Practice exercise (made-up values, not clinical guidance). A patient receives lidocaine as a constant IV infusion without a loading dose. The half-life is 2 h. What percentage f of the steady-state level has been reached after 8 h?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 58 kg needs a loading dose of theophylline to reach a level of 10 mg/L straight away. The volume of distribution is 0.5 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). An 82 kg patient is to be loaded intravenously with aminophylline to reach a theophylline level of 10 mg/L. The volume of distribution is 0.5 L/kg and the salt factor is S = 0.8. Find the loading dose LD of aminophylline in mg.
Practice exercise (made-up values, not clinical guidance). After an IV dose of vancomycin, the level is 25 mg/L at 1 h and 9.9 mg/L at 17 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 75 mg/h with no loading dose. The patient's clearance is 3 L/h and the half-life is 10 h. What is the level C after 27 h?
Practice exercise (made-up values, not clinical guidance). A 66 kg patient takes oral theophylline (F = 1) every 12 h. The clearance is 0.05 L/kg/h. What dose D in mg gives an average steady-state level of 15 mg/L?
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