Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A patient has Hb 113 g/L, SaO₂ 98% and PaO₂ 109 mmHg (14.5 kPa). Find the arterial oxygen content CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg) in mL O₂/dL.
Hb 113 g/LSaO₂ 98%PaO₂ 109 mmHg (14.5 kPa)
CaO₂ = mL/dL
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A transfer will take 75 minutes. The size E cylinder (factor 0.28 L/psi) reads 1550 psi. Keeping a safe residual of 200 psi, what is the highest whole-number flow Q in L/min that lasts the whole transfer?
75 min1550 psif = 0.28 L/psi200 psi
Q = L/min
3.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.23, PaCO₂ 42 mmHg (5.6 kPa) and HCO₃⁻ 17 mmol/L. The primary disorder is metabolic acidosis. How far is it compensated? Click your answer.
pH 7.23PaCO₂ 42 mmHg (5.6 kPa)HCO₃⁻ 17 mmol/L
1uncompensated
2partially compensated
3fully compensated
4.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 21% oxygen shows PaO₂ 79 mmHg (10.5 kPa) and PaCO₂ 41 mmHg (5.5 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Practice exercise (made-up values, not clinical guidance). A practice patient after a head injury opens the eyes when spoken to, talks in sentences but is confused and shows as the best motor response: obeys commands. Work out the GCS and classify the head injury by it. Click your answer.
1mild
2moderate
3severe
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). An adult weighs 59 kg and is 165 cm tall. Calculate the BMI and click the WHO weight category.
59 kg165 cm
1underweight
2healthy weight
3overweight
4obesity class I
5obesity class II
6obesity class III
7.Med-surg: cardiovascular & respiratoryMedium
Why is a non-selective beta-blocker such as propranolol usually avoided in a patient with asthma?
AIt raises the heart rate sharply during an acute asthma attack
BIt can cause bronchospasm by blocking beta-2 receptors
CIt thickens airway mucus by drying the airways
DIt makes inhaled corticosteroids work too strongly
8.Med-surg: cardiovascular & respiratoryHard
Why is humidification used with high-flow oxygen?
AHumidified gas carries more oxygen per litre than dry gas
BHumidification stops oxygen toxicity from developing
CDry gas at high flow dries the airway and thickens secretions
DWater vapour filters bacteria from the oxygen supply
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: CaO₂ = 15.17 mL/dL
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Hb in g/dL
113 g/L = 11.3 g/dL
Bound oxygen
1.34·11.3·0.98 = 14.84 mL/dL
Dissolved oxygen
0.003·109 = 0.327 mL/dL
Oxygen content
CaO₂ = 14.84 + 0.327 = 15.17 mL/dL
Answer
CaO₂ = 15.17 mL/dL
2.Oxygen therapy & respiratory calculations
Answer: Q = 5 L/min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(1550 − 200)·0.28 = 378 L
Highest flow
378/75 = 5.04 L/min → Q = 5 L/min
Answer
Q = 5 L/min
3.Arterial blood gas interpretation
Answer: uncompensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.23: acidaemia (below 7.35)
PaCO₂ 42 mmHg: normal (35–45)
HCO₃⁻ 17 mmol/L: low (22–26)
Compensation
Clinically, also check the expected compensation: Winter’s formula expects PaCO₂ 31.5–35.5 mmHg, so the measured 42 mmHg points to an additional respiratory acidosis (a mixed disorder). The answer above is the ROME exam classification.
uncompensated
Answer
uncompensated
4.Arterial blood gas interpretation
Answer: A–a gradient = 19.48 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Glasgow Coma Scale: add the best response in three areas. Eye opening E: 4 spontaneous, 3 to sound or speech, 2 to pressure, 1 none. Verbal V: 5 oriented, 4 confused, 3 inappropriate words, 2 incomprehensible sounds, 1 none. Motor M: 6 obeys commands, 5 localises, 4 normal flexion (withdraws), 3 abnormal flexion, 2 extension, 1 none. The total runs from 3 to 15. After a head injury, 13–15 is usually called mild, 9–12 moderate and 3–8 severe.
Score each area
E: opens the eyes when spoken to → 3
V: talks in sentences but is confused → 4
M: obeys commands → 6
Add
GCS = 3 + 4 + 6 = 13
Severity
GCS 13 → mild
Answer
mild
6.Clinical assessment scores
Answer: healthy weight
Body mass index: BMI = weight (kg)/height (m)², with the height converted to metres first. With pounds and inches, BMI = 703 × weight (lb)/height (in)². WHO adult categories: below 18.5 underweight, 18.5–24.9 healthy weight, 25.0–29.9 overweight, 30.0–34.9 obesity class I, 35.0–39.9 obesity class II and 40 or more obesity class III.
BMI
BMI = 59/1.65² = 21.67
Category
healthy weight
Answer
healthy weight
7.Med-surg: cardiovascular & respiratory
Answer: B · It can cause bronchospasm by blocking beta-2 receptors
Why this is the answer
Beta-2 receptors in the airways mediate bronchodilation. Blocking them can trigger severe bronchospasm in asthma and also blunts the effect of salbutamol. Cardioselective beta-1 blockers are safer but still used with caution.
Answer
B · It can cause bronchospasm by blocking beta-2 receptors
8.Med-surg: cardiovascular & respiratory
Answer: C · Dry gas at high flow dries the airway and thickens secretions
Why this is the answer
High-flow dry gas overwhelms the nose's ability to humidify, causing dry mucosa, thick secretions and discomfort. Warmed, humidified high-flow systems improve tolerance and help clear secretions.
Answer
C · Dry gas at high flow dries the airway and thickens secretions