Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A patient breathes 29 times a minute with a tidal volume of 340 mL. The anatomical dead space is 120 mL. Find the alveolar ventilation V̇A in L/min.
VT 340 mL29/minVD 120 mL
V̇A = L/min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A patient has Hb 93 g/L, SaO₂ 98%, PaO₂ 98 mmHg (13.1 kPa) and a cardiac output of 5.2 L/min. With CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), find the oxygen delivery DO₂ = CaO₂ × CO × 10 in mL/min.
Practice values: Na⁺ 148 mmol/L, glucose 4.5 mmol/L and urea 13.8 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 148 mmol/Lglucose 4.5 mmol/Lurea 13.8 mmol/L
Osm = mOsm/kg
4.Arterial blood gas interpretationHard
A practice gas shows a metabolic alkalosis with HCO₃⁻ 39 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 39 mmol/L
PaCO₂ = mmHg
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice patient is assessed with the Morse fall scale: history of falling in the last 3 months: no; secondary diagnosis: yes; ambulatory aid: holds on to furniture; IV therapy or saline lock: no; gait: weak; mental status: overestimates or forgets limits. Find the Morse total MFS.
0–125
MFS =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). The team aims for a mean arterial pressure of at least 70 mmHg. A patient’s systolic pressure is 112 mmHg. Using MAP = (SBP + 2·DBP)/3, what is the lowest diastolic pressure DBP that still gives a MAP of 70 mmHg?
MAP 70 mmHgSBP 112 mmHg
DBP = mmHg
7.Med-surg: cardiovascular & respiratoryMedium
A patient on nasal cannula oxygen breathes mainly through the mouth. What is the most accurate statement?
AIt can still work, because oxygen collects in the nasopharynx
BThe cannula should be placed in the mouth
CIt has no effect at all in mouth breathers and must be stopped
DThe flow must be increased to 15 L/min to make it work at all
8.Med-surg: cardiovascular & respiratoryHard
A one-way speaking valve is fitted to a patient's tracheostomy tube while the cuff is still inflated. What is the danger?
AThere is no danger, as the valve works with any cuff
BThe valve will humidify the air too much
CThe patient cannot breathe out and may suffocate
DThe patient will speak too loudly
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: V̇A = 6.38 L/min
Ventilation: minute ventilation V̇E = tidal volume × respiratory rate (normal adult about 5–8 L/min). Alveolar ventilation V̇A = (tidal volume − dead space) × rate, because the air in the airways (about 150 mL in an adult) takes no part in gas exchange. Lung-protective ventilation uses about 6 mL per kg of predicted body weight (PBW): men 50 + 0.91 × (height in cm − 152.4) kg, women 45.5 + 0.91 × (height in cm − 152.4) kg (with inches: 2.3 per inch above 60 in).
Alveolar part of a breath
340 − 120 = 220 mL
Alveolar ventilation
V̇A = 220·29 = 6380 mL/min = 6.38 L/min
Answer
V̇A = 6.38 L/min
2.Oxygen therapy & respiratory calculations
Answer: DO₂ = 650.4 mL/min
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Oxygen content
93 g/L = 9.3 g/dL
CaO₂ = 1.34·9.3·0.98 + 0.003·98 = 12.51 mL/dL
Oxygen delivery
DO₂ = 12.51·5.2·10 = 650.4 mL/min
Answer
DO₂ = 650.4 mL/min
A normal resting adult value is about 1000 mL/min.
3.Arterial blood gas interpretation
Answer: Osm = 314 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·148 + 4.5 + 13.8 = 314.3 ≈ 314 mOsm/kg
Answer
Osm = 314 mOsm/kg
4.Arterial blood gas interpretation
Answer: PaCO₂ = 48.3 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·39 + 21 = 48.3 mmHg
Answer
PaCO₂ = 48.3 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
5.Clinical assessment scores
Answer: MFS = 70
Morse fall scale: six items. History of falling: no 0, yes 25. Secondary diagnosis: no 0, yes 15. Ambulatory aid: none, bed rest or nurse assistance 0; crutches, cane or walker 15; holding on to furniture 30. IV therapy or saline lock: no 0, yes 20. Gait: normal, bed rest or wheelchair 0; weak 10; impaired 20. Mental status: knows own limits 0; overestimates or forgets limits 15. The total runs from 0 to 125. Risk cut-offs differ between hospitals; a common set is 0–24 low, 25–44 moderate and 45 or more high.
Score each item
history of falling in the last 3 months: no → 0
secondary diagnosis: yes → 15
ambulatory aid: holds on to furniture → 30
IV therapy or saline lock: no → 0
gait: weak → 10
mental status: overestimates or forgets limits → 15
Add
Morse total = 0 + 15 + 30 + 0 + 10 + 15 = 70
Answer
MFS = 70
6.Clinical assessment scores
Answer: DBP = 49 mmHg
Blood pressure values: pulse pressure PP = SBP − DBP. Mean arterial pressure MAP ≈ (SBP + 2·DBP)/3 = DBP + PP/3, an estimate based on the heart spending about two thirds of each beat in diastole at a normal heart rate (less accurate when the heart rate is fast); a MAP of at least about 65 mmHg is a common target for organ perfusion. The shock index SI = heart rate/SBP is normally about 0.5–0.7; a value above about 1 is a warning sign of shock.
Rearrange
DBP = (3·MAP − SBP)/2
Substitute
DBP = (3·70 − 112)/2 = 98/2 = 49 mmHg
Answer
DBP = 49 mmHg
7.Med-surg: cardiovascular & respiratory
Answer: A · It can still work, because oxygen collects in the nasopharynx
Why this is the answer
Studies show that mouth breathing still draws in oxygen from the nasopharynx, so nasal cannulae can work. The effect is judged by the SpO₂, and the device is changed if targets are not reached. Cannulae are never placed in the mouth.
Answer
A · It can still work, because oxygen collects in the nasopharynx
8.Med-surg: cardiovascular & respiratory
Answer: C · The patient cannot breathe out and may suffocate
Why this is the answer
A speaking valve opens on inspiration and closes on expiration, so exhaled air must pass around the tube and up through the larynx. If the cuff is inflated, air cannot escape, causing air trapping and respiratory arrest. The cuff must be fully deflated first.
Answer
C · The patient cannot breathe out and may suffocate