Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A ventilated patient who meets the other Berlin criteria for ARDS has PaO₂ 87 mmHg (11.6 kPa) on 100% oxygen with a PEEP of 12 cmH₂O. Calculate the P/F ratio and click the ARDS severity.
PaO₂ 87 mmHg (11.6 kPa)FiO₂ 100%PEEP 12 cmH₂O
1above 300: no ARDS grade
2mild
3moderate
4severe
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A patient with acute hypoxaemia and bilateral opacities, not explained by heart failure, has PaO₂ 14.3 kPa on 45% oxygen with a PEEP of 8 cmH₂O. Grade the ARDS severity with the Berlin definition. Click your answer.
PaO₂ 14.3 kPaFiO₂ 45%PEEP 8 cmH₂O
1above 300: no ARDS grade
2mild
3moderate
4severe
5not gradable: PEEP below 5
3.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.53, PaCO₂ 25 mmHg (3.3 kPa) and HCO₃⁻ 20 mmol/L. The primary disorder is respiratory alkalosis. How far is it compensated? Click your answer.
pH 7.53PaCO₂ 25 mmHg (3.3 kPa)HCO₃⁻ 20 mmol/L
1uncompensated
2partially compensated
3fully compensated
4.Arterial blood gas interpretationHard
A practice gas shows a respiratory acidosis: pH 7.29, PaCO₂ 84 mmHg (11.2 kPa), HCO₃⁻ 39 mmol/L. Use the rules ‘HCO₃⁻ rises 1 mmol/L per 10 mmHg (acute) or 3.5 mmol/L per 10 mmHg (chronic)’ to classify it. Click your answer.
pH 7.29PaCO₂ 84 mmHg (11.2 kPa)HCO₃⁻ 39 mmol/L
1acute
2chronic
3acute on chronic
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice patient after a head injury opens the eyes only to pressure (a painful stimulus), makes no sounds and shows as the best motor response: extension of the arms and legs (abnormal extension). Work out the GCS and classify the head injury by it. Click your answer.
1mild
2moderate
3severe
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). Use the NEWS2 chart (SpO₂ scale 1) for these observations: respiration rate 18/min, SpO₂ 94% on supplemental oxygen, blood pressure 142/86 mmHg, pulse 130/min, newly confused, temperature 38.4 °C. Which clinical risk group does the patient fall into? Click it.
RR 18SpO₂ 94%O₂SBP 142HR 130CT 38.4 °C
1low
2low–medium
3medium
4high
7.Med-surg: cardiovascular & respiratoryMedium
What is the main difference between CPAP and bilevel NIV (often called BiPAP)?
ACPAP is given only through a tracheostomy
BBilevel NIV gives oxygen only, without any positive airway pressure
CCPAP is mainly used to lower a raised PaCO₂ in COPD exacerbations
DBilevel NIV adds a higher inspiratory pressure, helping remove CO₂
8.Med-surg: cardiovascular & respiratoryHard
Two adults with cystic fibrosis are admitted to the same ward. What is the correct infection-control plan?
ANurse them in separate single rooms and keep them apart
BPut them in the same bay so they can support each other
CLet them share physiotherapy sessions and equipment
DUse standard precautions only, as CF is not infectious
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: severe
P/F ratio and ARDS (Berlin definition): P/F = PaO₂ (mmHg)/FiO₂ (as a fraction). With PEEP or CPAP of at least 5 cmH₂O, ARDS is graded mild for 200 < P/F ≤ 300, moderate for 100 < P/F ≤ 200 and severe for P/F ≤ 100 mmHg. The other Berlin criteria (onset within a week, bilateral opacities, not fully explained by heart failure) must also be met. PaO₂ in kPa × 7.5 gives mmHg. The ROX index (SpO₂/FiO₂)/respiratory rate is used to follow patients on high-flow nasal oxygen.
P/F ratio
P/F = 87/1 = 87 mmHg
Berlin severity
severe
Answer
severe
2.Oxygen therapy & respiratory calculations
Answer: mild
P/F ratio and ARDS (Berlin definition): P/F = PaO₂ (mmHg)/FiO₂ (as a fraction). With PEEP or CPAP of at least 5 cmH₂O, ARDS is graded mild for 200 < P/F ≤ 300, moderate for 100 < P/F ≤ 200 and severe for P/F ≤ 100 mmHg. The other Berlin criteria (onset within a week, bilateral opacities, not fully explained by heart failure) must also be met. PaO₂ in kPa × 7.5 gives mmHg. The ROX index (SpO₂/FiO₂)/respiratory rate is used to follow patients on high-flow nasal oxygen.
PEEP
PEEP 8 ≥ 5 cmH₂O
PaO₂ in mmHg
14.3·7.5 = 107.3 mmHg
P/F ratio
P/F = 107.3/0.45 = 238.3 mmHg
Berlin severity
mild
Answer
mild
3.Arterial blood gas interpretation
Answer: partially compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.53: alkalaemia (above 7.45)
PaCO₂ 25 mmHg: low (35–45)
HCO₃⁻ 20 mmol/L: low (22–26)
Compensation
partially compensated
Answer
partially compensated
4.Arterial blood gas interpretation
Answer: chronic
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected HCO₃⁻
acute: 24 + 1·4.4 = 28.4 mmol/L
chronic: 24 + 3.5·4.4 = 39.4 mmol/L
Compare
measured: 39 mmol/L → chronic
Answer
chronic
5.Clinical assessment scores
Answer: severe
Glasgow Coma Scale: add the best response in three areas. Eye opening E: 4 spontaneous, 3 to sound or speech, 2 to pressure, 1 none. Verbal V: 5 oriented, 4 confused, 3 inappropriate words, 2 incomprehensible sounds, 1 none. Motor M: 6 obeys commands, 5 localises, 4 normal flexion (withdraws), 3 abnormal flexion, 2 extension, 1 none. The total runs from 3 to 15. After a head injury, 13–15 is usually called mild, 9–12 moderate and 3–8 severe.
Score each area
E: opens the eyes only to pressure (a painful stimulus) → 2
V: makes no sounds → 1
M: extension of the arms and legs (abnormal extension) → 2
Add
GCS = 2 + 1 + 2 = 5
Severity
GCS 5 → severe
Answer
severe
6.Clinical assessment scores
Answer: high
NEWS2 (National Early Warning Score 2, Royal College of Physicians 2017): score each of the seven parameters with the chart (respiration rate, SpO₂ on scale 1, air or supplemental oxygen, systolic blood pressure, pulse, consciousness on the ACVPU scale and temperature) and add the scores. Clinical risk: 0–4 low; a score of 3 in any single parameter low–medium; 5–6 medium; 7 or more high. A total of 5 or more needs an urgent response.
Score each parameter
RR 18/min → 0
SpO₂ 94% → 1
on oxygen → 2
SBP 142 mmHg → 0
HR 130/min → 2
newly confused (C) → 3
T 38.4 °C → 1
Total and red scores
NEWS2 = 0 + 1 + 2 + 0 + 2 + 3 + 1 = 9
At least one parameter scores 3.
Risk group
high
Answer
high
A total of 5 or more calls for an urgent clinical response.
7.Med-surg: cardiovascular & respiratory
Answer: D · Bilevel NIV adds a higher inspiratory pressure, helping remove CO₂
Why this is the answer
CPAP gives one continuous pressure that splints the airways and alveoli open, improving oxygenation (for example in pulmonary oedema or OSA). Bilevel NIV adds a higher inspiratory pressure that supports ventilation, so it is used for hypercapnic respiratory failure such as COPD exacerbations.
Answer
D · Bilevel NIV adds a higher inspiratory pressure, helping remove CO₂
8.Med-surg: cardiovascular & respiratory
Answer: A · Nurse them in separate single rooms and keep them apart
Why this is the answer
People with CF are colonised with organisms such as Pseudomonas aeruginosa and Burkholderia cepacia complex that can pass between patients and worsen outcomes. They are cared for in single rooms and kept apart, without sharing equipment or sessions.
Answer
A · Nurse them in separate single rooms and keep them apart