Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the gentamicin level is 7 mg/L. The half-life is 2.5 h, and the drug is eliminated by first-order kinetics. What is the level C 2 h later?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 82 kg needs a loading dose of tobramycin to reach a level of 6 mg/L straight away. The volume of distribution is 0.3 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A 51 kg patient is to be loaded intravenously with phenytoin sodium to reach a phenytoin level of 15 mg/L. The volume of distribution is 0.7 L/kg and the salt factor is S = 0.92. Find the loading dose LD of phenytoin sodium in mg.
Practice exercise (made-up values, not clinical guidance). A 79 kg patient is to be loaded intravenously with aminophylline to reach a theophylline level of 12 mg/L. The volume of distribution is 0.5 L/kg and the salt factor is S = 0.8. Find the loading dose LD of aminophylline in mg.
Practice exercise (made-up values, not clinical guidance). A 51-year-old woman weighs 57 kg and has a serum creatinine of 2.4 mg/dL (212 µmol/L). Estimate the creatinine clearance with Cockcroft–Gault: CrCl (mL/min) = (140 − age) × weight (kg)/(72 × SCr in mg/dL), × 0.85 for women. The usual atenolol dose is 100 mg for a creatinine clearance of 120 mL/min, and a fraction fe = 0.9 of the drug is excreted unchanged by the kidneys. Using the Dettli dose fraction Q = 1 − fe·(1 − CrCl/normal CrCl), find the adjusted dose D. Round to the nearest whole number.
Practice exercise (made-up values, not clinical guidance). A vancomycin infusion runs at 60 mg/h with no loading dose. The patient's clearance is 3 L/h and the half-life is 8 h. What is the level C after 12 h?
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