Practice exercise (made-up values, not clinical guidance). Just after an IV dose, the tobramycin level is 8 mg/L. The half-life is 3 h, and the drug is eliminated by first-order kinetics. What is the level C 6 h later?
Practice exercise (made-up values, not clinical guidance). A patient starts regular doses of theophylline, which has a half-life of 8 h. Using the rule that steady state is reached after about five half-lives, after how many hours tss is steady state reached?
Practice exercise (made-up values, not clinical guidance). An 89 kg patient receives a theophylline infusion. The clearance is 0.03 L/kg/h. What infusion rate R in mg/h gives a steady-state level of 15 mg/L?
Practice exercise (made-up values, not clinical guidance). After an IV dose of gentamicin, the level is 10 mg/L at 1 h and 3.5 mg/L at 4 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin IV every 12 h; the vancomycin clearance is 5 L/h. Each dose is 1250 mg of vancomycin. Find the average steady-state level Css,avg.
Practice exercise (made-up values, not clinical guidance). A patient receives vancomycin IV every 12 h; the vancomycin clearance is 6 L/h. Each dose is 1500 mg of vancomycin. Find the average steady-state level Css,avg.
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