Practice exercise (made-up values, not clinical guidance). A patient who weighs 78 kg needs a loading dose of vancomycin to reach a level of 25 mg/L straight away. The volume of distribution is 0.7 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient who weighs 60 kg needs a loading dose of theophylline to reach a level of 12 mg/L straight away. The volume of distribution is 0.5 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 10 mg/L at 1 h and 3.5 mg/L at 4 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A 96 kg patient receives a theophylline infusion. The clearance is 0.04 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 12 mg/L?
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin IV every 12 h; the vancomycin clearance is 3 L/h. What dose D in mg gives an average steady-state level of 25 mg/L?
Practice exercise (made-up values, not clinical guidance). An 89 kg patient on regular tobramycin doses is at steady state. The target is a peak of 8 mg/L and a trough of 0.5 mg/L, and the volume of distribution is 0.25 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
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