Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A size H oxygen cylinder (factor 3.14 L/psi) reads 1050 psi and runs at 4 L/min. Keeping a safe residual of 200 psi, how many minutes t will it last? Round down to a whole minute.
1050 psif = 3.14 L/psi4 L/min200 psi
t = min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A transfer will take 45 minutes. The size E cylinder (factor 0.28 L/psi) reads 1500 psi. Keeping a safe residual of 200 psi, what is the highest whole-number flow Q in L/min that lasts the whole transfer?
45 min1500 psif = 0.28 L/psi200 psi
Q = L/min
3.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 8 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 8 mmol/L
PaCO₂ = mmHg
4.Arterial blood gas interpretationHard
Practice values: Na⁺ 146, Cl⁻ 114, HCO₃⁻ 21 mmol/L and albumin 28 g/L. Find the albumin-corrected anion gap AGc = AG + 0.25·(40 − albumin).
Practice exercise (made-up values, not clinical guidance). A patient has a pulse of 128/min and a blood pressure of 106/58 mmHg. Find the shock index SI = HR/SBP. Round to two decimal places.
HR 128/minBP 106/58 mmHg
SI =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). Use the NEWS2 chart (SpO₂ scale 1) for these observations: respiration rate 16/min, SpO₂ 98% on supplemental oxygen, blood pressure 84/50 mmHg, pulse 132/min, alert, temperature 37.3 °C. Which clinical risk group does the patient fall into? Click it.
RR 16SpO₂ 98%O₂SBP 84HR 132AT 37.3 °C
1low
2low–medium
3medium
4high
7.Med-surg: cardiovascular & respiratoryMedium
Why is pyridoxine (vitamin B6) often given with isoniazid?
ATo prevent orange discolouration of urine
BTo prevent gout attacks
CTo prevent peripheral neuropathy
DTo prevent loss of colour vision
8.Med-surg: cardiovascular & respiratoryHard
A patient with a tracheostomy suddenly becomes distressed, and a suction catheter will not pass down the tube. What should the nurse do first?
ARemove the inner cannula
BGive a nebulised bronchodilator
CIncrease the oxygen and wait
DInflate the cuff with more air
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: t = 667 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(1050 − 200)·3.14 = 2669 L
Duration
2669/4 = 667.3 min → t = 667 min
Answer
t = 667 min
That is about 11 h 07 min.
2.Oxygen therapy & respiratory calculations
Answer: Q = 8 L/min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(1500 − 200)·0.28 = 364 L
Highest flow
364/45 = 8.089 L/min → Q = 8 L/min
Answer
Q = 8 L/min
3.Arterial blood gas interpretation
Answer: PaCO₂ = 20 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·8 + 8 = 20 mmHg
range: 18–22 mmHg
Answer
PaCO₂ = 20 mmHg
4.Arterial blood gas interpretation
Answer: AGc = 14 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 146 − (114 + 21) = 11
Correction for albumin
11 + 0.25·(40 − 28) = 14 mmol/L
Answer
AGc = 14 mmol/L
Above about 12 after correction: a high anion gap.
5.Clinical assessment scores
Answer: SI = 1.21
Blood pressure values: pulse pressure PP = SBP − DBP. Mean arterial pressure MAP ≈ (SBP + 2·DBP)/3 = DBP + PP/3, an estimate based on the heart spending about two thirds of each beat in diastole at a normal heart rate (less accurate when the heart rate is fast); a MAP of at least about 65 mmHg is a common target for organ perfusion. The shock index SI = heart rate/SBP is normally about 0.5–0.7; a value above about 1 is a warning sign of shock.
Shock index
SI = 128/106 = 1.208 ≈ 1.21
Answer
SI = 1.21
1 or more: a warning sign of shock in this practice case.
6.Clinical assessment scores
Answer: high
NEWS2 (National Early Warning Score 2, Royal College of Physicians 2017): score each of the seven parameters with the chart (respiration rate, SpO₂ on scale 1, air or supplemental oxygen, systolic blood pressure, pulse, consciousness on the ACVPU scale and temperature) and add the scores. Clinical risk: 0–4 low; a score of 3 in any single parameter low–medium; 5–6 medium; 7 or more high. A total of 5 or more needs an urgent response.
Score each parameter
RR 16/min → 0
SpO₂ 98% → 0
on oxygen → 2
SBP 84 mmHg → 3
HR 132/min → 3
alert (A) → 0
T 37.3 °C → 0
Total and red scores
NEWS2 = 0 + 0 + 2 + 3 + 3 + 0 + 0 = 8
At least one parameter scores 3.
Risk group
high
Answer
high
A total of 5 or more calls for an urgent clinical response.
7.Med-surg: cardiovascular & respiratory
Answer: C · To prevent peripheral neuropathy
Why this is the answer
Isoniazid increases pyridoxine loss, which can cause peripheral neuropathy, especially in people with diabetes, alcohol dependence, malnutrition or HIV. Pyridoxine prevents this. Isoniazid can also cause hepatitis. Ethambutol affects vision; pyrazinamide can cause gout.
Answer
C · To prevent peripheral neuropathy
8.Med-surg: cardiovascular & respiratory
Answer: A · Remove the inner cannula
Why this is the answer
Tracheostomy emergency guidance is to remove the inner cannula first, because it may be blocked with secretions. If the patient does not improve, the cuff is deflated and the tube may need to be removed. Oxygen is applied to the face and the stoma, and emergency help is called.