Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 10 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 8 h later?
Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of gentamicin, which has a half-life of 2 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). A 67 kg patient is to be loaded with digoxin tablets to reach a level of 1 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). A 72 kg patient is to be loaded with digoxin tablets to reach a level of 0.8 mcg/L. The volume of distribution is 7 L/kg and the tablets have a bioavailability F = 0.7. Find the total oral loading dose LD in mcg.
Practice exercise (made-up values, not clinical guidance). A patient's gentamicin half-life is 4 h. The target is a peak of 10 mg/L and a trough of 0.5 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A patient's tobramycin half-life is 3 h. The target is a peak of 6 mg/L and a trough of 1 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
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