Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A patient has Hb 137 g/L, SaO₂ 97% and PaO₂ 86 mmHg (11.5 kPa). Find the arterial oxygen content CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg) in mL O₂/dL.
Hb 137 g/LSaO₂ 97%PaO₂ 86 mmHg (11.5 kPa)
CaO₂ = mL/dL
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A patient has Hb 124 g/L, SaO₂ 95%, PaO₂ 76 mmHg (10.1 kPa) and a cardiac output of 6.4 L/min. With CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), find the oxygen delivery DO₂ = CaO₂ × CO × 10 in mL/min.
A practice gas shows PaCO₂ 22 mmHg (2.9 kPa). Use the rule that in chronic respiratory alkalosis HCO₃⁻ falls by 5 mmol/L for every 10 mmHg that PaCO₂ is below 40, starting from HCO₃⁻ 24 mmol/L, to find the expected HCO₃⁻.
Practice exercise (made-up values, not clinical guidance). Use the NEWS2 chart (SpO₂ scale 1) for these observations: respiration rate 11/min, SpO₂ 95% on room air, blood pressure 106/64 mmHg, pulse 76/min, alert, temperature 35.0 °C. What is the NEWS2 total score?
RR 11SpO₂ 95%airSBP 106HR 76AT 35.0 °C
NEWS2 =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). An adult weighs 112 kg and is 173 cm tall. Calculate the BMI and click the WHO weight category.
112 kg173 cm
1underweight
2healthy weight
3overweight
4obesity class I
5obesity class II
6obesity class III
7.Med-surg: cardiovascular & respiratoryMedium
A patient on furosemide has a serum potassium of 3.0 mmol/L (3.0 mEq/L). Which symptoms may this cause?
ATingling around the lips and painful spasm of the hands
BFacial flushing, fever and a skin rash
CSevere headache and a stiff neck
DMuscle weakness, cramps and an irregular pulse
8.Med-surg: cardiovascular & respiratoryHard
A woman starting rifampicin (rifampin) for tuberculosis uses a combined oral contraceptive pill. What advice is correct?
AUse another reliable method, as rifampicin reduces the pill's effect
BStop all contraception during TB treatment, as pregnancy cannot occur
CContinue the pill as usual, because there is no interaction with TB drugs
DTake two pills a day to make up for the drug
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: CaO₂ = 18.07 mL/dL
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Hb in g/dL
137 g/L = 13.7 g/dL
Bound oxygen
1.34·13.7·0.97 = 17.81 mL/dL
Dissolved oxygen
0.003·86 = 0.258 mL/dL
Oxygen content
CaO₂ = 17.81 + 0.258 = 18.07 mL/dL
Answer
CaO₂ = 18.07 mL/dL
2.Oxygen therapy & respiratory calculations
Answer: DO₂ = 1025 mL/min
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Oxygen content
124 g/L = 12.4 g/dL
CaO₂ = 1.34·12.4·0.95 + 0.003·76 = 16.01 mL/dL
Oxygen delivery
DO₂ = 16.01·6.4·10 = 1025 mL/min
Answer
DO₂ = 1025 mL/min
A normal resting adult value is about 1000 mL/min.
3.Arterial blood gas interpretation
Answer: HCO₃⁻ = 15 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Change in PaCO₂
|22 − 40| = 18 mmHg → 1.8 × 10 mmHg
Expected HCO₃⁻
HCO₃⁻ = 24 − 5·1.8 = 15 mmol/L
Answer
HCO₃⁻ = 15 mmol/L
4.Arterial blood gas interpretation
Answer: AGc = 18.75 mmol/L
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Anion gap
AG = 141 − (106 + 18) = 17
Correction for albumin
17 + 0.25·(40 − 33) = 18.75 mmol/L
Answer
AGc = 18.75 mmol/L
Above about 12 after correction: a high anion gap.
5.Clinical assessment scores
Answer: NEWS2 = 6
NEWS2 (National Early Warning Score 2, Royal College of Physicians 2017): score each of the seven parameters with the chart (respiration rate, SpO₂ on scale 1, air or supplemental oxygen, systolic blood pressure, pulse, consciousness on the ACVPU scale and temperature) and add the scores. Clinical risk: 0–4 low; a score of 3 in any single parameter low–medium; 5–6 medium; 7 or more high. A total of 5 or more needs an urgent response.
Score each parameter
RR 11/min → 1
SpO₂ 95% → 1
on air → 0
SBP 106 mmHg → 1
HR 76/min → 0
alert (A) → 0
T 35.0 °C → 3
Add
NEWS2 = 1 + 1 + 0 + 1 + 0 + 0 + 3 = 6
Answer
NEWS2 = 6
6.Clinical assessment scores
Answer: obesity class II
Body mass index: BMI = weight (kg)/height (m)², with the height converted to metres first. With pounds and inches, BMI = 703 × weight (lb)/height (in)². WHO adult categories: below 18.5 underweight, 18.5–24.9 healthy weight, 25.0–29.9 overweight, 30.0–34.9 obesity class I, 35.0–39.9 obesity class II and 40 or more obesity class III.
BMI
BMI = 112/1.73² = 37.42
Category
obesity class II
Answer
obesity class II
7.Med-surg: cardiovascular & respiratory
Answer: D · Muscle weakness, cramps and an irregular pulse
Why this is the answer
The adult reference range is about 3.5–5.0 mmol/L, so 3.0 mmol/L is low. Hypokalaemia causes weakness, cramps, constipation and arrhythmias, with flattened T waves and U waves on the ECG. Tingling lips and hand spasm suggest low calcium.
Answer
D · Muscle weakness, cramps and an irregular pulse
8.Med-surg: cardiovascular & respiratory
Answer: A · Use another reliable method, as rifampicin reduces the pill's effect
Why this is the answer
Rifampicin induces liver enzymes that break down oestrogen and progestogen, so hormonal contraception may fail. A non-hormonal or unaffected method, such as a copper IUD, is advised during and for a time after treatment. The interaction also affects warfarin and many other drugs.
Answer
A · Use another reliable method, as rifampicin reduces the pill's effect