Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the vancomycin level is 30 mg/L. The half-life is 6 h, and the drug is eliminated by first-order kinetics. What is the level C 11 h later?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 9 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 9 h later?
Practice exercise (made-up values, not clinical guidance). A 70 kg patient receives a theophylline infusion. The clearance is 0.03 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 10 mg/L?
Practice exercise (made-up values, not clinical guidance). After an IV dose of gentamicin, the level is 9 mg/L at 1 h and 2.3 mg/L at 7 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion is started without a loading dose. The half-life in this patient is 9 h. How long t does it take to reach 90% of the steady-state level?
Practice exercise (made-up values, not clinical guidance). A 95 kg patient has a theophylline level of 3.6 mg/L; the target is 12 mg/L. The drug is given intravenously as aminophylline (S = 0.8), and the volume of distribution is 0.5 L/kg. What extra loading dose LD raises the level to the target?
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