Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A size H oxygen cylinder (factor 3.14 L/psi) reads 850 psi and runs at 10 L/min. Keeping a safe residual of 200 psi, how many minutes t will it last? Round down to a whole minute.
850 psif = 3.14 L/psi10 L/min200 psi
t = min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A ventilated woman is 178 cm tall and weighs 89 kg. Lung-protective ventilation is set at 6 mL per kg of predicted body weight. Using PBW = 45.5 + 0.91 × (height cm − 152.4) kg, find the tidal volume VT to the nearest mL.
178 cm89 kg6 mL/kg
VT = mL
3.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.32, PaCO₂ 26 mmHg (3.5 kPa) and HCO₃⁻ 13 mmol/L. The primary disorder is metabolic acidosis. How far is it compensated? Click your answer.
pH 7.32PaCO₂ 26 mmHg (3.5 kPa)HCO₃⁻ 13 mmol/L
1uncompensated
2partially compensated
3fully compensated
4.Arterial blood gas interpretationHard
Practice values: Na⁺ 139, Cl⁻ 93 and HCO₃⁻ 17 mmol/L. Calculate the delta ratio (AG − 12)/(24 − HCO₃⁻), using AG = Na⁺ − (Cl⁻ + HCO₃⁻). Give two decimals.
Na⁺ 139 mmol/LCl⁻ 93 mmol/LHCO₃⁻ 17 mmol/L
delta ratio =
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice chart records GCS 8, with E3 and V2. What motor score M was recorded, and which response does it describe? Give the number.
GCS 8E3V2
M =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). The team aims for a mean arterial pressure of at least 65 mmHg. A patient’s systolic pressure is 121 mmHg. Using MAP = (SBP + 2·DBP)/3, what is the lowest diastolic pressure DBP that still gives a MAP of 65 mmHg?
MAP 65 mmHgSBP 121 mmHg
DBP = mmHg
7.Med-surg: cardiovascular & respiratoryMedium
A patient with COPD is prescribed long-term oxygen therapy. How many hours a day is it usually needed to improve survival?
AOnly when walking outside
BAt least 15 hours a day
COnly during meals
DAbout one hour each morning
8.Med-surg: cardiovascular & respiratoryHard
A fit 24-year-old marathon runner has a resting heart rate of 46/min on admission for minor surgery. He has no dizziness, chest pain or breathlessness, and his BP is 118/70 mmHg. What is the appropriate response?
ACancel the surgery and arrange a permanent pacemaker urgently
BStart chest compressions
CDocument and report it, as this is often normal in an athlete
DGive IV atropine straight away to bring the rate above 60/min
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: t = 204 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(850 − 200)·3.14 = 2041 L
Duration
2041/10 = 204.1 min → t = 204 min
Answer
t = 204 min
That is about 3 h 24 min.
2.Oxygen therapy & respiratory calculations
Answer: VT = 413 mL
Ventilation: minute ventilation V̇E = tidal volume × respiratory rate (normal adult about 5–8 L/min). Alveolar ventilation V̇A = (tidal volume − dead space) × rate, because the air in the airways (about 150 mL in an adult) takes no part in gas exchange. Lung-protective ventilation uses about 6 mL per kg of predicted body weight (PBW): men 50 + 0.91 × (height in cm − 152.4) kg, women 45.5 + 0.91 × (height in cm − 152.4) kg (with inches: 2.3 per inch above 60 in).
Predicted body weight
PBW = 45.5 + 0.91·(178 − 152.4) = 68.8 kg
Tidal volume
VT = 6·68.8 = 412.8 ≈ 413 mL
Answer
VT = 413 mL
3.Arterial blood gas interpretation
Answer: partially compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.32: acidaemia (below 7.35)
PaCO₂ 26 mmHg: low (35–45)
HCO₃⁻ 13 mmol/L: low (22–26)
Compensation
partially compensated
Answer
partially compensated
4.Arterial blood gas interpretation
Answer: delta ratio = 2.429
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 139 − (93 + 17) = 29
Delta ratio
(29 − 12)/(24 − 17) = 17/7 = 2.429
Answer
delta ratio = 2.429
Above 2: an added metabolic alkalosis.
5.Clinical assessment scores
Answer: M = 3
Glasgow Coma Scale: add the best response in three areas. Eye opening E: 4 spontaneous, 3 to sound or speech, 2 to pressure, 1 none. Verbal V: 5 oriented, 4 confused, 3 inappropriate words, 2 incomprehensible sounds, 1 none. Motor M: 6 obeys commands, 5 localises, 4 normal flexion (withdraws), 3 abnormal flexion, 2 extension, 1 none. The total runs from 3 to 15. After a head injury, 13–15 is usually called mild, 9–12 moderate and 3–8 severe.
Motor score
M = 8 − 3 − 2 = 3
M3: abnormal flexion of the arms (decorticate posture)
Answer
M = 3
6.Clinical assessment scores
Answer: DBP = 37 mmHg
Blood pressure values: pulse pressure PP = SBP − DBP. Mean arterial pressure MAP ≈ (SBP + 2·DBP)/3 = DBP + PP/3, an estimate based on the heart spending about two thirds of each beat in diastole at a normal heart rate (less accurate when the heart rate is fast); a MAP of at least about 65 mmHg is a common target for organ perfusion. The shock index SI = heart rate/SBP is normally about 0.5–0.7; a value above about 1 is a warning sign of shock.
Rearrange
DBP = (3·MAP − SBP)/2
Substitute
DBP = (3·65 − 121)/2 = 74/2 = 37 mmHg
Answer
DBP = 37 mmHg
7.Med-surg: cardiovascular & respiratory
Answer: B · At least 15 hours a day
Why this is the answer
Long-term oxygen therapy improves survival in COPD with chronic hypoxaemia when used for at least 15 hours a day, including overnight. Patients must not smoke, because of the fire risk. Ambulatory oxygen for exercise is a separate assessment.
Answer
B · At least 15 hours a day
8.Med-surg: cardiovascular & respiratory
Answer: C · Document and report it, as this is often normal in an athlete
Why this is the answer
Endurance training increases vagal tone and stroke volume, so resting rates in the 40s can be normal. Without symptoms or haemodynamic compromise, no treatment is needed, though it is recorded and the team informed. Symptomatic bradycardia is treated.
Answer
C · Document and report it, as this is often normal in an athlete