Read the pH: below 7.35 is acidosis, above 7.45 alkalosis.
Find the value that explains it: PaCO₂ moving opposite to the pH is respiratory, HCO₃⁻ moving with the pH is metabolic.
Look at the other value: normal means uncompensated, abnormal in the compensating direction means partial compensation, and a normal pH with both abnormal means full compensation.
In a metabolic acidosis, compare PaCO₂ with Winter’s formula, 1.5·HCO₃⁻ + 8 ± 2, and calculate the anion gap Na⁺ − (Cl⁻ + HCO₃⁻).
Check a high anion gap with the delta ratio and, when albumin is low, with the corrected gap.
falls 25, diagnosis 15, aid 15/30, IV 20, gait 10/20, mental status 15
NEWS2 risk
0–4 low; single 3 low–medium; 5–6 medium; ≥ 7 high
Mean arterial pressure
MAP = (SBP + 2·DBP)/3 = DBP + PP/3
Pulse pressure and shock index
PP = SBP − DBP, SI = HR/SBP
Body mass index
BMI = kg/m² = 703·lb/in²
Method
Find the score sheet that the question uses and its range (GCS 3–15, APGAR 0–10, Braden 6–23, Morse 0–125).
Score every item separately, matching the description to its level.
Add the item scores and check that the total lies inside the range.
Apply the cut-offs: for NEWS2 also look for any single parameter scoring 3.
For derived values use MAP = (SBP + 2·DBP)/3, PP = SBP − DBP, SI = HR/SBP and BMI = kg/m².
Med-surg: cardiovascular & respiratory
Method
Name the problem: pump failure, blocked artery, rhythm, clot, airway narrowing, infection or a device problem.
Check the danger signs first: hypoxia, hypotension, chest pain, new confusion, a cold pulseless limb.
Match the oxygen to the patient: 94–98% for most, 88–92% for those at risk of CO₂ retention.
Link each drug to its test and its risk: warfarin and INR, heparin and aPTT and platelets, diuretics and potassium.
Choose the safe first action, then escalate and reassess.
2Practice problems
1.Oxygen therapy & respiratory calculationsMedium
Practice exercise (made-up values, not clinical guidance). A ventilated patient who meets the other Berlin criteria for ARDS has PaO₂ 106 mmHg (14.1 kPa) on 80% oxygen with a PEEP of 6 cmH₂O. Calculate the P/F ratio and click the ARDS severity.
PaO₂ 106 mmHg (14.1 kPa)FiO₂ 80%PEEP 6 cmH₂O
1above 300
2mild
3moderate
4severe
2.Oxygen therapy & respiratory calculationsHard
Practice exercise (made-up values, not clinical guidance). A transfer will take 120 minutes. The size E cylinder (factor 0.28 L/psi) reads 1000 psi. Keeping a safe residual of 200 psi, what is the highest whole-number flow Q in L/min that lasts the whole transfer?
120 min1000 psif = 0.28 L/psi200 psi
Q = L/min
3.Arterial blood gas interpretationMedium
A practice gas shows a metabolic acidosis with HCO₃⁻ 16 mmol/L. Use Winter’s formula to find the expected PaCO₂ (the centre of the range) in mmHg.
HCO₃⁻ 16 mmol/L
PaCO₂ = mmHg
4.Arterial blood gas interpretationHard
At sea level, a practice gas taken on 21% oxygen shows PaO₂ 77 mmHg (10.3 kPa) and PaCO₂ 34 mmHg (4.5 kPa). Use PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 to find the A–a gradient.
Practice exercise (made-up values, not clinical guidance). A practice patient is assessed with the Braden scale: sensory perception: completely limited; moisture: very moist; activity: walks frequently; mobility: slightly limited; nutrition: excellent; friction and shear: problem. Find the Braden total B.
6–23
B =
6.Clinical assessment scoresHard
Practice exercise (made-up values, not clinical guidance). Use the NEWS2 chart (SpO₂ scale 1) for these observations: respiration rate 18/min, SpO₂ 97% on room air, blood pressure 124/74 mmHg, pulse 140/min, alert, temperature 37.0 °C. Which clinical risk group does the patient fall into? Click it.
RR 18SpO₂ 97%airSBP 124HR 140AT 37.0 °C
1low
2low–medium
3medium
4high
7.Med-surg: cardiovascular & respiratoryMedium
A patient with a long QT interval develops a polymorphic ventricular tachycardia that twists around the baseline but still has a pulse. Which drug is used first?
AIntravenous potassium chloride as a bolus
BOral digoxin
CIntravenous magnesium sulfate
DIntravenous adenosine
8.Med-surg: cardiovascular & respiratoryHard
A nurse reviews inhaler use with a patient who has asthma and uses a separate steroid preventer inhaler and a salbutamol reliever. Which statement shows a need for further teaching?
A"I rinse my mouth after the steroid inhaler."
B"I use my steroid inhaler when I start to wheeze."
C"I use my steroid inhaler every day, even when I feel well."
D"I carry my blue reliever inhaler with me."
3Solutions
1.Oxygen therapy & respiratory calculations
Answer: moderate
P/F ratio and ARDS (Berlin definition): P/F = PaO₂ (mmHg)/FiO₂ (as a fraction). With PEEP or CPAP of at least 5 cmH₂O, ARDS is graded mild for 200 < P/F ≤ 300, moderate for 100 < P/F ≤ 200 and severe for P/F ≤ 100 mmHg. The other Berlin criteria (onset within a week, bilateral opacities, not fully explained by heart failure) must also be met. PaO₂ in kPa × 7.5 gives mmHg. The ROX index (SpO₂/FiO₂)/respiratory rate is used to follow patients on high-flow nasal oxygen.
P/F ratio
P/F = 106/0.8 = 132.5 mmHg
Berlin severity
moderate
Answer
moderate
2.Oxygen therapy & respiratory calculations
Answer: Q = 1 L/min
Cylinder duration: usable litres = (gauge pressure − safe residual) × cylinder factor, with the safe residual usually 200 psi. Cylinder factors in L/psi: D 0.16, E 0.28, H (and K) 3.14. Duration (min) = usable litres/flow (L/min). Round a duration down, never up, so the cylinder is changed in time. In bar-based systems, the gas volume is the water capacity (L) × the pressure (bar).
Usable litres
(1000 − 200)·0.28 = 224 L
Highest flow
224/120 = 1.867 L/min → Q = 1 L/min
Answer
Q = 1 L/min
3.Arterial blood gas interpretation
Answer: PaCO₂ = 32 mmHg
Expected compensation: in metabolic acidosis Winter’s formula predicts PaCO₂ = 1.5·HCO₃⁻ + 8 ± 2 mmHg; a measured value above that range points to an additional respiratory acidosis, below it to an additional respiratory alkalosis. The anion gap AG = Na⁺ − (Cl⁻ + HCO₃⁻), normally about 8–12 mmol/L, separates high-gap from normal-gap metabolic acidosis; low albumin hides a high gap (add 2.5 per g/dL that albumin is below 4.0). The delta ratio (AG − 12)/(24 − HCO₃⁻) between about 0.8 and 2 fits a pure high-gap acidosis (some texts use 1 instead of 0.8), below that an added normal-gap acidosis, and above 2 an added metabolic alkalosis.
Winter’s formula
PaCO₂ = 1.5·16 + 8 = 32 mmHg
range: 30–34 mmHg
Answer
PaCO₂ = 32 mmHg
4.Arterial blood gas interpretation
Answer: A–a gradient = 30.23 mmHg
Derived values: calculated serum osmolality is 2·Na⁺ + glucose + urea with all values in mmol/L (2·Na⁺ + glucose/18 + BUN/2.8 with glucose and BUN in mg/dL); normal is about 275–295 mOsm/kg. The P/F ratio is PaO₂ divided by FiO₂ as a fraction. The alveolar oxygen pressure is PAO₂ = FiO₂·(760 − 47) − PaCO₂/0.8 mmHg at sea level, and the A–a gradient is PAO₂ − PaO₂.
Braden scale: six subscales for pressure-injury risk. Sensory perception, moisture, activity, mobility and nutrition score 1 to 4, from the worst level (1) to no problem (4); friction and shear scores 1 to 3. The total runs from 6 to 23, and a lower total means a higher risk. Common bands: 19–23 not at risk, 15–18 mild risk, 13–14 moderate risk, 10–12 high risk and 9 or below very high risk.
Score each subscale
sensory perception: completely limited → 1
moisture: very moist → 2
activity: walks frequently → 4
mobility: slightly limited → 3
nutrition: excellent → 4
friction and shear: problem → 1
Add
Braden total = 1 + 2 + 4 + 3 + 4 + 1 = 15
Answer
B = 15
6.Clinical assessment scores
Answer: low–medium
NEWS2 (National Early Warning Score 2, Royal College of Physicians 2017): score each of the seven parameters with the chart (respiration rate, SpO₂ on scale 1, air or supplemental oxygen, systolic blood pressure, pulse, consciousness on the ACVPU scale and temperature) and add the scores. Clinical risk: 0–4 low; a score of 3 in any single parameter low–medium; 5–6 medium; 7 or more high. A total of 5 or more needs an urgent response.
Score each parameter
RR 18/min → 0
SpO₂ 97% → 0
on air → 0
SBP 124 mmHg → 0
HR 140/min → 3
alert (A) → 0
T 37.0 °C → 0
Total and red scores
NEWS2 = 0 + 0 + 0 + 0 + 3 + 0 + 0 = 3
At least one parameter scores 3.
Risk group
low–medium
Answer
low–medium
A single score of 3 needs an urgent review even when the total is low.
7.Med-surg: cardiovascular & respiratory
Answer: C · Intravenous magnesium sulfate
Why this is the answer
Torsades de pointes is treated with IV magnesium, plus correction of low potassium and stopping drugs that prolong the QT interval. If the patient loses their pulse, defibrillation is needed. Potassium must never be given as an IV bolus.
Answer
C · Intravenous magnesium sulfate
8.Med-surg: cardiovascular & respiratory
Answer: B · "I use my steroid inhaler when I start to wheeze."
Why this is the answer
Inhaled corticosteroids are preventers that reduce airway inflammation over days to weeks and must be taken regularly. They do not relieve an acute wheeze. Unless the patient has a combined reliever and maintenance regimen, a short-acting bronchodilator is used for symptoms.
Answer
B · "I use my steroid inhaler when I start to wheeze."