Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A size H oxygen cylinder (factor 3.14 L/psi) reads 550 psi and runs at 2 L/min. Keeping a safe residual of 200 psi, how many minutes t will it last? Round down to a whole minute.
550 psif = 3.14 L/psi2 L/min200 psi
t = min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A patient has Hb 165 g/L, SaO₂ 95%, PaO₂ 78 mmHg (10.4 kPa) and a cardiac output of 7.8 L/min. With CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), find the oxygen delivery DO₂ = CaO₂ × CO × 10 in mL/min.
Practice values: Na⁺ 132 mmol/L, glucose 20.9 mmol/L and urea 9.2 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 132 mmol/Lglucose 20.9 mmol/Lurea 9.2 mmol/L
Osm = mOsm/kg
4.Arterial blood gas interpretationHard
Practice values: Na⁺ 142, Cl⁻ 110, HCO₃⁻ 16 mmol/L and albumin 25 g/L. Find the albumin-corrected anion gap AGc = AG + 0.25·(40 − albumin).
Practice exercise (made-up values, not clinical guidance). A practice patient is assessed with the Braden scale: sensory perception: no impairment; moisture: rarely moist; activity: walks frequently; mobility: very limited; nutrition: probably inadequate; friction and shear: problem. Find the Braden total B.
6–23
B =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). At 1 minute after birth, a practice newborn has blue or pale skin all over, no heartbeat, no response to stimulation, limp limbs with no muscle tone and no breathing. Score the APGAR and click how the score is interpreted.
1reassuring
2moderately abnormal
3low
7.Med-surg: cardiovascular & respiratoryMedium
According to current guidance, when should oxygen be given to a patient with an acute coronary syndrome?
ANever, because oxygen harms heart muscle
BOnly once the troponin result is available
COnly when SpO₂ is below the target range
DAlways at 15 L/min, whatever the saturation
8.Med-surg: cardiovascular & respiratoryHard
A patient with a confirmed calf DVT has started therapeutic anticoagulation and asks whether they must stay in bed. What is the most accurate answer?
AThe leg should be massaged before each walk
BWalking is not allowed until the clot has fully dissolved
CStrict bed rest is needed for at least two weeks
DWalking as tolerated is usually encouraged once treated
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: t = 549 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(550 − 200)·3.14 = 1099 L
Duration
1099/2 = 549.5 min → t = 549 min
Answer
t = 549 min
That is about 9 h 09 min.
2.Oxygen therapy & respiratory calculations
Answer: DO₂ = 1657 mL/min
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Oxygen content
165 g/L = 16.5 g/dL
CaO₂ = 1.34·16.5·0.95 + 0.003·78 = 21.24 mL/dL
Oxygen delivery
DO₂ = 21.24·7.8·10 = 1657 mL/min
Answer
DO₂ = 1657 mL/min
A normal resting adult value is about 1000 mL/min.
3.Arterial blood gas interpretation
Answer: Osm = 294 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·132 + 20.9 + 9.2 = 294.1 ≈ 294 mOsm/kg
Answer
Osm = 294 mOsm/kg
4.Arterial blood gas interpretation
Answer: AGc = 19.75 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 142 − (110 + 16) = 16
Correction for albumin
16 + 0.25·(40 − 25) = 19.75 mmol/L
Answer
AGc = 19.75 mmol/L
Above about 12 after correction: a high anion gap.
5.Clinical assessment scores
Answer: B = 17
Braden scale: six subscales for pressure-injury risk. Sensory perception, moisture, activity, mobility and nutrition score 1 to 4, from the worst level (1) to no problem (4); friction and shear scores 1 to 3. The total runs from 6 to 23, and a lower total means a higher risk. Common bands: 19–23 not at risk, 15–18 mild risk, 13–14 moderate risk, 10–12 high risk and 9 or below very high risk.
Score each subscale
sensory perception: no impairment → 4
moisture: rarely moist → 4
activity: walks frequently → 4
mobility: very limited → 2
nutrition: probably inadequate → 2
friction and shear: problem → 1
Add
Braden total = 4 + 4 + 4 + 2 + 2 + 1 = 17
Answer
B = 17
6.Clinical assessment scores
Answer: low
APGAR score: five signs, each scored 0, 1 or 2, checked at 1 and 5 minutes after birth. Appearance (colour): blue or pale 0, pink body with blue extremities 1, pink all over 2. Pulse: absent 0, below 100/min 1, 100/min or more 2. Grimace (reflex irritability): none 0, grimace 1, cry, cough or sneeze 2. Activity (tone): limp 0, some flexion 1, active movement 2. Respiration: absent 0, slow or irregular with a weak cry 1, good with a strong cry 2. A total of 7–10 is reassuring, 4–6 moderately abnormal and 0–3 low.
Score each sign
Appearance: blue or pale skin all over → 0
Pulse: 0 → 0
Grimace: no response to stimulation → 0
Activity: limp limbs with no muscle tone → 0
Respiration: no breathing → 0
Add
APGAR = 0 + 0 + 0 + 0 + 0 = 0
Interpretation
0 → low
Answer
low
7.Med-surg: cardiovascular & respiratory
Answer: C · Only when SpO₂ is below the target range
Why this is the answer
Routine high-flow oxygen in patients who are not hypoxaemic offers no benefit and may increase infarct size. Oxygen is given when saturation falls below the target (for example below 90% in some guidelines, below 94% in others).
Answer
C · Only when SpO₂ is below the target range
8.Med-surg: cardiovascular & respiratory
Answer: D · Walking as tolerated is usually encouraged once treated
Why this is the answer
Early mobilisation with effective anticoagulation does not increase the risk of pulmonary embolism and may reduce pain, swelling and post-thrombotic syndrome. Routine bed rest is no longer recommended. Massage of the affected leg should be avoided.
Answer
D · Walking as tolerated is usually encouraged once treated