Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 6 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 10 h later?
Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 7 mg/L. The half-life is 3.5 h, and the drug is eliminated by first-order kinetics. What is the level C 2 h later?
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 180 mg of gentamicin. The level back-extrapolated to time zero is 8 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). An 89 kg patient is to be loaded intravenously with aminophylline to reach a theophylline level of 10 mg/L. The volume of distribution is 0.5 L/kg and the salt factor is S = 0.8. Find the loading dose LD of aminophylline in mg.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 80 mg/h with no loading dose. The patient's clearance is 4 L/h and the half-life is 10 h. What is the level C after 25 h?
Practice exercise (made-up values, not clinical guidance). A theophylline infusion is started without a loading dose. The half-life in this patient is 8 h. How long t does it take to reach 90% of the steady-state level?
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