Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A size H oxygen cylinder (factor 3.14 L/psi) reads 1800 psi and runs at 5 L/min. Keeping a safe residual of 200 psi, how many minutes t will it last? Round down to a whole minute.
1800 psif = 3.14 L/psi5 L/min200 psi
t = min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A ventilated man is 183 cm tall and weighs 117 kg. Lung-protective ventilation is set at 6 mL per kg of predicted body weight. Using PBW = 50 + 0.91 × (height cm − 152.4) kg, find the tidal volume VT to the nearest mL.
183 cm117 kg6 mL/kg
VT = mL
3.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.49, PaCO₂ 41 mmHg (5.5 kPa) and HCO₃⁻ 30 mmol/L. The primary disorder is metabolic alkalosis. How far is it compensated? Click your answer.
pH 7.49PaCO₂ 41 mmHg (5.5 kPa)HCO₃⁻ 30 mmol/L
1uncompensated
2partially compensated
3fully compensated
4.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.31, PaCO₂ 29 mmHg (3.9 kPa), HCO₃⁻ 14 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.31PaCO₂ 29 mmHg (3.9 kPa)HCO₃⁻ 14 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice patient after a head injury does not open the eyes at all, makes no sounds and shows as the best motor response: no movement at all. Work out the GCS and classify the head injury by it. Click your answer.
1mild
2moderate
3severe
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). An adult weighs 62 kg and is 180 cm tall. Calculate the BMI and click the WHO weight category.
62 kg180 cm
1underweight
2healthy weight
3overweight
4obesity class I
5obesity class II
6obesity class III
7.Med-surg: cardiovascular & respiratoryMedium
Why are beta-blockers often started after a myocardial infarction?
AThey raise the heart rate to improve blood flow to the muscle
BThey reduce cholesterol in the blood
CThey lower the heart's oxygen demand and reduce arrhythmias
DThey dissolve the clot that is blocking the coronary artery
8.Med-surg: cardiovascular & respiratoryHard
A nurse reviews inhaler use with a patient who has asthma and uses a separate steroid preventer inhaler and a salbutamol reliever. Which statement shows a need for further teaching?
A"I rinse my mouth after the steroid inhaler."
B"I carry my blue reliever inhaler with me."
C"I use my steroid inhaler when I start to wheeze."
D"I use my steroid inhaler every day, even when I feel well."
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: t = 1004 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(1800 − 200)·3.14 = 5024 L
Duration
5024/5 = 1005 min → t = 1004 min
Answer
t = 1004 min
That is about 16 h 44 min.
2.Oxygen therapy & respiratory calculations
Answer: VT = 467 mL
Ventilation: minute ventilation V̇E = tidal volume × respiratory rate (normal adult about 5–8 L/min). Alveolar ventilation V̇A = (tidal volume − dead space) × rate, because the air in the airways (about 150 mL in an adult) takes no part in gas exchange. Lung-protective ventilation uses about 6 mL per kg of predicted body weight (PBW): men 50 + 0.91 × (height in cm − 152.4) kg, women 45.5 + 0.91 × (height in cm − 152.4) kg (with inches: 2.3 per inch above 60 in).
Predicted body weight
PBW = 50 + 0.91·(183 − 152.4) = 77.85 kg
Tidal volume
VT = 6·77.85 = 467.1 ≈ 467 mL
Answer
VT = 467 mL
3.Arterial blood gas interpretation
Answer: uncompensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.49: alkalaemia (above 7.45)
PaCO₂ 41 mmHg: normal (35–45)
HCO₃⁻ 30 mmol/L: high (22–26)
Compensation
uncompensated
Answer
uncompensated
4.Arterial blood gas interpretation
Answer: appropriate compensation
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·14 + 8 = 29 → 27–31 mmHg
Compare
measured: 29 mmHg → appropriate compensation
Answer
appropriate compensation
5.Clinical assessment scores
Answer: severe
Glasgow Coma Scale: add the best response in three areas. Eye opening E: 4 spontaneous, 3 to sound or speech, 2 to pressure, 1 none. Verbal V: 5 oriented, 4 confused, 3 inappropriate words, 2 incomprehensible sounds, 1 none. Motor M: 6 obeys commands, 5 localises, 4 normal flexion (withdraws), 3 abnormal flexion, 2 extension, 1 none. The total runs from 3 to 15. After a head injury, 13–15 is usually called mild, 9–12 moderate and 3–8 severe.
Score each area
E: does not open the eyes at all → 1
V: makes no sounds → 1
M: no movement at all → 1
Add
GCS = 1 + 1 + 1 = 3
Severity
GCS 3 → severe
Answer
severe
6.Clinical assessment scores
Answer: healthy weight
Body mass index: BMI = weight (kg)/height (m)², with the height converted to metres first. With pounds and inches, BMI = 703 × weight (lb)/height (in)². WHO adult categories: below 18.5 underweight, 18.5–24.9 healthy weight, 25.0–29.9 overweight, 30.0–34.9 obesity class I, 35.0–39.9 obesity class II and 40 or more obesity class III.
BMI
BMI = 62/1.8² = 19.14
Category
healthy weight
Answer
healthy weight
7.Med-surg: cardiovascular & respiratory
Answer: C · They lower the heart's oxygen demand and reduce arrhythmias
Why this is the answer
Beta-blockers slow the heart and reduce contractility, lowering myocardial oxygen demand, and protect against arrhythmias. They are particularly beneficial when the ejection fraction is reduced. They are used cautiously in heart block, severe bradycardia, acute heart failure and asthma.
Answer
C · They lower the heart's oxygen demand and reduce arrhythmias
8.Med-surg: cardiovascular & respiratory
Answer: C · "I use my steroid inhaler when I start to wheeze."
Why this is the answer
Inhaled corticosteroids are preventers that reduce airway inflammation over days to weeks and must be taken regularly. They do not relieve an acute wheeze. Unless the patient has a combined reliever and maintenance regimen, a short-acting bronchodilator is used for symptoms.
Answer
C · "I use my steroid inhaler when I start to wheeze."