Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A patient has Hb 169 g/L, SaO₂ 98% and PaO₂ 104 mmHg (13.9 kPa). Find the arterial oxygen content CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg) in mL O₂/dL.
Hb 169 g/LSaO₂ 98%PaO₂ 104 mmHg (13.9 kPa)
CaO₂ = mL/dL
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A transfer will take 75 minutes. The size D cylinder (factor 0.16 L/psi) reads 2050 psi. Keeping a safe residual of 200 psi, what is the highest whole-number flow Q in L/min that lasts the whole transfer?
75 min2050 psif = 0.16 L/psi200 psi
Q = L/min
3.Arterial blood gas interpretationMedium
A practice arterial blood gas shows pH 7.27, PaCO₂ 70 mmHg (9.3 kPa) and HCO₃⁻ 31 mmol/L. The primary disorder is respiratory acidosis. How far is it compensated? Click your answer.
pH 7.27PaCO₂ 70 mmHg (9.3 kPa)HCO₃⁻ 31 mmol/L
1uncompensated
2partially compensated
3fully compensated
4.Arterial blood gas interpretationHard
A practice gas shows a metabolic alkalosis with HCO₃⁻ 39 mmol/L. Use expected PaCO₂ = 0.7·HCO₃⁻ + 21 to find the expected PaCO₂.
HCO₃⁻ 39 mmol/L
PaCO₂ = mmHg
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). Use the NEWS2 chart (SpO₂ scale 1) for these observations: respiration rate 16/min, SpO₂ 97% on supplemental oxygen, blood pressure 84/50 mmHg, pulse 44/min, alert, temperature 36.2 °C. What is the NEWS2 total score?
RR 16SpO₂ 97%O₂SBP 84HR 44AT 36.2 °C
NEWS2 =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). An adult weighs 114 kg and is 182 cm tall. Calculate the BMI and click the WHO weight category.
114 kg182 cm
1underweight
2healthy weight
3overweight
4obesity class I
5obesity class II
6obesity class III
7.Med-surg: cardiovascular & respiratoryMedium
What is the main difference between CPAP and bilevel NIV (often called BiPAP)?
ABilevel NIV gives oxygen only, without any positive airway pressure
BCPAP is given only through a tracheostomy
CBilevel NIV adds a higher inspiratory pressure, helping remove CO₂
DCPAP is mainly used to lower a raised PaCO₂ in COPD exacerbations
8.Med-surg: cardiovascular & respiratoryHard
Two days after a coronary stent, a patient on aspirin and ticagrelor has black, tarry stools and feels faint on standing. What should the nurse do?
AGive a laxative and repeat the observations tomorrow
BStop both antiplatelet drugs permanently on the nurse's own decision
CReassure the patient that iron tablets cause black stools
DCheck vital signs, report urgently and anticipate a blood count
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: CaO₂ = 22.51 mL/dL
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Hb in g/dL
169 g/L = 16.9 g/dL
Bound oxygen
1.34·16.9·0.98 = 22.19 mL/dL
Dissolved oxygen
0.003·104 = 0.312 mL/dL
Oxygen content
CaO₂ = 22.19 + 0.312 = 22.51 mL/dL
Answer
CaO₂ = 22.51 mL/dL
2.Oxygen therapy & respiratory calculations
Answer: Q = 3 L/min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(2050 − 200)·0.16 = 296 L
Highest flow
296/75 = 3.947 L/min → Q = 3 L/min
Answer
Q = 3 L/min
3.Arterial blood gas interpretation
Answer: partially compensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.27: acidaemia (below 7.35)
PaCO₂ 70 mmHg: high (35–45)
HCO₃⁻ 31 mmol/L: high (22–26)
Compensation
partially compensated
Answer
partially compensated
4.Arterial blood gas interpretation
Answer: PaCO₂ = 48.3 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
0.7·39 + 21 = 48.3 mmHg
Answer
PaCO₂ = 48.3 mmHg
The rise has a limit: PaCO₂ rarely goes above about 55 mmHg from compensation alone.
5.Clinical assessment scores
Answer: NEWS2 = 6
NEWS2 (National Early Warning Score 2, Royal College of Physicians 2017): score each of the seven parameters with the chart (respiration rate, SpO₂ on scale 1, air or supplemental oxygen, systolic blood pressure, pulse, consciousness on the ACVPU scale and temperature) and add the scores. Clinical risk: 0–4 low; a score of 3 in any single parameter low–medium; 5–6 medium; 7 or more high. A total of 5 or more needs an urgent response.
Score each parameter
RR 16/min → 0
SpO₂ 97% → 0
on oxygen → 2
SBP 84 mmHg → 3
HR 44/min → 1
alert (A) → 0
T 36.2 °C → 0
Add
NEWS2 = 0 + 0 + 2 + 3 + 1 + 0 + 0 = 6
Answer
NEWS2 = 6
6.Clinical assessment scores
Answer: obesity class I
Body mass index: BMI = weight (kg)/height (m)², with the height converted to metres first. With pounds and inches, BMI = 703 × weight (lb)/height (in)². WHO adult categories: below 18.5 underweight, 18.5–24.9 healthy weight, 25.0–29.9 overweight, 30.0–34.9 obesity class I, 35.0–39.9 obesity class II and 40 or more obesity class III.
BMI
BMI = 114/1.82² = 34.42
Category
obesity class I
Answer
obesity class I
7.Med-surg: cardiovascular & respiratory
Answer: C · Bilevel NIV adds a higher inspiratory pressure, helping remove CO₂
Why this is the answer
CPAP gives one continuous pressure that splints the airways and alveoli open, improving oxygenation (for example in pulmonary oedema or OSA). Bilevel NIV adds a higher inspiratory pressure that supports ventilation, so it is used for hypercapnic respiratory failure such as COPD exacerbations.
Answer
C · Bilevel NIV adds a higher inspiratory pressure, helping remove CO₂
8.Med-surg: cardiovascular & respiratory
Answer: D · Check vital signs, report urgently and anticipate a blood count
Why this is the answer
Melaena with postural dizziness suggests upper gastrointestinal bleeding, a risk with dual antiplatelet therapy. The nurse assesses for shock, informs the team urgently and expects bloods, a group and save (type and screen) and possibly endoscopy. Stopping antiplatelets after a stent risks stent thrombosis, so the decision belongs to the medical and cardiology team.
Answer
D · Check vital signs, report urgently and anticipate a blood count