Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 6 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 6.5 h later?
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin as a constant IV infusion without a loading dose. The half-life is 12 h. What percentage f of the steady-state level has been reached after 12 h?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 170 mg of tobramycin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). After an IV dose of tobramycin, the level is 10 mg/L at 2 h and 2.5 mg/L at 8 h. Assume first-order elimination. Find the elimination rate constant k.
Practice exercise (made-up values, not clinical guidance). A patient's gentamicin half-life is 4 h. The target is a peak of 8 mg/L and a trough of 1 mg/L. Assuming rapid IV doses and first-order elimination, what dosing interval τ lets the level fall from the peak to the trough? Round to one decimal place.
Practice exercise (made-up values, not clinical guidance). A 75 kg patient takes oral aminophylline (S = 0.8, F = 1) every 8 h. The theophylline clearance is 0.04 L/kg/h. What dose D in mg gives an average steady-state level of 10 mg/L?
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