Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A patient has Hb 175 g/L, SaO₂ 96% and PaO₂ 82 mmHg (10.9 kPa). Find the arterial oxygen content CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg) in mL O₂/dL.
Hb 175 g/LSaO₂ 96%PaO₂ 82 mmHg (10.9 kPa)
CaO₂ = mL/dL
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A patient has Hb 140 g/L, SaO₂ 97%, PaO₂ 93 mmHg (12.4 kPa) and a cardiac output of 4.4 L/min. With CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), find the oxygen delivery DO₂ = CaO₂ × CO × 10 in mL/min.
A practice gas shows a metabolic acidosis with HCO₃⁻ 10 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 10 mmol/L
PaCO₂ = mmHg
4.Arterial blood gas interpretationHard
Practice values: Na⁺ 137, Cl⁻ 94 and HCO₃⁻ 15 mmol/L. Calculate the delta ratio (AG − 12)/(24 − HCO₃⁻), using AG = Na⁺ − (Cl⁻ + HCO₃⁻). Give two decimals.
Na⁺ 137 mmol/LCl⁻ 94 mmol/LHCO₃⁻ 15 mmol/L
delta ratio =
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). Use the NEWS2 chart (SpO₂ scale 1) for these observations: respiration rate 8/min, SpO₂ 95% on room air, blood pressure 136/82 mmHg, pulse 120/min, alert, temperature 36.8 °C. What is the NEWS2 total score?
RR 8SpO₂ 95%airSBP 136HR 120AT 36.8 °C
NEWS2 =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). The team aims for a mean arterial pressure of at least 70 mmHg. A patient’s systolic pressure is 122 mmHg. Using MAP = (SBP + 2·DBP)/3, what is the lowest diastolic pressure DBP that still gives a MAP of 70 mmHg?
MAP 70 mmHgSBP 122 mmHg
DBP = mmHg
7.Med-surg: cardiovascular & respiratoryMedium
A patient with heart failure asks why salt is being limited. Which explanation is correct?
ASodium raises the heart rate during sleep
BSodium directly weakens the contracting heart muscle
CSodium stops the diuretic tablets from being absorbed properly
DSodium makes the body retain water, which adds to congestion
8.Med-surg: cardiovascular & respiratoryHard
After cardiac catheterisation via the radial artery, which assessment is most important?
ACirculation, sensation and movement of the hand, and the site
BBowel sounds and abdominal girth every hour after the test
CUrine specific gravity every four hours
DPupil size and reaction to light every 15 minutes
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: CaO₂ = 22.76 mL/dL
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Hb in g/dL
175 g/L = 17.5 g/dL
Bound oxygen
1.34·17.5·0.96 = 22.51 mL/dL
Dissolved oxygen
0.003·82 = 0.246 mL/dL
Oxygen content
CaO₂ = 22.51 + 0.246 = 22.76 mL/dL
Answer
CaO₂ = 22.76 mL/dL
2.Oxygen therapy & respiratory calculations
Answer: DO₂ = 813 mL/min
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Oxygen content
140 g/L = 14 g/dL
CaO₂ = 1.34·14·0.97 + 0.003·93 = 18.48 mL/dL
Oxygen delivery
DO₂ = 18.48·4.4·10 = 813 mL/min
Answer
DO₂ = 813 mL/min
A normal resting adult value is about 1000 mL/min.
3.Arterial blood gas interpretation
Answer: PaCO₂ = 23 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·10 + 8 = 23 mmHg
range: 21–25 mmHg
Answer
PaCO₂ = 23 mmHg
4.Arterial blood gas interpretation
Answer: delta ratio = 1.778
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 137 − (94 + 15) = 28
Delta ratio
(28 − 12)/(24 − 15) = 16/9 = 1.778
Answer
delta ratio = 1.778
Between 1 and 2: a pure high anion gap acidosis.
5.Clinical assessment scores
Answer: NEWS2 = 6
NEWS2 (National Early Warning Score 2, Royal College of Physicians 2017): score each of the seven parameters with the chart (respiration rate, SpO₂ on scale 1, air or supplemental oxygen, systolic blood pressure, pulse, consciousness on the ACVPU scale and temperature) and add the scores. Clinical risk: 0–4 low; a score of 3 in any single parameter low–medium; 5–6 medium; 7 or more high. A total of 5 or more needs an urgent response.
Score each parameter
RR 8/min → 3
SpO₂ 95% → 1
on air → 0
SBP 136 mmHg → 0
HR 120/min → 2
alert (A) → 0
T 36.8 °C → 0
Add
NEWS2 = 3 + 1 + 0 + 0 + 2 + 0 + 0 = 6
Answer
NEWS2 = 6
6.Clinical assessment scores
Answer: DBP = 44 mmHg
Blood pressure values: pulse pressure PP = SBP − DBP. Mean arterial pressure MAP ≈ (SBP + 2·DBP)/3 = DBP + PP/3, an estimate based on the heart spending about two thirds of each beat in diastole at a normal heart rate (less accurate when the heart rate is fast); a MAP of at least about 65 mmHg is a common target for organ perfusion. The shock index SI = heart rate/SBP is normally about 0.5–0.7; a value above about 1 is a warning sign of shock.
Rearrange
DBP = (3·MAP − SBP)/2
Substitute
DBP = (3·70 − 122)/2 = 88/2 = 44 mmHg
Answer
DBP = 44 mmHg
7.Med-surg: cardiovascular & respiratory
Answer: D · Sodium makes the body retain water, which adds to congestion
Why this is the answer
Sodium retention leads to water retention, increasing circulating volume, preload and congestion. Limiting sodium and, in some patients, fluid helps control oedema and breathlessness. The exact limits are set by the prescriber.
Answer
D · Sodium makes the body retain water, which adds to congestion
8.Med-surg: cardiovascular & respiratory
Answer: A · Circulation, sensation and movement of the hand, and the site
Why this is the answer
After radial access, the compression device and puncture site are checked for bleeding or haematoma, and the hand for colour, warmth, capillary refill, sensation and movement. Radial artery occlusion and forearm compartment syndrome are possible complications.
Answer
A · Circulation, sensation and movement of the hand, and the site