Respiratory Care and Oxygen Therapy: cram pack

Formula sheets, the key method steps for every topic and 8 practice problems, with full solutions at the back.

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1Formulas and methods

Oxygen therapy & respiratory calculations

Nasal cannula
FiO₂ ≈ 21% + 4% × L/min (1–6 L/min)
Cylinder duration
min = (psi − 200) × factor / (L/min); D 0.16, E 0.28, H 3.14 L/psi
Minute and alveolar ventilation
V̇E = VT·f, V̇A = (VT − VD)·f
Predicted body weight
men 50 + 0.91 × (cm − 152.4); women 45.5 + 0.91 × (cm − 152.4)
P/F ratio (Berlin, PEEP ≥ 5)
mild > 200–300, moderate > 100–200, severe ≤ 100 mmHg
Oxygen content
CaO₂ = 1.34·Hb·SaO₂ + 0.003·PaO₂
Oxygen delivery
DO₂ = CaO₂ × CO × 10
ROX index
(SpO₂/FiO₂)/RR

Method

  1. Put every value in the units of the formula: FiO₂ and SaO₂ as fractions, PaO₂ in mmHg, Hb in g/dL.
  2. For a cylinder, subtract the safe residual, multiply by the cylinder factor and divide by the flow.
  3. Round cylinder times and flows down, never up.
  4. For the P/F ratio, check the PEEP first, then divide PaO₂ by FiO₂ and compare with 300, 200 and 100 mmHg.
  5. For ventilation, subtract the dead space for alveolar ventilation and use the predicted body weight for tidal volumes.

Arterial blood gas interpretation

Normal ranges
pH 7.35–7.45, PaCO₂ 35–45 mmHg (4.7–6.0 kPa), HCO₃⁻ 22–26 mmol/L
ROME
Respiratory: PaCO₂ opposite to pH; Metabolic: HCO₃⁻ equal to pH
Winter’s formula
PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2
Metabolic alkalosis
PaCO₂ ≈ 0.7·HCO₃⁻ + 21
Anion gap
AG = Na⁺ − (Cl⁻ + HCO₃⁻) ≈ 8–12
Albumin-corrected gap
AG + 2.5·(4.0 − alb g/dL) = AG + 0.25·(40 − alb g/L)
Delta ratio
(AG − 12)/(24 − HCO₃⁻)
P/F ratio
PaO₂/FiO₂
Alveolar gas equation
PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8
Serum osmolality
2·Na⁺ + glucose + urea (2·Na⁺ + glucose/18 + BUN/2.8)

Method

  1. Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
  2. Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
  3. Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
  4. In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
  5. Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.

Clinical assessment scores

Glasgow Coma Scale
GCS = E (1–4) + V (1–5) + M (1–6) = 3–15
APGAR
5 signs × 0–2 = 0–10; 7–10 reassuring, 4–6 moderately abnormal, 0–3 low
Braden scale
5 × (1–4) + 1 × (1–3) = 6–23; ≤ 18 at risk
Morse fall scale
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²

Method

  1. Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
  2. Score every item separately, matching the description to its level.
  3. Add the item scores and check that the total lies inside the range.
  4. Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
  5. For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².

Med-surg: cardiovascular & respiratory

Method

  1. Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
  2. Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
  3. Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
  4. Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
  5. Choose the safe first action, then escalate and reassess.

2Practice problems

1.Oxygen therapy & respiratory calculationsMedium
1800psiEf = 0.28 L/psi3 L/minresidual 200 psit = ? min

Practice exercise (made-up values, not clinical guidance). A size E oxygen cylinder (factor 0.28 L/psi) reads 1800 psi and runs at 3 L/min. Keeping a safe residual of 200 psi, how many minutes t will it last? Round down to a whole minute.

1800 psif = 0.28 L/psi3 L/min200 psi
t = min
2.Oxygen therapy & respiratory calculationsHard
133 bar10 L6 L/min20 bart = ? min

Practice exercise (made-up values, not clinical guidance). A cylinder with a water capacity of 10 L is filled to 133 bar and runs at 6 L/min. The gas volume is about the water capacity × the pressure. In this exercise the cylinder is changed at 20 bar. How many minutes t until it must be changed? Round down to a whole minute.

10 L133 bar6 L/min20 bar
t = min
3.Arterial blood gas interpretationMedium

Practice values: Na⁺ 139 mmol/L, glucose 30.4 mmol/L and urea 19 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.

Na⁺ 139 mmol/Lglucose 30.4 mmol/Lurea 19 mmol/L
Osm = mOsm/kg
4.Arterial blood gas interpretationHard

At sea level, a practice gas taken on 35% oxygen shows PaO₂ 60 mmHg (8.0 kPa) and PaCO₂ 44 mmHg (5.9 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.

FiO₂ 35%PaO₂ 60 mmHg (8.0 kPa)PaCO₂ 44 mmHg (5.9 kPa)
A–a gradient = mmHg
5.Clinical assessment scoresMedium
9954SBPDBPmmHgHR 90/min · SI = ?

Practice exercise (made-up values, not clinical guidance). A patient has a pulse of 90/min and a blood pressure of 99/54 mmHg. Find the shock index SI = HR/SBP. Round to two decimal places.

HR 90/minBP 99/54 mmHg
SI =
6.Clinical assessment scoresHard
underweighthealthy weightoverweightobesity class Iobesity class IIobesity class III

Practice exercise (made-up values, not clinical guidance). An adult weighs 120 kg and is 191 cm tall. Calculate the BMI and click the WHO weight category.

120 kg191 cm
  1. 1underweight
  2. 2healthy weight
  3. 3overweight
  4. 4obesity class I
  5. 5obesity class II
  6. 6obesity class III
7.Med-surg: cardiovascular & respiratoryMedium

How do clopidogrel and ticagrelor work?

  1. AThey dissolve fibrin in existing clots
  2. BThey inhibit the vitamin K-dependent clotting factors in the liver
  3. CThey block the platelet ADP (P2Y12) receptor
  4. DThey directly inhibit thrombin in the plasma
8.Med-surg: cardiovascular & respiratoryHard

A patient with COPD who is known to retain CO₂ arrives on 15 L/min oxygen. They are now drowsy with SpO₂ 99%. What is the most appropriate action?

  1. AGive a sedative to help the patient rest
  2. BReduce the oxygen to aim for 88–92% and get a blood gas
  3. CKeep the oxygen at 15 L/min because the saturation is excellent
  4. DRemove the oxygen completely and observe

3Solutions

1.Oxygen therapy & respiratory calculations

Answer: t = 149 min

Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).

Usable litres

(1800 − 200)·0.28 = 448 L

Duration

448/3 = 149.3 min → t = 149 min

Answer

t = 149 min

That is about 2 h 29 min.

2.Oxygen therapy & respiratory calculations

Answer: t = 188 min

Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).

Usable gas

10·(133 − 20) = 1130 L

Duration

1130/6 = 188.3 min → t = 188 min

Answer

t = 188 min

That is about 3 h 08 min.

3.Arterial blood gas interpretation

Answer: Osm = 327 mOsm/kg

Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.

Calculated osmolality

Osm = 2·139 + 30.4 + 19 = 327.4 ≈ 327 mOsm/kg

Answer

Osm = 327 mOsm/kg
4.Arterial blood gas interpretation

Answer: A–a gradient = 134.5 mmHg

Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.

Alveolar oxygen

PAO₂ = 0.35·713 − 44/0.8 = 249.5 − 55 = 194.5 mmHg

Gradient

A–a = 194.5 − 60 = 134.5 mmHg

Answer

A–a gradient = 134.5 mmHg
5.Clinical assessment scores

Answer: SI = 0.91

Blood pressure values: pulse pressure PP = SBP − DBP. Mean arterial pressure MAP ≈ (SBP + 2·DBP)/3 = DBP + PP/3, an estimate based on the heart spending about two thirds of each beat in diastole at a normal heart rate (less accurate when the heart rate is fast); a MAP of at least about 65 mmHg is a common target for organ perfusion. The shock index SI = heart rate/SBP is normally about 0.5–0.7; a value above about 1 is a warning sign of shock.

Shock index

SI = 90/99 = 0.9091 ≈ 0.91

Answer

SI = 0.91

Above the usual 0.5–0.7.

6.Clinical assessment scores

Answer: obesity class I

Body mass index: BMI = weight (kg)/height (m)², with the height converted to metres first. With pounds and inches, BMI = 703 × weight (lb)/height (in)². WHO adult categories: below 18.5 underweight, 18.5–24.9 healthy weight, 25.0–29.9 overweight, 30.0–34.9 obesity class I, 35.0–39.9 obesity class II and 40 or more obesity class III.

BMI

BMI = 120/1.91² = 32.89

Category

obesity class I

Answer

obesity class I
7.Med-surg: cardiovascular & respiratory

Answer: C · They block the platelet ADP (P2Y12) receptor

Why this is the answer

Clopidogrel, prasugrel and ticagrelor block the P2Y12 ADP receptor on platelets, reducing aggregation. With aspirin, they form dual antiplatelet therapy after acute coronary syndromes and stents. Warfarin inhibits vitamin K-dependent factors; dabigatran inhibits thrombin.

Answer

C · They block the platelet ADP (P2Y12) receptor
8.Med-surg: cardiovascular & respiratory

Answer: B · Reduce the oxygen to aim for 88–92% and get a blood gas

Why this is the answer

In patients at risk of hypercapnic respiratory failure, excess oxygen can raise PaCO₂ and cause drowsiness and acidosis. Oxygen is stepped down to a target of 88–92% (for example via a Venturi mask), not stopped abruptly, which could cause dangerous hypoxaemia. An arterial blood gas guides further treatment, which may include NIV.

Answer

B · Reduce the oxygen to aim for 88–92% and get a blood gas

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