Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of vancomycin, which has a half-life of 12 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 6 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 3 h later?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 140 mg of gentamicin. The level back-extrapolated to time zero is 6 mg/L and the half-life is 3 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 800 mL/min. What infusion rate R in mg/min keeps the steady-state level at 2.5 mg/L?
Practice exercise (made-up values, not clinical guidance). A 93 kg patient has a phenytoin level of 12 mg/L; the target is 20 mg/L. The drug is given intravenously as phenytoin sodium (S = 0.92), and the volume of distribution is 0.7 L/kg. What extra loading dose LD raises the level to the target?
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 100 mg/h with no loading dose. The patient's clearance is 5 L/h and the half-life is 8 h. What is the level C after 4 h?
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