Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A size E oxygen cylinder (factor 0.28 L/psi) reads 750 psi and runs at 8 L/min. Keeping a safe residual of 200 psi, how many minutes t will it last? Round down to a whole minute.
750 psif = 0.28 L/psi8 L/min200 psi
t = min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A cylinder with a water capacity of 3 L is filled to 195 bar and runs at 12 L/min. The gas volume is about the water capacity × the pressure. In this exercise the cylinder is changed at 20 bar. How many minutes t until it must be changed? Round down to a whole minute.
3 L195 bar12 L/min20 bar
t = min
3.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.38, PaCO₂ 52 mmHg (6.9 kPa) and HCO₃⁻ 30 mmol/L. The primary disorder is respiratory acidosis. How far is it compensated? Click your answer.
pH 7.38PaCO₂ 52 mmHg (6.9 kPa)HCO₃⁻ 30 mmol/L
1uncompensated
2partially compensated
3fully compensated
4.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.06, PaCO₂ 40 mmHg (5.3 kPa), HCO₃⁻ 11 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.06PaCO₂ 40 mmHg (5.3 kPa)HCO₃⁻ 11 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice patient after a head injury opens the eyes only to pressure (a painful stimulus), says inappropriate, random words and shows as the best motor response: extension of the arms and legs (abnormal extension). Work out the GCS and classify the head injury by it. Click your answer.
1mild
2moderate
3severe
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). At 5 minutes after birth, a practice newborn has blue or pale skin all over, no heartbeat, no response to stimulation, limp limbs with no muscle tone and no breathing. Score the APGAR and click how the score is interpreted.
1reassuring
2moderately abnormal
3low
7.Med-surg: cardiovascular & respiratoryMedium
A patient takes both digoxin and furosemide. Why does the nurse watch the potassium level closely?
ALow potassium makes digoxin stop working completely
BLow potassium increases the risk of digoxin toxicity
CHigh potassium is the main effect of furosemide
DPotassium has no link with either medicine
8.Med-surg: cardiovascular & respiratoryHard
A patient with a confirmed calf DVT has started therapeutic anticoagulation and asks whether they must stay in bed. What is the most accurate answer?
AWalking is not allowed until the clot has fully dissolved
BWalking as tolerated is usually encouraged once treated
CStrict bed rest is needed for at least two weeks
DThe leg should be massaged before each walk
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: t = 19 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(750 − 200)·0.28 = 154 L
Duration
154/8 = 19.25 min → t = 19 min
Answer
t = 19 min
2.Oxygen therapy & respiratory calculations
Answer: t = 43 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable gas
3·(195 − 20) = 525 L
Duration
525/12 = 43.75 min → t = 43 min
Answer
t = 43 min
3.Arterial blood gas interpretation
Answer: fully compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.38: within 7.35–7.45
PaCO₂ 52 mmHg: high (35–45)
HCO₃⁻ 30 mmol/L: high (22–26)
Compensation
fully compensated
Answer
fully compensated
4.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·11 + 8 = 24.5 → 22.5–26.5 mmHg
Compare
measured: 40 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
5.Clinical assessment scores
Answer: severe
Glasgow Coma Scale: add the best response in three areas. Eye opening E: 4 spontaneous, 3 to sound or speech, 2 to pressure, 1 none. Verbal V: 5 oriented, 4 confused, 3 inappropriate words, 2 incomprehensible sounds, 1 none. Motor M: 6 obeys commands, 5 localises, 4 normal flexion (withdraws), 3 abnormal flexion, 2 extension, 1 none. The total runs from 3 to 15. After a head injury, 13–15 is usually called mild, 9–12 moderate and 3–8 severe.
Score each area
E: opens the eyes only to pressure (a painful stimulus) → 2
V: says inappropriate, random words → 3
M: extension of the arms and legs (abnormal extension) → 2
Add
GCS = 2 + 3 + 2 = 7
Severity
GCS 7 → severe
Answer
severe
6.Clinical assessment scores
Answer: low
APGAR score: five signs, each scored 0, 1 or 2, checked at 1 and 5 minutes after birth. Appearance (colour): blue or pale 0, pink body with blue extremities 1, pink all over 2. Pulse: absent 0, below 100/min 1, 100/min or more 2. Grimace (reflex irritability): none 0, grimace 1, cry, cough or sneeze 2. Activity (tone): limp 0, some flexion 1, active movement 2. Respiration: absent 0, slow or irregular with a weak cry 1, good with a strong cry 2. A total of 7–10 is reassuring, 4–6 moderately abnormal and 0–3 low.
Score each sign
Appearance: blue or pale skin all over → 0
Pulse: 0 → 0
Grimace: no response to stimulation → 0
Activity: limp limbs with no muscle tone → 0
Respiration: no breathing → 0
Add
APGAR = 0 + 0 + 0 + 0 + 0 = 0
Interpretation
0 → low
Answer
low
Below 7 at 5 minutes, the score is usually repeated every 5 minutes up to 20 minutes.
7.Med-surg: cardiovascular & respiratory
Answer: B · Low potassium increases the risk of digoxin toxicity
Why this is the answer
Digoxin binds to the Na⁺/K⁺-ATPase pump at the site potassium normally uses. When potassium is low, more digoxin binds, so toxicity and arrhythmias become more likely. Loop diuretics commonly cause hypokalaemia, so the combination needs monitoring.
Answer
B · Low potassium increases the risk of digoxin toxicity
8.Med-surg: cardiovascular & respiratory
Answer: B · Walking as tolerated is usually encouraged once treated
Why this is the answer
Early mobilisation with effective anticoagulation does not increase the risk of pulmonary embolism and may reduce pain, swelling and post-thrombotic syndrome. Routine bed rest is no longer recommended. Massage of the affected leg should be avoided.
Answer
B · Walking as tolerated is usually encouraged once treated