Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A size D oxygen cylinder (factor 0.16 L/psi) reads 1250 psi and runs at 10 L/min. Keeping a safe residual of 200 psi, how many minutes t will it last? Round down to a whole minute.
1250 psif = 0.16 L/psi10 L/min200 psi
t = min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A patient with acute hypoxaemia and bilateral opacities, not explained by heart failure, has PaO₂ 14.5 kPa on 100% oxygen with a PEEP of 8 cmH₂O. Grade the ARDS severity with the Berlin definition. Click your answer.
PaO₂ 14.5 kPaFiO₂ 100%PEEP 8 cmH₂O
1above 300
2mild
3moderate
4severe
5not gradable: PEEP below 5
3.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 10 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 10 mmol/L
PaCO₂ = mmHg
4.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.20, PaCO₂ 21 mmHg (2.8 kPa), HCO₃⁻ 8 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.20PaCO₂ 21 mmHg (2.8 kPa)HCO₃⁻ 8 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A patient has a pulse of 83/min and a blood pressure of 150/98 mmHg. Find the shock index SI = HR/SBP. Round to two decimal places.
HR 83/minBP 150/98 mmHg
SI =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). Use the NEWS2 chart (SpO₂ scale 1) for these observations: respiration rate 12/min, SpO₂ 95% on supplemental oxygen, blood pressure 96/58 mmHg, pulse 44/min, alert, temperature 39.2 °C. Which clinical risk group does the patient fall into? Click it.
RR 12SpO₂ 95%O₂SBP 96HR 44AT 39.2 °C
1low
2low–medium
3medium
4high
7.Med-surg: cardiovascular & respiratoryMedium
When should an adult with cystic fibrosis take pancreatic enzyme capsules?
AWith all meals and snacks that contain fat
BOnly when they have diarrhoea
COnce a day on waking, at least an hour before any food
DOnly at bedtime
8.Med-surg: cardiovascular & respiratoryHard
A frightened young woman is breathing fast and has tingling fingers. Her blood gas shows pH 7.50 and a low PaCO₂. SpO₂ is 99% on air. What does this show?
ARespiratory acidosis from hypoventilation
BMetabolic acidosis from kidney failure
CRespiratory alkalosis from hyperventilation
DMetabolic alkalosis from vomiting
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: t = 16 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(1250 − 200)·0.16 = 168 L
Duration
168/10 = 16.8 min → t = 16 min
Answer
t = 16 min
2.Oxygen therapy & respiratory calculations
Answer: moderate
P/F ratio and ARDS (Berlin definition): P/F = PaO₂ (mmHg)/FiO₂ (as a fraction). With PEEP or CPAP of at least 5 cmH₂O, ARDS is graded mild for 200 < P/F ≤ 300, moderate for 100 < P/F ≤ 200 and severe for P/F ≤ 100 mmHg. The other Berlin criteria (onset within a week, bilateral opacities, not fully explained by heart failure) must also be met. PaO₂ in kPa × 7.5 gives mmHg. The ROX index (SpO₂/FiO₂)/respiratory rate is used to follow patients on high-flow nasal oxygen.
PEEP
PEEP 8 ≥ 5 cmH₂O
PaO₂ in mmHg
14.5·7.5 = 108.8 mmHg
P/F ratio
P/F = 108.8/1 = 108.8 mmHg
Berlin severity
moderate
Answer
moderate
3.Arterial blood gas interpretation
Answer: PaCO₂ = 23 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·10 + 8 = 23 mmHg
range: 21–25 mmHg
Answer
PaCO₂ = 23 mmHg
4.Arterial blood gas interpretation
Answer: appropriate compensation
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·8 + 8 = 20 → 18–22 mmHg
Compare
measured: 21 mmHg → appropriate compensation
Answer
appropriate compensation
5.Clinical assessment scores
Answer: SI = 0.55
Blood pressure values: pulse pressure PP = SBP − DBP. Mean arterial pressure MAP ≈ (SBP + 2·DBP)/3 = DBP + PP/3, an estimate based on the heart spending about two thirds of each beat in diastole at a normal heart rate (less accurate when the heart rate is fast); a MAP of at least about 65 mmHg is a common target for organ perfusion. The shock index SI = heart rate/SBP is normally about 0.5–0.7; a value above about 1 is a warning sign of shock.
Shock index
SI = 83/150 = 0.5533 ≈ 0.55
Answer
SI = 0.55
Within or below the usual 0.5–0.7.
6.Clinical assessment scores
Answer: high
NEWS2 (National Early Warning Score 2, Royal College of Physicians 2017): score each of the seven parameters with the chart (respiration rate, SpO₂ on scale 1, air or supplemental oxygen, systolic blood pressure, pulse, consciousness on the ACVPU scale and temperature) and add the scores. Clinical risk: 0–4 low; a score of 3 in any single parameter low–medium; 5–6 medium; 7 or more high. A total of 5 or more needs an urgent response.
Score each parameter
RR 12/min → 0
SpO₂ 95% → 1
on oxygen → 2
SBP 96 mmHg → 2
HR 44/min → 1
alert (A) → 0
T 39.2 °C → 2
Total and red scores
NEWS2 = 0 + 1 + 2 + 2 + 1 + 0 + 2 = 8
No parameter scores 3.
Risk group
high
Answer
high
A total of 5 or more calls for an urgent clinical response.
7.Med-surg: cardiovascular & respiratory
Answer: A · With all meals and snacks that contain fat
Why this is the answer
In CF, thick secretions block the pancreatic ducts, causing fat malabsorption and fatty stools. Enzyme capsules are taken with every meal and fat-containing snack, with the dose adjusted to fat intake. Fat-soluble vitamins (A, D, E, K) are also supplemented.
Answer
A · With all meals and snacks that contain fat
8.Med-surg: cardiovascular & respiratory
Answer: C · Respiratory alkalosis from hyperventilation
Why this is the answer
Hyperventilation blows off CO₂, causing respiratory alkalosis. The alkalosis lowers ionised calcium, causing tingling and carpopedal spasm. Normal oxygen saturation is reassuring, but organic causes such as PE, asthma or diabetic ketoacidosis must still be excluded.