Practice exercise (made-up values, not clinical guidance). A patient receives lidocaine as a constant IV infusion without a loading dose. The half-life is 2 h. What percentage f of the steady-state level has been reached after 2 h?
Practice exercise (made-up values, not clinical guidance). A patient who weighs 63 kg needs a loading dose of theophylline to reach a level of 10 mg/L straight away. The volume of distribution is 0.5 L/kg. Find the loading dose LD in mg.
Practice exercise (made-up values, not clinical guidance). A patient receives an IV bolus of 200 mg of gentamicin. The level back-extrapolated to time zero is 10 mg/L and the half-life is 2.5 h. Find the clearance CL in L/h.
Practice exercise (made-up values, not clinical guidance). After an IV dose of gentamicin, the level is 9 mg/L at 1 h and 3.3 mg/L at 6 h. Assume first-order elimination. Find the half-life t½.
Practice exercise (made-up values, not clinical guidance). A theophylline infusion runs at 42 mg/h with no loading dose. The patient's clearance is 3.5 L/h and the half-life is 8 h. What is the level C after 23 h?
Practice exercise (made-up values, not clinical guidance). A 50 kg patient has a theophylline level of 3.6 mg/L; the target is 12 mg/L. The drug is given intravenously as aminophylline (S = 0.8), and the volume of distribution is 0.5 L/kg. What extra loading dose LD raises the level to the target?
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