Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A patient has Hb 136 g/L, SaO₂ 96% and PaO₂ 81 mmHg (10.8 kPa). Find the arterial oxygen content CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg) in mL O₂/dL.
Hb 136 g/LSaO₂ 96%PaO₂ 81 mmHg (10.8 kPa)
CaO₂ = mL/dL
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A patient with acute hypoxaemia and bilateral opacities, not explained by heart failure, has PaO₂ 7.1 kPa on 80% oxygen with a PEEP of 8 cmH₂O. Grade the ARDS severity with the Berlin definition. Click your answer.
PaO₂ 7.1 kPaFiO₂ 80%PEEP 8 cmH₂O
1above 300: no ARDS grade
2mild
3moderate
4severe
5not gradable: PEEP below 5
3.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 8 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 8 mmol/L
PaCO₂ = mmHg
4.Arterial blood gas interpretationHard
A practice gas shows a respiratory acidosis: pH 7.18, PaCO₂ 77 mmHg (10.3 kPa), HCO₃⁻ 28 mmol/L. Use the rules ‘HCO₃⁻ rises 1 mmol/L per 10 mmHg (acute) or 3.5 mmol/L per 10 mmHg (chronic)’ to classify it. Click your answer.
pH 7.18PaCO₂ 77 mmHg (10.3 kPa)HCO₃⁻ 28 mmol/L
1acute
2chronic
3acute on chronic
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice patient after a head injury does not open the eyes at all, makes no sounds and shows as the best motor response: no movement at all. Work out the GCS and classify the head injury by it. Click your answer.
1mild
2moderate
3severe
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). A practice patient is assessed with the Braden scale: sensory perception: very limited; moisture: occasionally moist; activity: bedfast; mobility: very limited; nutrition: probably inadequate; friction and shear: potential problem. Use the bands 19–23 not at risk, 15–18 mild, 13–14 moderate, 10–12 high and 9 or below very high. Click the risk level.
1not at risk
2mild risk
3moderate risk
4high risk
5very high risk
7.Med-surg: cardiovascular & respiratoryMedium
How should a patient with asthma record their peak flow at home?
ATake the average of ten blows after exercise
BTake one gentle blow once a week, at any time of day
CTake the best of three blows, ideally morning and evening
DBlow only during an asthma attack, never when well
8.Med-surg: cardiovascular & respiratoryHard
On a ventilated patient, the end-tidal CO₂ waveform suddenly drops to zero. What should the nurse suspect first?
AA rise in the patient's body temperature over the last hour
BNormal variation that needs no action
CA sudden improvement in the patient's lung function
DTube displacement, disconnection or obstruction
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: CaO₂ = 17.74 mL/dL
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Hb in g/dL
136 g/L = 13.6 g/dL
Bound oxygen
1.34·13.6·0.96 = 17.5 mL/dL
Dissolved oxygen
0.003·81 = 0.243 mL/dL
Oxygen content
CaO₂ = 17.5 + 0.243 = 17.74 mL/dL
Answer
CaO₂ = 17.74 mL/dL
2.Oxygen therapy & respiratory calculations
Answer: severe
P/F ratio and ARDS (Berlin definition): P/F = PaO₂ (mmHg)/FiO₂ (as a fraction). With PEEP or CPAP of at least 5 cmH₂O, ARDS is graded mild for 200 < P/F ≤ 300, moderate for 100 < P/F ≤ 200 and severe for P/F ≤ 100 mmHg. The other Berlin criteria (onset within a week, bilateral opacities, not fully explained by heart failure) must also be met. PaO₂ in kPa × 7.5 gives mmHg. The ROX index (SpO₂/FiO₂)/respiratory rate is used to follow patients on high-flow nasal oxygen.
PEEP
PEEP 8 ≥ 5 cmH₂O
PaO₂ in mmHg
7.1·7.5 = 53.25 mmHg
P/F ratio
P/F = 53.25/0.8 = 66.56 mmHg
Berlin severity
severe
Answer
severe
3.Arterial blood gas interpretation
Answer: PaCO₂ = 20 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·8 + 8 = 20 mmHg
range: 18–22 mmHg
Answer
PaCO₂ = 20 mmHg
4.Arterial blood gas interpretation
Answer: acute
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected HCO₃⁻
acute: 24 + 1·3.7 = 27.7 mmol/L
chronic: 24 + 3.5·3.7 = 36.95 mmol/L
Compare
measured: 28 mmol/L → acute
Answer
acute
5.Clinical assessment scores
Answer: severe
Glasgow Coma Scale: add the best response in three areas. Eye opening E: 4 spontaneous, 3 to sound or speech, 2 to pressure, 1 none. Verbal V: 5 oriented, 4 confused, 3 inappropriate words, 2 incomprehensible sounds, 1 none. Motor M: 6 obeys commands, 5 localises, 4 normal flexion (withdraws), 3 abnormal flexion, 2 extension, 1 none. The total runs from 3 to 15. After a head injury, 13–15 is usually called mild, 9–12 moderate and 3–8 severe.
Score each area
E: does not open the eyes at all → 1
V: makes no sounds → 1
M: no movement at all → 1
Add
GCS = 1 + 1 + 1 = 3
Severity
GCS 3 → severe
Answer
severe
6.Clinical assessment scores
Answer: high risk
Braden scale: six subscales for pressure-injury risk. Sensory perception, moisture, activity, mobility and nutrition score 1 to 4, from the worst level (1) to no problem (4); friction and shear scores 1 to 3. The total runs from 6 to 23, and a lower total means a higher risk. Common bands: 19–23 not at risk, 15–18 mild risk, 13–14 moderate risk, 10–12 high risk and 9 or below very high risk.
Score each subscale
sensory perception: very limited → 2
moisture: occasionally moist → 3
activity: bedfast → 1
mobility: very limited → 2
nutrition: probably inadequate → 2
friction and shear: potential problem → 2
Add
Braden total = 2 + 3 + 1 + 2 + 2 + 2 = 12
Risk level
12 → high risk
Answer
high risk
7.Med-surg: cardiovascular & respiratory
Answer: C · Take the best of three blows, ideally morning and evening
Why this is the answer
The patient stands or sits upright, takes a full breath and blows as hard and fast as possible, three times, recording the best. Regular readings show variability and guide the action plan, which uses the patient's own best value as the reference.
Answer
C · Take the best of three blows, ideally morning and evening
8.Med-surg: cardiovascular & respiratory
Answer: D · Tube displacement, disconnection or obstruction
Why this is the answer
A sudden loss of the capnography trace means no CO₂ is being detected: the tube may be dislodged, disconnected or blocked, or there may be cardiac arrest. The nurse checks the patient and circuit immediately, hand-ventilates if needed and calls for help.
Answer
D · Tube displacement, disconnection or obstruction