Practice exercise (made-up values, not clinical guidance). A patient who weighs 89 kg needs a loading dose of theophylline to reach a level of 10 mg/L straight away. The volume of distribution is 0.5 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives lidocaine as a constant IV infusion without a loading dose. The half-life is 1.5 h. What percentage f of the steady-state level has been reached after 2.25 h?
Practice exercise (made-up values, not clinical guidance). A 56 kg patient is to receive an aminophylline infusion (salt factor S = 0.8: 80% of aminophylline is theophylline). The theophylline clearance is 0.05 L/kg/h. What aminophylline infusion rate R in mg/h gives a steady-state theophylline level of 10 mg/L?
Practice exercise (made-up values, not clinical guidance). After an IV dose of gentamicin, the level is 9 mg/L at 1 h and 1.8 mg/L at 9 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A 90 kg patient takes oral aminophylline (S = 0.8, F = 1) every 12 h. The theophylline clearance is 0.05 L/kg/h. Each dose is 250 mg of aminophylline. Find the average steady-state level Css,avg.
Practice exercise (made-up values, not clinical guidance). A 65 kg patient on regular gentamicin doses is at steady state. The target is a peak of 8 mg/L and a trough of 0.5 mg/L, and the volume of distribution is 0.25 L/kg. Assuming rapid IV doses, what dose D raises the level from the trough to the peak?
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