Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A size D oxygen cylinder (factor 0.16 L/psi) reads 1350 psi and runs at 6 L/min. Keeping a safe residual of 200 psi, how many minutes t will it last? Round down to a whole minute.
1350 psif = 0.16 L/psi6 L/min200 psi
t = min
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A patient with acute hypoxaemia and bilateral opacities, not explained by heart failure, has PaO₂ 14.2 kPa on 40% oxygen with a PEEP of 10 cmH₂O. Grade the ARDS severity with the Berlin definition. Click your answer.
PaO₂ 14.2 kPaFiO₂ 40%PEEP 10 cmH₂O
1above 300: no ARDS grade
2mild
3moderate
4severe
5not gradable: PEEP below 5
3.Arterial blood gas interpretationMedium
Practice values: Na⁺ 145 mmol/L, glucose 26.4 mmol/L and urea 5 mmol/L. Calculate the serum osmolality Osm = 2·Na⁺ + glucose + urea to the nearest whole number.
Na⁺ 145 mmol/Lglucose 26.4 mmol/Lurea 5 mmol/L
Osm = mOsm/kg
4.Arterial blood gas interpretationHard
A practice gas shows a metabolic acidosis: pH 7.13, PaCO₂ 34 mmHg (4.5 kPa), HCO₃⁻ 11 mmol/L. Compare the measured PaCO₂ with Winter’s formula. Click your interpretation.
pH 7.13PaCO₂ 34 mmHg (4.5 kPa)HCO₃⁻ 11 mmol/L
1appropriate compensation
2added respiratory acidosis
3added respiratory alkalosis
5.Clinical assessment scoresMedium
Practice exercise (made-up values, not clinical guidance). A practice patient is assessed with the Morse fall scale: history of falling in the last 3 months: yes; secondary diagnosis: yes; ambulatory aid: crutches, cane or walker; IV therapy or saline lock: no; gait: weak; mental status: overestimates or forgets limits. Find the Morse total MFS.
0–125
MFS =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). The team aims for a mean arterial pressure of at least 60 mmHg. A patient’s systolic pressure is 92 mmHg. Using MAP = (SBP + 2·DBP)/3, what is the lowest diastolic pressure DBP that still gives a MAP of 60 mmHg?
MAP 60 mmHgSBP 92 mmHg
DBP = mmHg
7.Med-surg: cardiovascular & respiratoryMedium
Why should a simple face mask not be used with an oxygen flow below about 5 L/min?
AThe mask delivers too much oxygen at low flows
BOxygen cannot be humidified at low flows
CThe elastic strap is too loose at low flows
DExhaled CO₂ can collect in the mask and be rebreathed
8.Med-surg: cardiovascular & respiratoryHard
Four hours after PCI via the femoral artery, the groin dressing is soaked with blood and a firm swelling is growing. What is the immediate action?
AApply firm pressure just above the puncture site and call for help
BIncrease the heparin infusion rate so that no clot forms at the site
CRemove the dressing and leave the site open to the air
DHelp the patient sit up and walk to the toilet to void
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: t = 30 min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(1350 − 200)·0.16 = 184 L
Duration
184/6 = 30.67 min → t = 30 min
Answer
t = 30 min
2.Oxygen therapy & respiratory calculations
Answer: mild
P/F ratio and ARDS (Berlin definition): P/F = PaO₂ (mmHg)/FiO₂ (as a fraction). With PEEP or CPAP of at least 5 cmH₂O, ARDS is graded mild for 200 < P/F ≤ 300, moderate for 100 < P/F ≤ 200 and severe for P/F ≤ 100 mmHg. The other Berlin criteria (onset within a week, bilateral opacities, not fully explained by heart failure) must also be met. PaO₂ in kPa × 7.5 gives mmHg. The ROX index (SpO₂/FiO₂)/respiratory rate is used to follow patients on high-flow nasal oxygen.
PEEP
PEEP 10 ≥ 5 cmH₂O
PaO₂ in mmHg
14.2·7.5 = 106.5 mmHg
P/F ratio
P/F = 106.5/0.4 = 266.3 mmHg
Berlin severity
mild
Answer
mild
3.Arterial blood gas interpretation
Answer: Osm = 321 mOsm/kg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Calculated osmolality
Osm = 2·145 + 26.4 + 5 = 321.4 ≈ 321 mOsm/kg
Answer
Osm = 321 mOsm/kg
4.Arterial blood gas interpretation
Answer: added respiratory acidosis
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Expected PaCO₂
1.5·11 + 8 = 24.5 → 22.5–26.5 mmHg
Compare
measured: 34 mmHg → added respiratory acidosis
Answer
added respiratory acidosis
5.Clinical assessment scores
Answer: MFS = 80
Morse fall scale: six items. History of falling: no 0, yes 25. Secondary diagnosis: no 0, yes 15. Ambulatory aid: none, bed rest or nurse assistance 0; crutches, cane or walker 15; holding on to furniture 30. IV therapy or saline lock: no 0, yes 20. Gait: normal, bed rest or wheelchair 0; weak 10; impaired 20. Mental status: knows own limits 0; overestimates or forgets limits 15. The total runs from 0 to 125. Risk cut-offs differ between hospitals; a common set is 0–24 low, 25–44 moderate and 45 or more high.
Score each item
history of falling in the last 3 months: yes → 25
secondary diagnosis: yes → 15
ambulatory aid: crutches, cane or walker → 15
IV therapy or saline lock: no → 0
gait: weak → 10
mental status: overestimates or forgets limits → 15
Add
Morse total = 25 + 15 + 15 + 0 + 10 + 15 = 80
Answer
MFS = 80
6.Clinical assessment scores
Answer: DBP = 44 mmHg
Blood pressure values: pulse pressure PP = SBP − DBP. Mean arterial pressure MAP ≈ (SBP + 2·DBP)/3 = DBP + PP/3, an estimate based on the heart spending about two thirds of each beat in diastole at a normal heart rate (less accurate when the heart rate is fast); a MAP of at least about 65 mmHg is a common target for organ perfusion. The shock index SI = heart rate/SBP is normally about 0.5–0.7; a value above about 1 is a warning sign of shock.
Rearrange
DBP = (3·MAP − SBP)/2
Substitute
DBP = (3·60 − 92)/2 = 88/2 = 44 mmHg
Answer
DBP = 44 mmHg
7.Med-surg: cardiovascular & respiratory
Answer: D · Exhaled CO₂ can collect in the mask and be rebreathed
Why this is the answer
Simple face masks need about 5–10 L/min to wash exhaled CO₂ out of the mask. At lower flows the patient may rebreathe CO₂; a nasal cannula is more appropriate for low flows.
Answer
D · Exhaled CO₂ can collect in the mask and be rebreathed
8.Med-surg: cardiovascular & respiratory
Answer: A · Apply firm pressure just above the puncture site and call for help
Why this is the answer
Bleeding or haematoma at the arterial access site is a common complication, made worse by antiplatelet and anticoagulant drugs. Firm manual pressure just above the skin puncture (over the arterial puncture), with the patient lying flat, is the first action, together with vital signs, distal pulses and escalation. Retroperitoneal bleeding can be hidden, so watch for back pain and hypotension.
Answer
A · Apply firm pressure just above the puncture site and call for help