Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A patient breathes 9 times a minute with a tidal volume of 360 mL. The anatomical dead space is 120 mL. Find the alveolar ventilation V̇A in L/min.
VT 360 mL9/minVD 120 mL
V̇A = L/min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A patient has Hb 158 g/L, SaO₂ 97%, PaO₂ 93 mmHg (12.4 kPa) and a cardiac output of 3.1 L/min. With CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), find the oxygen delivery DO₂ = CaO₂ × CO × 10 in mL/min.
A practice gas shows a metabolic acidosis with HCO₃⁻ 14 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 14 mmol/L
PaCO₂ = mmHg
4.Arterial blood gas interpretationHard
A practice gas shows a metabolic alkalosis with HCO₃⁻ 33 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 33 mmol/L
PaCO₂ = mmHg
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice patient is assessed with the Braden scale: sensory perception: completely limited; moisture: rarely moist; activity: bedfast; mobility: completely immobile; nutrition: very poor; friction and shear: no apparent problem. Find the Braden total B.
6–23
B =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). Use the NEWS2 chart (SpO₂ scale 1) for these observations: respiration rate 21/min, SpO₂ 99% on supplemental oxygen, blood pressure 142/86 mmHg, pulse 64/min, alert, temperature 37.3 °C. Which clinical risk group does the patient fall into? Click it.
RR 21SpO₂ 99%O₂SBP 142HR 64AT 37.3 °C
1low
2low–medium
3medium
4high
7.Med-surg: cardiovascular & respiratoryMedium
A patient is starting warfarin for a DVT. Why is heparin or LMWH also given for the first several days?
AHeparin improves the absorption of warfarin
BWarfarin takes several days to reach its full effect
CHeparin protects against bleeding from warfarin
DBoth drugs must always be continued together for life
8.Med-surg: cardiovascular & respiratoryHard
The monitor shows a regular broad-complex tachycardia at 180/min. The patient is alert with BP 126/78 mmHg and no chest pain. What is the most appropriate plan?
AStart chest compressions straight away and give a dose of IV adrenaline
BReassure the patient, as this is a normal rhythm
CRecord a 12-lead ECG, call senior help and anticipate an antiarrhythmic
DDeliver an unsynchronised shock immediately, before any other assessment
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: V̇A = 2.16 L/min
Ventilation: minute ventilation V̇E = tidal volume × respiratory rate (normal adult about 5–8 L/min). Alveolar ventilation V̇A = (tidal volume − dead space) × rate, because the air in the airways (about 150 mL in an adult) takes no part in gas exchange. Lung-protective ventilation uses about 6 mL per kg of predicted body weight (PBW): men 50 + 0.91 × (height in cm − 152.4) kg, women 45.5 + 0.91 × (height in cm − 152.4) kg (with inches: 2.3 per inch above 60 in).
Alveolar part of a breath
360 − 120 = 240 mL
Alveolar ventilation
V̇A = 240·9 = 2160 mL/min = 2.16 L/min
Answer
V̇A = 2.16 L/min
2.Oxygen therapy & respiratory calculations
Answer: DO₂ = 645.3 mL/min
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Oxygen content
158 g/L = 15.8 g/dL
CaO₂ = 1.34·15.8·0.97 + 0.003·93 = 20.82 mL/dL
Oxygen delivery
DO₂ = 20.82·3.1·10 = 645.3 mL/min
Answer
DO₂ = 645.3 mL/min
A normal resting adult value is about 1000 mL/min.
3.Arterial blood gas interpretation
Answer: PaCO₂ = 29 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·14 + 8 = 29 mmHg
range: 27–31 mmHg
Answer
PaCO₂ = 29 mmHg
4.Arterial blood gas interpretation
Answer: PaCO₂ = 44.1 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·33 + 21 = 44.1 mmHg
Answer
PaCO₂ = 44.1 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
5.Clinical assessment scores
Answer: B = 11
Braden scale: six subscales for pressure-injury risk. Sensory perception, moisture, activity, mobility and nutrition score 1 to 4, from the worst level (1) to no problem (4); friction and shear scores 1 to 3. The total runs from 6 to 23, and a lower total means a higher risk. Common bands: 19–23 not at risk, 15–18 mild risk, 13–14 moderate risk, 10–12 high risk and 9 or below very high risk.
Score each subscale
sensory perception: completely limited → 1
moisture: rarely moist → 4
activity: bedfast → 1
mobility: completely immobile → 1
nutrition: very poor → 1
friction and shear: no apparent problem → 3
Add
Braden total = 1 + 4 + 1 + 1 + 1 + 3 = 11
Answer
B = 11
6.Clinical assessment scores
Answer: low
NEWS2 (National Early Warning Score 2, Royal College of Physicians 2017): score each of the seven parameters with the chart (respiration rate, SpO₂ on scale 1, air or supplemental oxygen, systolic blood pressure, pulse, consciousness on the ACVPU scale and temperature) and add the scores. Clinical risk: 0–4 low; a score of 3 in any single parameter low–medium; 5–6 medium; 7 or more high. A total of 5 or more needs an urgent response.
Score each parameter
RR 21/min → 2
SpO₂ 99% → 0
on oxygen → 2
SBP 142 mmHg → 0
HR 64/min → 0
alert (A) → 0
T 37.3 °C → 0
Total and red scores
NEWS2 = 2 + 0 + 2 + 0 + 0 + 0 + 0 = 4
No parameter scores 3.
Risk group
low
Answer
low
7.Med-surg: cardiovascular & respiratory
Answer: B · Warfarin takes several days to reach its full effect
Why this is the answer
Warfarin reduces synthesis of vitamin K-dependent clotting factors, but existing factors take days to clear, and early on it can briefly increase clotting tendency. Heparin or LMWH is overlapped for at least five days and until the INR has been in range (usually ≥2) for at least 24 hours.
Answer
B · Warfarin takes several days to reach its full effect
8.Med-surg: cardiovascular & respiratory
Answer: C · Record a 12-lead ECG, call senior help and anticipate an antiarrhythmic
Why this is the answer
A broad-complex tachycardia is treated as ventricular tachycardia until proven otherwise. With a pulse and no adverse features (shock, syncope, chest pain or heart failure), a 12-lead ECG, electrolyte correction and drug treatment such as amiodarone are used, with expert help. Unstable patients need synchronised cardioversion; pulseless VT is defibrillated.
Answer
C · Record a 12-lead ECG, call senior help and anticipate an antiarrhythmic