Practice exercise (made-up values, not clinical guidance). A patient who weighs 73 kg needs a loading dose of gentamicin to reach a level of 10 mg/L straight away. The volume of distribution is 0.25 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives lidocaine as a constant IV infusion without a loading dose. The half-life is 2 h. What percentage f of the steady-state level has been reached after 6 h?
Practice exercise (made-up values, not clinical guidance). A patient has a lidocaine clearance of 700 mL/min. What infusion rate R in mg/min keeps the steady-state level at 2 mg/L?
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 10 mg/L at 1 h and 1.6 mg/L at 9 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion is started without a loading dose. The half-life in this patient is 8 h. How long t does it take to reach 90% of the steady-state level?
Practice exercise (made-up values, not clinical guidance). A 96 kg patient takes oral aminophylline (S = 0.8, F = 1) every 12 h. The theophylline clearance is 0.03 L/kg/h. What dose D in mg gives an average steady-state level of 15 mg/L?
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