by the number of doses.
Estimate first and check that the answer is reasonable.
IV infusion rates
Pump rate
mL/h = volume (mL)/time (h)
Drip rate
drops/min = volume (mL) × drop factor / time (min)
Infusion time
time (h) = volume (mL)/rate (mL/h)
Method
Pump rate in mL/h: volume divided by time in hours.
Drip rate in drops/min: volume × drop factor divided by time in minutes.
For time remaining: volume left divided by the rate.
Round as the question or the equipment requires.
2Practice problems
1.Pediatric & critical-care dosingMedium
Practice exercise (made-up values, not clinical guidance). A bag contains 12 500 units of heparin in 250 mL. The order is 20 units/kg/h for a patient who weighs 97 kg. At what rate R do you set the pump, in mL/h? Round to one decimal place.
12 500 units/250 mL20 units/kg/h97 kg
R = mL/h
2.Pediatric & critical-care dosingHard
Practice exercise (made-up values, not clinical guidance). A bag contains dobutamine 250 mg in 250 mL. The order is 2.5 mcg/kg/min for a patient who weighs 59 kg. At what rate R do you set the pump, in mL/h? Round to one decimal place.
250 mg/250 mL2.5 mcg/kg/min59 kg
R = mL/h
3.Dosage calculationsMedium
A child weighing 28 kg is prescribed 2.5 mg/kg of a drug. The stock solution contains 50 mg/mL. Draw up the dose: what volume V do you give?
28 kg2.5 mg/kg50 mg/mL
V = mL
4.Dosage calculationsHard
The prescription is 780 units of a drug that comes as 1000 units/mL. Draw up the dose in the 1 mL syringe: what volume V do you give?
780 units1000 units/mL
V = mL
5.IV infusion ratesMedium
1500 mL was ordered over 6 hours. After 3 hours you find that 810 mL is still in the bag, and the order must still finish on time. To what rate R in mL/h must the pump be reset?
1500 mL / 6 hafter 3 h: 810 mL
R = mL/h
6.IV infusion ratesHard
A drip runs at 50 gtt/min through a set of 15 gtt/mL. There are 200 mL left in the bag. How many hours t until it is empty?
50 gtt/min15 gtt/mL200 mL
t = h
3Solutions
1.Pediatric & critical-care dosing
Answer: R = 38.8 mL/h
Heparin and insulin infusions: concentration = units in the bag/bag volume (units/mL). Pump rate (mL/h) = units per hour/concentration, and units per hour = mL/h × concentration. For a weight-based order, units/h = units/kg/h × weight first. A bolus volume = units needed/vial strength. The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.
Units per hour
20·97 = 1 940 units/h
Concentration
12 500/250 = 50 units/mL
Pump rate
R = 1940/50 = 38.8 mL/h
Answer
R = 38.8 mL/h
2.Pediatric & critical-care dosing
Answer: R = 8.9 mL/h
Titrated drips: first find the concentration in mcg/mL (mg × 1000/mL). For a weight-based order, mcg/min = mcg/kg/min × weight. Then mL/h = mcg/min × 60/concentration. Working backwards, mcg/kg/min = mL/h × concentration/(60 × weight). The numbers are for practice only; at the bedside always follow local protocols and have high-risk doses double-checked.
Concentration
250 mg = 250 000 mcg
250 000/250 = 1000 mcg/mL
Dose per minute and per hour
2.5·59 = 147.5 mcg/min
147.5·60 = 8850 mcg/h
Pump rate
R = 8850/1000 = 8.85 ≈ 8.9 mL/h
Answer
R = 8.9 mL/h
3.Dosage calculations
Answer: V = 1.4 mL
Drawing up a dose: volume = (prescribed dose/stock strength) × stock volume. Convert to the same units first, then check that the volume fits the syringe and lands on one of its graduations.
Dose from body weight
D = 2.5·28 = 70 mg
Volume
V = 70/50 = 1.4 mL
On the syringe
On this 10 mL syringe every small line is 0.2 mL.
Answer
V = 1.4 mL
4.Dosage calculations
Answer: V = 0.78 mL
Drawing up a dose: volume = (prescribed dose/stock strength) × stock volume. Convert to the same units first, then check that the volume fits the syringe and lands on one of its graduations.
Volume
V = 780/1000 = 0.78 mL
On the syringe
On this 1 mL syringe every small line is 0.01 mL.
Answer
V = 0.78 mL
5.IV infusion rates
Answer: R = 270 mL/h
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.
Original rate
1500/6 = 250 mL/h
New rate
R = 810/3 = 270 mL/h
Answer
R = 270 mL/h
Many hospitals allow such an adjustment up to 25% without a new order; check local policy.
6.IV infusion rates
Answer: t = 1 h
Infusion rates: a pump is set in mL/h = volume/time in hours. A gravity drip is counted in drops per minute: gtt/min = volume (mL) × drop factor (gtt/mL)/time (min). The drop factor is printed on the tubing package: macrodrip sets deliver 10, 15 or 20 gtt/mL (blood sets often 10 gtt/mL in the US, 15 in the UK) and microdrip sets 60 gtt/mL. Always use the drop factor the question or package gives.