Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A patient breathes 27 times a minute with a tidal volume of 550 mL. The anatomical dead space is 120 mL. Find the alveolar ventilation V̇A in L/min.
VT 550 mL27/minVD 120 mL
V̇A = L/min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A cylinder with a water capacity of 3 L is filled to 118 bar and runs at 10 L/min. The gas volume is about the water capacity × the pressure. In this exercise the cylinder is changed at 20 bar. How many minutes t until it must be changed? Round down to a whole minute.
3 L118 bar10 L/min20 bar
t = min
3.Arterial blood gas interpretationMedium
Practice values: Na⁺ 134 mmol/L, glucose 31.5 mmol/L and urea 4.3 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 134 mmol/Lglucose 31.5 mmol/Lurea 4.3 mmol/L
Osm = mOsm/kg
4.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 21% oxygen shows PaO₂ 71 mmHg (9.5 kPa) and PaCO₂ 43 mmHg (5.7 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Practice exercise (made-up values, not clinical guidance). A practice patient after a head injury opens the eyes only to pressure (a painful stimulus), makes no sounds and shows as the best motor response: abnormal flexion of the arms (decorticate posture). Work out the GCS and classify the head injury by it. Click your answer.
1mild
2moderate
3severe
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). Use the NEWS2 chart (SpO₂ scale 1) for these observations: respiration rate 14/min, SpO₂ 90% on room air, blood pressure 130/78 mmHg, pulse 82/min, unresponsive, temperature 36.1 °C. Which clinical risk group does the patient fall into? Click it.
RR 14SpO₂ 90%airSBP 130HR 82UT 36.1 °C
1low
2low–medium
3medium
4high
7.Med-surg: cardiovascular & respiratoryMedium
How should subcutaneous enoxaparin from a prefilled syringe be given?
AInto the same abdominal site each day, then massaged
BAs a rapid intravenous bolus through a cannula
CInto the deltoid muscle, after first expelling the air bubble
DInto the abdomen, leaving the air bubble in, without rubbing
8.Med-surg: cardiovascular & respiratoryHard
A patient's blood gas shows pH 7.26, PaCO₂ 9.0 kPa (68 mmHg) and bicarbonate 25 mmol/L. What does this show?
AAcute respiratory acidosis
BRespiratory alkalosis
CMetabolic acidosis with compensation
DMetabolic alkalosis
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: V̇A = 11.61 L/min
Ventilation: minute ventilation V̇E = tidal volume × respiratory rate (normal adult about 5–8 L/min). Alveolar ventilation V̇A = (tidal volume − dead space) × rate, because the air in the airways (about 150 mL in an adult) takes no part in gas exchange. Lung-protective ventilation uses about 6 mL per kg of predicted body weight (PBW): men 50 + 0.91 × (height in cm − 152.4) kg, women 45.5 + 0.91 × (height in cm − 152.4) kg (with inches: 2.3 per inch above 60 in).
Alveolar part of a breath
550 − 120 = 430 mL
Alveolar ventilation
V̇A = 430·27 = 11610 mL/min = 11.61 L/min
Answer
V̇A = 11.61 L/min
2.Oxygen therapy & respiratory calculations
Answer: t = 29 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable gas
3·(118 − 20) = 294 L
Duration
294/10 = 29.4 min → t = 29 min
Answer
t = 29 min
3.Arterial blood gas interpretation
Answer: Osm = 304 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·134 + 31.5 + 4.3 = 303.8 ≈ 304 mOsm/kg
Answer
Osm = 304 mOsm/kg
4.Arterial blood gas interpretation
Answer: A–a gradient = 24.98 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Glasgow Coma Scale: add the best response in three areas. Eye opening E: 4 spontaneous, 3 to sound or speech, 2 to pressure, 1 none. Verbal V: 5 oriented, 4 confused, 3 inappropriate words, 2 incomprehensible sounds, 1 none. Motor M: 6 obeys commands, 5 localises, 4 normal flexion (withdraws), 3 abnormal flexion, 2 extension, 1 none. The total runs from 3 to 15. After a head injury, 13–15 is usually called mild, 9–12 moderate and 3–8 severe.
Score each area
E: opens the eyes only to pressure (a painful stimulus) → 2
V: makes no sounds → 1
M: abnormal flexion of the arms (decorticate posture) → 3
Add
GCS = 2 + 1 + 3 = 6
Severity
GCS 6 → severe
Answer
severe
6.Clinical assessment scores
Answer: medium
NEWS2 (National Early Warning Score 2, Royal College of Physicians 2017): score each of the seven parameters with the chart (respiration rate, SpO₂ on scale 1, air or supplemental oxygen, systolic blood pressure, pulse, consciousness on the ACVPU scale and temperature) and add the scores. Clinical risk: 0–4 low; a score of 3 in any single parameter low–medium; 5–6 medium; 7 or more high. A total of 5 or more needs an urgent response.
Score each parameter
RR 14/min → 0
SpO₂ 90% → 3
on air → 0
SBP 130 mmHg → 0
HR 82/min → 0
unresponsive (U) → 3
T 36.1 °C → 0
Total and red scores
NEWS2 = 0 + 3 + 0 + 0 + 0 + 3 + 0 = 6
At least one parameter scores 3.
Risk group
medium
Answer
medium
A total of 5 or more calls for an urgent clinical response.
7.Med-surg: cardiovascular & respiratory
Answer: D · Into the abdomen, leaving the air bubble in, without rubbing
Why this is the answer
Prefilled LMWH syringes contain an air bubble that is usually left in so the full dose is delivered. Injecting into a skin fold of the abdomen (away from the umbilicus), rotating sites and not rubbing afterwards reduce bruising and haematoma.
Answer
D · Into the abdomen, leaving the air bubble in, without rubbing
8.Med-surg: cardiovascular & respiratory
Answer: A · Acute respiratory acidosis
Why this is the answer
A low pH with raised PaCO₂ is respiratory acidosis. A normal bicarbonate (about 22–26 mmol/L) shows the kidneys have not yet compensated, so the problem is acute, as in opioid toxicity, exhaustion or an acute COPD exacerbation. Treatment targets ventilation.