Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 35 mg/L. The half-life is 9 h, and the drug is eliminated by first-order kinetics. What is the level C 27 h later?
Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of vancomycin, which has a half-life of 10 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). A 91 kg patient is to be loaded intravenously with aminophylline to reach a theophylline level of 15 mg/L. The volume of distribution is 0.5 L/kg and the salt factor is S = 0.8. Find the loading dose LD of aminophylline in mg.
Practice exercise (made-up values, not clinical guidance). Vancomycin is given as a continuous infusion to a patient whose vancomycin clearance is 70 mL/min. What infusion rate R in mg/h gives a steady-state level of 25 mg/L?
Practice exercise (made-up values, not clinical guidance). A 95 kg patient takes oral theophylline (F = 1) every 8 h. The clearance is 0.03 L/kg/h. What dose D in mg gives an average steady-state level of 15 mg/L?
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 10 h. How long t does it take to reach 50% of the steady-state level?
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