Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A ventilated patient who meets the other Berlin criteria for ARDS has PaO₂ 128 mmHg (17.1 kPa) on 30% oxygen with a PEEP of 6 cmH₂O. Calculate the P/F ratio and click the ARDS severity.
PaO₂ 128 mmHg (17.1 kPa)FiO₂ 30%PEEP 6 cmH₂O
1above 300
2mild
3moderate
4severe
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A patient has Hb 92 g/L, SaO₂ 95%, PaO₂ 75 mmHg (10.0 kPa) and a cardiac output of 6.8 L/min. With CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), find the oxygen delivery DO₂ = CaO₂ × CO × 10 in mL/min.
A practice arterial blood gas shows pH 7.12, PaCO₂ 77 mmHg (10.3 kPa) and HCO₃⁻ 24 mmol/L. The primary disorder is respiratory acidosis. How far is it compensated? Click your answer.
pH 7.12PaCO₂ 77 mmHg (10.3 kPa)HCO₃⁻ 24 mmol/L
1uncompensated
2partially compensated
3fully compensated
4.Arterial blood gas interpretationHard
A practice gas shows a respiratory acidosis: pH 7.26, PaCO₂ 74 mmHg (9.9 kPa), HCO₃⁻ 32 mmol/L. Use the rules ‘HCO₃⁻ rises 1 mmol/L per 10 mmHg (acute) or 3.5 mmol/L per 10 mmHg (chronic)’ to classify it. Click your answer.
pH 7.26PaCO₂ 74 mmHg (9.9 kPa)HCO₃⁻ 32 mmol/L
1acute
2chronic
3acute on chronic
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice chart records GCS 9, with E2 and V3. What motor score M was recorded, and which response does it describe? Give the number.
GCS 9E2V3
M =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). At 1 minute after birth, a practice newborn has a pink body with blue hands and feet, a heart rate of 140/min, a grimace when stimulated, some flexion of the arms and legs and good breathing with a strong cry. Score the APGAR and click how the score is interpreted.
1reassuring
2moderately abnormal
3low
7.Med-surg: cardiovascular & respiratoryMedium
A patient with chest pain asks for glyceryl trinitrate. Which information means the nurse should withhold it and contact the prescriber?
AThe patient took sildenafil earlier today
BThe patient takes a daily statin
CThe patient had a headache last week
DThe patient's blood pressure is 150/90 mmHg
8.Med-surg: cardiovascular & respiratoryHard
A patient taking ramipril and indapamide for hypertension starts regular ibuprofen for back pain. A week later, creatinine has risen sharply. What is the most likely cause?
AAn ACE inhibitor, diuretic and NSAID together reducing kidney perfusion
BIbuprofen raising the blood pressure to levels that damage the kidneys
CAn allergic reaction to the diuretic causing inflammation of the kidney
DBack pain causing kidney damage
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: above 300
P/F ratio and ARDS (Berlin definition): P/F = PaO₂ (mmHg)/FiO₂ (as a fraction). With PEEP or CPAP of at least 5 cmH₂O, ARDS is graded mild for 200 < P/F ≤ 300, moderate for 100 < P/F ≤ 200 and severe for P/F ≤ 100 mmHg. The other Berlin criteria (onset within a week, bilateral opacities, not fully explained by heart failure) must also be met. PaO₂ in kPa × 7.5 gives mmHg. The ROX index (SpO₂/FiO₂)/respiratory rate is used to follow patients on high-flow nasal oxygen.
P/F ratio
P/F = 128/0.3 = 426.7 mmHg
Berlin severity
above 300
Answer
above 300
2.Oxygen therapy & respiratory calculations
Answer: DO₂ = 811.7 mL/min
Oxygen content and delivery: CaO₂ = 1.34 × Hb (g/dL) × SaO₂ + 0.003 × PaO₂ (mmHg), in mL O₂ per dL of blood, with SaO₂ as a fraction. Almost all oxygen is bound to haemoglobin; the dissolved part is small. Delivery DO₂ = CaO₂ × cardiac output (L/min) × 10 (mL/min), because 1 L = 10 dL; a normal resting adult value is about 1000 mL/min.
Oxygen content
92 g/L = 9.2 g/dL
CaO₂ = 1.34·9.2·0.95 + 0.003·75 = 11.94 mL/dL
Oxygen delivery
DO₂ = 11.94·6.8·10 = 811.7 mL/min
Answer
DO₂ = 811.7 mL/min
A normal resting adult value is about 1000 mL/min.
3.Arterial blood gas interpretation
Answer: uncompensated
Reading a blood gas (ROME): first the pH: below 7.35 is acidaemia, above 7.45 alkalaemia. Then find the value that explains it. PaCO₂ (normal 35–45 mmHg, 4.7–6.0 kPa) is the respiratory part and moves Opposite to the pH in a respiratory disorder; HCO₃⁻ (normal 22–26 mmol/L) is the metabolic part and moves in the same direction as the pH (Respiratory Opposite, Metabolic Equal). The other value shows the compensation: normal means uncompensated; abnormal in the direction that pulls the pH back while the pH is still abnormal means partially compensated; a normal pH with both values abnormal means fully compensated. Ranges differ slightly between laboratories; these are practice values.
ROME, value by value
pH 7.12: acidaemia (below 7.35)
PaCO₂ 77 mmHg: high (35–45)
HCO₃⁻ 24 mmol/L: normal (22–26)
Compensation
uncompensated
Answer
uncompensated
4.Arterial blood gas interpretation
Answer: acute on chronic
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected HCO₃⁻
acute: 24 + 1·3.4 = 27.4 mmol/L
chronic: 24 + 3.5·3.4 = 35.9 mmol/L
Compare
measured: 32 mmol/L → acute on chronic
Answer
acute on chronic
5.Clinical assessment scores
Answer: M = 4
Glasgow Coma Scale: add the best response in three areas. Eye opening E: 4 spontaneous, 3 to sound or speech, 2 to pressure, 1 none. Verbal V: 5 oriented, 4 confused, 3 inappropriate words, 2 incomprehensible sounds, 1 none. Motor M: 6 obeys commands, 5 localises, 4 normal flexion (withdraws), 3 abnormal flexion, 2 extension, 1 none. The total runs from 3 to 15. After a head injury, 13–15 is usually called mild, 9–12 moderate and 3–8 severe.
Motor score
M = 9 − 2 − 3 = 4
M4: withdraws the limb from pressure (normal flexion)
Answer
M = 4
6.Clinical assessment scores
Answer: reassuring
APGAR score: five signs, each scored 0, 1 or 2, checked at 1 and 5 minutes after birth. Appearance (colour): blue or pale 0, pink body with blue extremities 1, pink all over 2. Pulse: absent 0, below 100/min 1, 100/min or more 2. Grimace (reflex irritability): none 0, grimace 1, cry, cough or sneeze 2. Activity (tone): limp 0, some flexion 1, active movement 2. Respiration: absent 0, slow or irregular with a weak cry 1, good with a strong cry 2. A total of 7–10 is reassuring, 4–6 moderately abnormal and 0–3 low.
Score each sign
Appearance: a pink body with blue hands and feet → 1
Pulse: 140/min → 2
Grimace: a grimace when stimulated → 1
Activity: some flexion of the arms and legs → 1
Respiration: good breathing with a strong cry → 2
Add
APGAR = 1 + 2 + 1 + 1 + 2 = 7
Interpretation
7 → reassuring
Answer
reassuring
7.Med-surg: cardiovascular & respiratory
Answer: A · The patient took sildenafil earlier today
Why this is the answer
Phosphodiesterase-5 inhibitors such as sildenafil (within about 24 hours) or tadalafil (within about 48 hours) combined with nitrates can cause severe, life-threatening hypotension. Nitrates are also avoided with a systolic pressure below about 90 mmHg.
Answer
A · The patient took sildenafil earlier today
8.Med-surg: cardiovascular & respiratory
Answer: A · An ACE inhibitor, diuretic and NSAID together reducing kidney perfusion
Why this is the answer
NSAIDs constrict the afferent arteriole, ACE inhibitors dilate the efferent arteriole and diuretics reduce volume. Together (sometimes called the "triple whammy") they can cause acute kidney injury. The NSAID is stopped, and the prescriber reviews the other drugs.
Answer
A · An ACE inhibitor, diuretic and NSAID together reducing kidney perfusion